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Equine arterivirus serine peptidase

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Equine arterivirus serine peptidase
Identifiers
EC no.3.4.21.114
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Equine arterivirus serine peptidase (EC 3.4.21.114) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of (Glu/Gln)-(Gly/Ser/Ala) in arterivirus replicase translation products ORF1a and ORF1ab

In the equine arterivirus (EAV), the replicase gene is translated into open reading frame 1a (ORF1a) and ORF1ab [polyprotein]s.

References

  1. ^ Snijder EJ, Wassenaar AL, van Dinten LC, Spaan WJ, Gorbalenya AE (March 1996). "The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases". The Journal of Biological Chemistry. 271 (9): 4864–71. doi:10.1074/jbc.271.9.4864. PMID 8617757.
  2. ^ van Dinten LC, Rensen S, Gorbalenya AE, Snijder EJ (March 1999). "Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and Is essential for virus replication". Journal of Virology. 73 (3): 2027–37. PMC 104445. PMID 9971783.
  3. ^ Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, James MN (October 2002). "Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole". The Journal of Biological Chemistry. 277 (42): 39960–6. doi:10.1074/jbc.m206978200. PMID 12163505.