Acrosin

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acrosin
Acrosin-1FIW.png
Identifiers
EC number 3.4.21.10
CAS number 9068-57-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
Acrosin
Identifiers
Symbol ACR
External IDs OMIM102480 MGI87884 HomoloGene855 ChEMBL: 2738 GeneCards: ACR Gene
EC number 3.4.21.10
Orthologs
Species Human Mouse
Entrez 49 11434
Ensembl ENSG00000100312 ENSMUSG00000022622
UniProt P10323 P23578
RefSeq (mRNA) NM_001097 NM_001205049
RefSeq (protein) NP_001088 NP_001191978
Location (UCSC) Chr 22:
51.18 – 51.18 Mb
Chr 15:
89.57 – 89.57 Mb
PubMed search [1] [2]

Acrosin is a digestive enzyme that acts as a protease. In humans, acrosin is encoded by the ACR gene.[1][2] Acrosin is released from the acrosome of spermatozoa as a consequence of the acrosome reaction. It aids in the penetration of the Zona Pellucida.

Function[edit]

Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.[3]

References[edit]

  1. ^ Adham IM, Klemm U, Maier WM, Engel W (January 1990). "Molecular cloning of human preproacrosin cDNA". Hum. Genet. 84 (2): 125–8. PMID 2298447. 
  2. ^ Honda A, Siruntawineti J, Baba T (2002). "Role of acrosomal matrix proteases in sperm-zona pellucida interactions". Hum. Reprod. Update 8 (5): 405–12. doi:10.1093/humupd/8.5.405. PMID 12398221. 
  3. ^ "Entrez Gene: acrosin". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.