Lotilaner

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Lotilaner
Clinical data
Trade namesCredelio
Legal status
Legal status
  • EU: Rx-only
Identifiers
  • 3-Methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H14Cl3F6N3O3S
Molar mass596.75 g·mol−1
3D model (JSmol)
  • CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F

Lotilaner (INN; trade name Credelio) is a veterinary drug used to control fleas and ticks in dogs.[1] It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and for the treatment and control of tick infestations including lone star tick (Amblyomma americanum), American dog tick (Dermacentor variabilis), black-legged tick (Ixodes scapularis), and brown dog tick (Rhipicephalus sanguineus).[2]

References

  1. ^ Kuntz, Emmanuelle A.; Kammanadiminti, Srinivas (2017). "Safety evaluation of lotilaner in dogs after oral administration as flavoured chewable tablets (Credelio™)". Parasites & Vectors. 10. doi:10.1186/s13071-017-2468-y.
  2. ^ "FREEDOM OF INFORMATION SUMMARY, SUPPLEMENTAL NEW ANIMAL DRUG APPLICATION, NADA 141-494, Credelio, Lotilaner, Chewable Tablets, Dogs". September 3, 2019.
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