Alternative-complement-pathway C3/C5 convertase
| Alternative-complement-pathway C3/C5 convertase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.47 | ||||||||
| CAS no. | 80295-67-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Alternative-complement-pathway C3/C5 convertase (EC 3.4.21.47, complement component C3/C5 convertase (alternative), proenzyme factor B, properdin factor B, C3 proactivator, glycine-rich beta-glycoprotein, heat-labile factor, C3 convertase, C3b,Bb,CVF,Bb,C5 convertase, (C3b)n,Bb, complement C 3(C 5) convertase (amplification), alternative complement pathway C3(C5) convertase, C5 convertase, CVF,Bb, (CVF)-dependent glycine-rich-beta-glucoprotein, cobra venom factor-dependent C3 convertase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg- bond in complement component C5 alpha-chain to yield C5a and C5b
This enzyme is a bimolecular complex of complement fragment Bb with either C3b or cobra venom factor.
See also
References
- ^ Kerr, M.A. (1981). "Human factor B". Methods Enzymol. 80: 102–112. doi:10.1016/s0076-6879(81)80010-9. PMID 7043188.
- ^ Morley, B.J.; Campbell, R.D. (1984). "Internal homologies of the Ba fragment from human complement component Factor B, as a class III MHC antigen". EMBO J. 3 (1): 153–157. PMC 557312. PMID 6323161.
- ^ Müller-Eberhard, H.J. (1988). "Molecular organization and function of the complement system". Annu. Rev. Biochem. 57: 321–347. doi:10.1146/annurev.bi.57.070188.001541. PMID 3052276.
External links
- Alternative-complement-pathway+C3/C5+convertase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)