C5a peptidase
| C5a peptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.110 | ||||||||
| CAS no. | 100179-39-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
C5a peptidase (EC 3.4.21.110, streptococcal C5a peptidase, ScpA, ScpB, SCPA) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- The primary cleavage site is at His67-Lys68 in human C5a with a minor secondary cleavage site at Ala58-Ser59
This enzyme is a surface-associated subtilisin-like serine peptidase with very specific substrate preference.
References
- ^ Wexler, D.E.; Chenoweth, D.E.; Cleary, P.P. (1985). "Mechanism of action of the group A streptococcal C5a inactivator". Proc. Natl. Acad. Sci. USA. 82: 8144–8148. doi:10.1073/pnas.82.23.8144. PMC 391459. PMID 3906656.
- ^ Bohnsack, J.F.; Mollison, K.W.; Buko, A.M.; Ashworth, J.C.; Hill, H.R. (1991). "Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus". Biochem. J. 273: 635–640. PMC 1149811. PMID 1996961.
- ^ Cleary, P.P.; Prahbu, U.; Dale, J.B.; Wexler, D.E.; Handley, J. (1992). "Streptococcal C5a peptidase is a highly specific endopeptidase". Infect. Immun. 60 (12): 5219–5223. PMC 258300. PMID 1452354.
- ^ Anderson, E.T.; Wetherell, M.G.; Winter, L.A.; Olmsted, S.B.; Cleary, P.P.; Matsuka, Y.V. (2002). "Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes". Eur. J. Biochem. 269 (19): 4839–4851. doi:10.1046/j.1432-1033.2002.03183.x. PMID 12354115.
- ^ Stafslien, D.K.; Cleary, P.P. (2000). "Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent protein fusion protein substrate". J. Bacteriol. 182 (11): 3254–3258. doi:10.1128/jb.182.11.3254-3258.2000. PMC 94514. PMID 10809707.
- ^ Terao, Y.; Yamaguchi, M.; Hamada, S.; Kawabata, S. (2006). "Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils". J. Biol. Chem. 281 (20): 14215–14223. doi:10.1074/jbc.M513408200. PMID 16565520.
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External links
- C5a+peptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)