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Cadmium

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Cadmium,  48Cd
Cadmium-crystal bar.jpg
General properties
Pronunciation /ˈkædmiəm/
KAD-mee-əm
Appearance silvery bluish-gray metallic
Cadmium in the periodic table
Hydrogen (diatomic nonmetal)
Helium (noble gas)
Lithium (alkali metal)
Beryllium (alkaline earth metal)
Boron (metalloid)
Carbon (polyatomic nonmetal)
Nitrogen (diatomic nonmetal)
Oxygen (diatomic nonmetal)
Fluorine (diatomic nonmetal)
Neon (noble gas)
Sodium (alkali metal)
Magnesium (alkaline earth metal)
Aluminium (post-transition metal)
Silicon (metalloid)
Phosphorus (polyatomic nonmetal)
Sulfur (polyatomic nonmetal)
Chlorine (diatomic nonmetal)
Argon (noble gas)
Potassium (alkali metal)
Calcium (alkaline earth metal)
Scandium (transition metal)
Titanium (transition metal)
Vanadium (transition metal)
Chromium (transition metal)
Manganese (transition metal)
Iron (transition metal)
Cobalt (transition metal)
Nickel (transition metal)
Copper (transition metal)
Zinc (transition metal)
Gallium (post-transition metal)
Germanium (metalloid)
Arsenic (metalloid)
Selenium (polyatomic nonmetal)
Bromine (diatomic nonmetal)
Krypton (noble gas)
Rubidium (alkali metal)
Strontium (alkaline earth metal)
Yttrium (transition metal)
Zirconium (transition metal)
Niobium (transition metal)
Molybdenum (transition metal)
Technetium (transition metal)
Ruthenium (transition metal)
Rhodium (transition metal)
Palladium (transition metal)
Silver (transition metal)
Cadmium (transition metal)
Indium (post-transition metal)
Tin (post-transition metal)
Antimony (metalloid)
Tellurium (metalloid)
Iodine (diatomic nonmetal)
Xenon (noble gas)
Caesium (alkali metal)
Barium (alkaline earth metal)
Lanthanum (lanthanide)
Cerium (lanthanide)
Praseodymium (lanthanide)
Neodymium (lanthanide)
Promethium (lanthanide)
Samarium (lanthanide)
Europium (lanthanide)
Gadolinium (lanthanide)
Terbium (lanthanide)
Dysprosium (lanthanide)
Holmium (lanthanide)
Erbium (lanthanide)
Thulium (lanthanide)
Ytterbium (lanthanide)
Lutetium (lanthanide)
Hafnium (transition metal)
Tantalum (transition metal)
Tungsten (transition metal)
Rhenium (transition metal)
Osmium (transition metal)
Iridium (transition metal)
Platinum (transition metal)
Gold (transition metal)
Mercury (transition metal)
Thallium (post-transition metal)
Lead (post-transition metal)
Bismuth (post-transition metal)
Polonium (post-transition metal)
Astatine (metalloid)
Radon (noble gas)
Francium (alkali metal)
Radium (alkaline earth metal)
Actinium (actinide)
Thorium (actinide)
Protactinium (actinide)
Uranium (actinide)
Neptunium (actinide)
Plutonium (actinide)
Americium (actinide)
Curium (actinide)
Berkelium (actinide)
Californium (actinide)
Einsteinium (actinide)
Fermium (actinide)
Mendelevium (actinide)
Nobelium (actinide)
Lawrencium (actinide)
Rutherfordium (transition metal)
Dubnium (transition metal)
Seaborgium (transition metal)
Bohrium (transition metal)
Hassium (transition metal)
Meitnerium (unknown chemical properties)
Darmstadtium (unknown chemical properties)
Roentgenium (unknown chemical properties)
Copernicium (transition metal)
Nihonium (unknown chemical properties)
Flerovium (unknown chemical properties)
Moscovium (unknown chemical properties)
Livermorium (unknown chemical properties)
Tennessine (unknown chemical properties)
Oganesson (unknown chemical properties)
Zn

Cd

Hg
silvercadmiumindium
Atomic number (Z) 48
Group, period group 12, period 5
Block d-block
Element category   transition metal, alternatively considered a post-transition metal
Standard atomic weight (Ar) 112.414(4)[1]
Electron configuration [Kr] 4d10 5s2
Electrons per shell
2, 8, 18, 18, 2
Physical properties
Phase solid
Melting point 594.22 K ​(321.07 °C, ​609.93 °F)
Boiling point 1040 K ​(767 °C, ​1413 °F)
Density near r.t. 8.65 g/cm3
when liquid, at m.p. 7.996 g/cm3
Heat of fusion 6.21 kJ/mol
Heat of vaporization 99.87 kJ/mol
Molar heat capacity 26.020 J/(mol·K)
Vapor pressure
P (Pa) 1 10 100 1 k 10 k 100 k
at T (K) 530 583 654 745 867 1040
Atomic properties
Oxidation states 2, 1, −2 ​(a mildly basic oxide)
Electronegativity Pauling scale: 1.69
Ionization energies 1st: 867.8 kJ/mol
2nd: 1631.4 kJ/mol
3rd: 3616 kJ/mol
Atomic radius empirical: 151 pm
Covalent radius 144±9 pm
Van der Waals radius 158 pm
Miscellanea
Crystal structure hexagonal close-packed (hcp)
Hexagonal close packed crystal structure for cadmium
Speed of sound thin rod 2310 m/s (at 20 °C)
Thermal expansion 30.8 µm/(m·K) (at 25 °C)
Thermal conductivity 96.6 W/(m·K)
Electrical resistivity 72.7 nΩ·m (at 22 °C)
Magnetic ordering diamagnetic[2]
Magnetic susceptibility (χmol) −19.8·10−6 cm3/mol[3]
Young's modulus 50 GPa
Shear modulus 19 GPa
Bulk modulus 42 GPa
Poisson ratio 0.30
Mohs hardness 2.0
Brinell hardness 203–220 MPa
CAS Number 7440-43-9
History
Discovery and first isolation Karl Samuel Leberecht Hermann and Friedrich Stromeyer (1817)
Named by Friedrich Stromeyer (1817)
Main isotopes of cadmium
Iso­tope Abun­dance Half-life Decay mode Pro­duct
106Cd 1.25% is stable with 58 neutrons
107Cd syn 6.5 h ε 107Ag
108Cd 0.89% is stable with 60 neutrons
109Cd syn 462.6 d ε 109Ag
110Cd 12.47% is stable with 62 neutrons
111Cd 12.80% is stable with 63 neutrons
112Cd 24.11% is stable with 64 neutrons
113Cd 12.23% 7.7×1015 y β 113In
113mCd syn 14.1 y β 113In
IT 113Cd
114Cd 28.75% is stable with 66 neutrons
115Cd syn 53.46 h β 115In
116Cd 7.51% 3.1×1019 y ββ 116Sn
| references | in Wikidata

Cadmium is a chemical element with symbol Cd and atomic number 48. This soft, bluish-white metal is chemically similar to the two other stable metals in group 12, zinc and mercury. Like zinc, it demonstrates oxidation state +2 in most of its compounds, and like mercury, it has a lower melting point than other transition metals. Cadmium and its congeners are not always considered transition metals, in that they do not have partly filled d or f electron shells in the elemental or common oxidation states. The average concentration of cadmium in Earth's crust is between 0.1 and 0.5 parts per million (ppm). It was discovered in 1817 simultaneously by Stromeyer and Hermann, both in Germany, as an impurity in zinc carbonate.

Cadmium occurs as a minor component in most zinc ores and is a byproduct of zinc production. Cadmium was used for a long time as a corrosion-resistant plating on steel, and cadmium compounds are used as red, orange and yellow pigments, to colour glass, and to stabilize plastic. Cadmium use is generally decreasing because it is toxic (it is specifically listed in the European Restriction of Hazardous Substances[4]) and nickel-cadmium batteries have been replaced with nickel-metal hydride and lithium-ion batteries. One of its few new uses is cadmium telluride solar panels.

Although cadmium has no known biological function in higher organisms, a cadmium-dependent carbonic anhydrase has been found in marine diatoms.

Characteristics[edit]

Physical properties[edit]

Cadmium is a soft, malleable, ductile, bluish-white divalent metal. It is similar in many respects to zinc but forms complex compounds.[5] Unlike most other metals, cadmium is resistant to corrosion and is used as a protective plate on other metals. As a bulk metal, cadmium is insoluble in water and is not flammable; however, in its powdered form it may burn and release toxic fumes.[6]

Chemical properties[edit]

Although cadmium usually has an oxidation state of +2, it also exists in the +1 state. Cadmium and its congeners are not always considered transition metals, in that they do not have partly filled d or f electron shells in the elemental or common oxidation states.[7] Cadmium burns in air to form brown amorphous cadmium oxide (CdO); the crystalline form of this compound is a dark red which changes color when heated, similar to zinc oxide. Hydrochloric acid, sulfuric acid, and nitric acid dissolve cadmium by forming cadmium chloride (CdCl2), cadmium sulfate (CdSO4), or cadmium nitrate (Cd(NO3)2). The oxidation state +1 can be produced by dissolving cadmium in a mixture of cadmium chloride and aluminium chloride, forming the Cd22+ cation, which is similar to the Hg22+ cation in mercury(I) chloride.[5]

Cd + CdCl2 + 2 AlCl3 → Cd2(AlCl4)2

The structures of many cadmium complexes with nucleobases, amino acids, and vitamins have been determined.[8]

Isotopes[edit]

The cadmium-113 total cross section clearly showing the cadmium cut-off

Naturally occurring cadmium is composed of 8 isotopes. Two of them are radioactive, and three are expected to decay but have not done so under laboratory conditions. The two natural radioactive isotopes are 113Cd (beta decay, half-life is 7.7 × 1015 years) and 116Cd (two-neutrino double beta decay, half-life is 2.9 × 1019 years). The other three are 106Cd, 108Cd (both double electron capture), and 114Cd (double beta decay); only lower limits on these half-lives have been determined. At least three isotopes – 110Cd, 111Cd, and 112Cd – are stable. Among the isotopes that do not occur naturally, the most long-lived are 109Cd with a half-life of 462.6 days, and 115Cd with a half-life of 53.46 hours. All of the remaining radioactive isotopes have half-lives of less than 2.5 hours, and the majority have half-lives of less than 5 minutes. Cadmium has 8 known meta states, with the most stable being 113mCd (t1/2 = 14.1 years), 115mCd (t1/2 = 44.6 days), and 117mCd (t1/2 = 3.36 hours).[9]

The known isotopes of cadmium range in atomic mass from 94.950 u (95Cd) to 131.946 u (132Cd). For isotopes lighter than 112 u, the primary decay mode is electron capture and the dominant decay product is element 47 (silver). Heavier isotopes decay mostly through beta emission producing element 49 (indium).[9]

One isotope of cadmium, 113Cd, absorbs neutrons with high selectivity: With very high probability, neutrons with energy below the cadmium cut-off will be absorbed; those higher than the cut-off will be transmitted. The cadmium cut-off is about 0.5 eV, and neutrons below that level are deemed slow neutrons, distinct from intermediate and fast neutrons.[10]

Cadmium is created via the long s-process in low-medium mass stars with masses of 0.6 to 10 solar masses, taking thousands of years.[clarification needed] In that process, a silver atom captures a neutron and then undergoes beta decay.[11]

History[edit]

Cadmium (Latin cadmia, Greek καδμεία meaning "calamine", a cadmium-bearing mixture of minerals that was named after the Greek mythological character Κάδμος, Cadmus, the founder of Thebes) was discovered simultaneously in 1817 by Friedrich Stromeyer[12] and Karl Samuel Leberecht Hermann, both in Germany, as an impurity in zinc carbonate.[4] Stromeyer found the new element as an impurity in zinc carbonate (calamine), and, for 100 years, Germany remained the only important producer of the metal. The metal was named after the Latin word for calamine, because it was found in this zinc ore. Stromeyer noted that some impure samples of calamine changed color when heated but pure calamine did not. He was persistent in studying these results and eventually isolated cadmium metal by roasting and reducing the sulfide. The potential for cadmium yellow as pigment was recognized in the 1840s, but the lack of cadmium limited this application.[13][14][15]

Even though cadmium and its compounds are toxic in certain forms and concentrations, the British Pharmaceutical Codex from 1907 states that cadmium iodide was used as a medication to treat "enlarged joints, scrofulous glands, and chilblains".[16]

In 1907, the International Astronomical Union defined the international ångström in terms of a red cadmium spectral line (1 wavelength = 6438.46963 Å).[17][18] This was adopted by the 7th General Conference on Weights and Measures in 1927. In 1960, the definitions of both the metre and ångström were changed to use krypton.[19]

After the industrial scale production of cadmium started in the 1930s and 1940s, the major application of cadmium was the coating of iron and steel to prevent corrosion; in 1944, 62% and in 1956, 59% of the cadmium in the United States was used for plating.[4][20] In 1956, 24% of the cadmium in the United States was used for a second application in red, orange and yellow pigments from sulfides and selenides of cadmium.[20]

The stabilizing effect of cadmium chemicals like the carboxylates cadmium laurate and cadmium stearate on PVC led to an increased use of those compounds in the 1970s and 1980s. The demand for cadmium in pigments, coatings, stabilizers, and alloys declined as a result of environmental and health regulations in the 1980s and 1990s; in 2006, only 7% of to total cadmium consumption was used for plating, and only 10% was used for pigments.[4] At the same time, these decreases in consumption were compensated by a growing demand for cadmium for nickel-cadmium batteries, which accounted for 81% of the cadmium consumption in the United States in 2006.[21]

Occurrence[edit]

Cadmium metal

Cadmium makes up about 0.1 mg kg−1 (ppm) of Earth's crust.[clarification needed] Compared with the more abundant 65 ppm zinc, cadmium is rare.[22] No significant deposits of cadmium-containing ores are known. Greenockite (CdS), the only cadmium mineral of importance, is nearly always associated with sphalerite (ZnS). This association is caused by geochemical similarity between zinc and cadmium, with no geological process likely to separate them. Thus, cadmium is produced mainly as a byproduct from mining, smelting, and refining sulfidic ores of zinc, and, to a lesser degree, lead and copper. Small amounts of cadmium, about 10% of consumption, are produced from secondary sources, mainly from dust generated by recycling iron and steel scrap. Production in the United States began in 1907,[15] but not until after World War I did cadmium come into wide use.[23][24]

Metallic cadmium can be found in the Vilyuy River basin in Siberia.[25]

Rocks mined for phosphate fertilizers contain varying amounts of cadmium, resulting in a cadmium concentration of as much as 300 mg/kg in the fertilizers and a high cadmium content in agricultural soils.[26][27] Coal can contain significant amounts of cadmium, which ends up mostly in flue dust.[28] Cadmium in soil can be absorbed by crops grown on the land such as in rice. Chinese ministry of agriculture officials have measured in 2002 that 28% of rice it sampled had excess of lead and 10% had an excess of cadmium above limited defined by law. Some plants such as willow trees and poplars have been found to clean both lead and cadmium from soil.[29]

Production[edit]

The British Geological Survey reports that in 2001, China was the top producer of cadmium with almost one-sixth of the world's production, closely followed by South Korea and Japan.[30]

Cadmium is a common impurity in zinc ores, and it is most often isolated during the production of zinc. Some zinc ores concentrates from sulfidic zinc ores contain up to 1.4% of cadmium.[31] In the 1970s, the output of cadmium was 6.5 pounds per ton of zinc.[31] Zinc sulfide ores are roasted in the presence of oxygen, converting the zinc sulfide to the oxide. Zinc metal is produced either by smelting the oxide with carbon or by electrolysis in sulfuric acid. Cadmium is isolated from the zinc metal by vacuum distillation if the zinc is smelted, or cadmium sulfate is precipitated from the electrolysis solution.[24][32]

Applications[edit]

Cadmium is a common component of electric batteries, pigments,[33] coatings,[34] and electroplating.[35]

Batteries[edit]

Ni-Cd batteries

In 2009, 86% of cadmium was used in batteries, predominantly in rechargeable nickel-cadmium batteries. Nickel-cadmium cells have a nominal cell potential of 1.2 V. The cell consists of a positive nickel hydroxide electrode and a negative cadmium electrode plate separated by an alkaline electrolyte (potassium hydroxide).[36] The European Union put a limit on cadmium in electronics in 2004 of 0.01%,[37] with some exceptions, and reduced the limit on cadmium content to 0.002%.[38]

Electroplating[edit]

A photograph and representative spectrum of photoluminescence from colloidal CdSe quantum dots

Cadmium electroplating, consuming 6% of the global production, is used in the aircraft industry to reduce corrosion of steel components.[35] This coating is passivated by chromate salts.[34] A limitation of cadmium plating is hydrogen embrittlement of high-strength steels from the electroplating process. Therefore, steel parts heat-treated to tensile strength above 1300 MPa (200 ksi) should be coated by an alternative method (such as special low-embrittlement cadmium electroplating processes or physical vapor deposition).

Titanium embrittlement from cadmium-plated tool residues resulted in banishment of those tools (and the implementation of routine tool testing to detect cadmium contamination) in the A-12/SR-71, U-2, and subsequent aircraft programs that use titanium.[39]

Nuclear fission[edit]

Cadmium is used in the control rods of nuclear reactors, acting as a very effective "neutron poison" to control neutron flux in nuclear fission.[35] When cadmium rods are inserted in the core of a nuclear reactor, cadmium absorbs neutrons preventing them from creating additional fission events, thus controlling the amount of reactivity. The pressurized water reactor designed by Westinghouse Electric Company uses an alloy consisting of 80% silver, 15% indium, and 5% cadmium.[35]

Compounds[edit]

Train painted with cadmium orange

Cadmium oxide was used in black and white television phosphors and in the blue and green phosphors of color television cathode ray tubes.[40] Cadmium sulfide (CdS) is used as a photoconductive surface coating for photocopier drums.[41]

Cadmium sulfide

Various cadmium salts are used in paint pigments, with CdS as a yellow pigment being the most common. Cadmium selenide is a red pigment, commonly called cadmium red. To painters who work with the pigment, cadmium provides the most brilliant and durable yellows, oranges, and reds — so much so that during production, these colors are significantly toned down before they are ground with oils and binders or blended into watercolors, gouaches, acrylics, and other paint and pigment formulations. Because these pigments are potentially toxic, users should use a barrier cream on the hands to prevent absorption through the skin[33] even though the amount of cadmium absorbed into the body through the skin is reported to be less than 1%.[6]

In PVC, cadmium was used as heat, light, and weathering stabilizers.[35][42] Currently, cadmium stabilizers have been completely replaced with barium-zinc, calcium-zinc and organo-tin stabilizers. Cadmium is used in many kinds of solder and bearing alloys, because a low coefficient of friction and fatigue resistance.[35] It is also found in some of the lowest-melting alloys, such as Wood's metal.[43]

Laboratory uses[edit]

Violet light from a helium cadmium metal vapor laser. The highly monochromatic color arises from the 441.563 nm transition line of cadmium.

Helium–cadmium lasers are a common source of blue-ultraviolet laser light. They operate at either 325 or 422 nm in fluorescence microscopes and various laboratory experiments.[44][45] Cadmium selenide quantum dots emit bright luminescence under UV excitation (He-Cd laser, for example). The color of this luminescence can be green, yellow or red depending on the particle size. Colloidal solutions of those particles are used for imaging of biological tissues and solutions with a fluorescence microscope.[46]

Cadmium is a component of some compound semiconductors, such as cadmium sulfide, cadmium selenide, and cadmium telluride, used for light detection and solar cells. HgCdTe is sensitive to infrared[35] light and can be used as an infrared detector, motion detector, or switch in remote control devices.

In molecular biology, cadmium is used to block voltage-dependent calcium channels from fluxing calcium ions, as well as in hypoxia research to stimulate proteasome-dependent degradation of Hif-1α.[47]

Cadmium-selective sensors[edit]

Cadmium-selective sensors based on the fluorophore BODIPY have been developed for imaging and sensing of cadmium in cells.[48]

Biological role[edit]

Cadmium has no known function in higher organisms,[49] but a cadmium-dependent carbonic anhydrase has been found in some marine diatoms.[50] The diatoms live in environments with very low zinc concentrations and cadmium performs the function normally carried out by zinc in other anhydrases. This was discovered with X-ray absorption fluorescence spectroscopy (XAFS).[50][51]

The highest concentration of cadmium is absorbed in the kidneys of humans, and up to about 30 mg of cadmium is commonly inhaled throughout human childhood and adolescence.[52]

Cadmium can be used to block calcium channels in chicken neurons.[53] Analytical methods for the determination of cadmium in biological samples have been reviewed.[54]

Environment[edit]

The biogeochemistry of cadmium and its release to the environment has been the subject of review, as has the speciation of cadmium in the environment.[55][56]

Safety[edit]

The bioinorganic aspects of cadmium toxicity have been reviewed.[57]

The most dangerous form of occupational exposure to cadmium is inhalation of fine dust and fumes, or ingestion of highly soluble cadmium compounds.[4] Inhalation of cadmium fumes can result initially in metal fume fever but may progress to chemical pneumonitis, pulmonary edema, and death.[58]

Cadmium is also an environmental hazard. Human exposure is primarily from fossil fuel combustion, phosphate fertilizers, natural sources, iron and steel production, cement production and related activities, nonferrous metals production, and municipal solid waste incineration.[4] Bread, root crops, and vegetables also contribute to the cadmium in modern populations.[59]

There have been a few instances of general population poisoning as the result of long-term exposure to cadmium in contaminated food and water, and research into an estrogen mimicry that may induce breast cancer is ongoing.[59] In the decades leading up to World War II, mining operations contaminated the Jinzū River in Japan with cadmium and traces of other toxic metals. As a consequence, cadmium accumulated in the rice crops along the riverbanks downstream of the mines. Some members of the local agricultural communities consumed the contaminated rice and developed itai-itai disease and renal abnormalities, including proteinuria and glucosuria.[60]

Jinzū River area, which was contaminated with cadmium

The victims of this poisoning were almost exclusively post-menopausal women with low iron and other mineral body stores. Similar general population cadmium exposures in other parts of the world have not resulted in the same health problems because the populations maintained sufficient iron and other mineral levels. Thus, although cadmium is a major factor in the itai-itai disease in Japan, most researchers have concluded that it was one of several factors.[4] Cadmium is one of six substances banned by the European Union's Restriction on Hazardous Substances (RoHS) directive, which regulates hazardous substances in electrical and electronic equipment but allows for certain exemptions and exclusions from the scope of the law.[61] The International Agency for Research on Cancer has classified cadmium and cadmium compounds as carcinogenic to humans.[62] Although occupational exposure to cadmium is linked to lung and prostate cancer, there is still a substantial controversy about the carcinogenicity of cadmium in low environmental exposure. Recent data from epidemiological studies suggest that intake of cadmium through diet associates to higher risk of endometrial, breast and prostate cancer as well as to osteoporosis in humans.[63][64][65][66] A recent study has demonstrated that endometrial tissue is characterized by higher levels of cadmium in current and former smoking females.[67]

Cadmium exposure is a risk factor associated with a large number of illnesses including kidney disease,[68] early atherosclerosis, hypertension, and cardiovascular diseases.[69] Although studies show a significant correlation between cadmium exposure and occurrence of disease in human populations, a necessary molecular mechanism has not been identified. One hypothesis holds that cadmium is an endocrine disruptor and some experimental studies have shown that it can interact with different hormonal signaling pathways. For example, cadmium can bind to the estrogen receptor alpha,[70][71] and affect signal transduction along the estrogen and MAPK signaling pathways at low doses.[72][73][74]

The tobacco plant readily absorbs and accumulates heavy metals, such as cadmium from the surrounding soil into its leaves. These are readily absorbed into the user's body following smoke inhalation.[75]Tobacco smoking is the most important single source of cadmium exposure in the general population. An estimated 10% of the cadmium content of a cigarette is inhaled through smoking. Absorption of cadmium through the lungs is more effective than through the gut, and as much as 50% of the cadmium inhaled in cigarette smoke may be absorbed.[76] On average, cadmium concentrations in the blood of smokers is 4 times 5 times greater and in the kidney, 2–3 times greater than non-smokers. Despite the high cadmium content in cigarette smoke, there seems to be little exposure to cadmium from passive smoking.[77]

In a non-smoking population, food is the greatest source of exposure. High quantities of cadmium can be found in crustaceans, mollusks, offal, and algae products. However, grains, vegetables, and starchy roots and tubers are consumed in much greater quantity in the US, and are the source of the greatest dietary exposure.[78] Most plants bio-accumulate metal toxins like Cd, and when composted to form organic fertilizers yield a product which can often contain high amounts (e.g., over 0.5 mg) of metal toxins for every kilo of fertilizer. Fertilizers made from animal dung (e.g., cow dung) or urban waste can contain similar amounts of Cd. The Cd added to the soil from fertilizers (rock phosphates or organic fertilizers) become bio-available and toxic only if the soil pH is low (i.e., acidic soils). Zinc is chemically similar to cadmium and some evidence indicates the presence of Zn ions reduces cadmium toxicity.[79]

Zinc, Cu, Ca, and Fe ions, and selenium with vitamin C are used to treat Cd intoxication, though it is not easily reversed.[68]

Regulations[edit]

Because of the adverse effects of cadmium on the environment and human health, the supply and use of cadmium is restricted in Europe under the REACH Regulation.[80]

The EFSA Panel on Contaminants in the Food Chain specifies that 2.5 μg/kg body weight is a tolerable weekly intake for humans.[78] The Joint FAO/WHO Expert Committee on Food Additives has declared 7 μg/kg bw to be the provisional tolerable weekly intake level.[81]

The US Occupational Safety and Health Administration (OSHA) has set the permissible exposure limit (PEL) for cadmium at a time-weighted average (TWA) of 0.005 ppm. The National Institute for Occupational Safety and Health (NIOSH) has not set a recommended exposure limit (REL) and has designated cadmium as a known human carcinogen. The IDLH (immediately dangerous to life and health) level for cadmium is 9 mg/m3.[82]

Lethal dose[83] Organism Route Time
LD50: 225 mg/kg rat oral n/a
LD50: 890 mg/kg mouse oral n/a
LC50: 25 mg/m3 rat n/a 30 min

Product recalls[edit]

In May 2006, a sale of the seats from Arsenal F.C.'s old stadium, Highbury in London, England was cancelled when the seats were discovered to contain trace amounts of cadmium.[84] Reports of high levels of cadmium use in children's jewelry in 2010 led to a US Consumer Product Safety Commission investigation.[85] The U.S. CPSC issued specific recall notices for cadmium content in jewelry sold by Claire's[86] and Wal-Mart[87] stores.

In June 2010, McDonald's voluntarily recalled more than 12 million promotional "Shrek Forever After 3D" Collectable Drinking Glasses because of the cadmium levels in paint pigments on the glassware.[88] The glasses were manufactured by Arc International, of Millville, NJ, USA.[89]

See also[edit]

References[edit]

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  2. ^ Lide, D. R., ed. (2005). "Magnetic susceptibility of the elements and inorganic compounds". CRC Handbook of Chemistry and Physics (PDF) (86th ed.). Boca Raton (FL): CRC Press. ISBN 0-8493-0486-5. 
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Further reading[edit]

  • Hartwig, Andrea (2013). "Chapter 15. Cadmium and cancer". In Astrid Sigel; Helmut Sigel; Roland K. O. Sigel. Cadmium: From Toxicology to Essentiality. Metal Ions in Life Sciences. 11. Springer. pp. 491–507. doi:10.1007/978-94-007-5179-8_15. 

External links[edit]