Charles Sawyers

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Charles L. Sawyers
Charles Sawyers.jpg
Born Charles Lazelle Sawyers[1]
1959 (age 58–59)
Nashville, Tennessee
Education Johns Hopkins University, Princeton, UCSF
Medical career
Profession Physician
Institutions Memorial Sloan Kettering Cancer Center
Howard Hughes Medical Institute
Research Leukemia/Prostate Cancer
Notable prizes Lasker Clinical Award (2009)
BBVA Foundation Frontiers of Knowledge Award (2014)

Charles L. Sawyers is a Howard Hughes Medical Institute (HHMI) investigator who holds the Marie-Josée and Henry R. Kravis Chair of the Human Oncology and Pathogenesis Program (HOPP) at Memorial Sloan Kettering Cancer Center (MSK). HOPP is a program created in 2006 that comprises researchers from many disciplines to bridge clinical and laboratory discoveries.[2]

Career[edit]

Sawyers received a BA from Princeton University in 1981 and an MD from Johns Hopkins University School of Medicine in 1985,[3] followed by an internal medicine residency at the University of California, San Francisco.[4] He became a HHMI investigator in 2002 while at working at UCLA's Jonsson Cancer Center.[5]

Sawyers works on molecularly targeted cancer drugs, with a focus on developing a new generation of treatment options for patients. He shared the 2009 Lasker-DeBakey Clinical Medical Research Award with Brian J. Druker and Nicholas Lydon,[6] for the development of the ABL kinase inhibitor imatinib for patients with chronic myeloid leukemia and the second generation ABL inhibitor dasatinib to overcome imatinib resistance. He also co-discovered the antiandrogen drug enzalutamide that was approved by the FDA in 2012 for treatment of advanced prostate cancer.[7]

Significant positions[edit]

Sawyers served as President of the American Society for Clinical Investigation (ASCI) in 2007[8] and of the American Association for Cancer Research (AACR) in 2012.[9] He was also appointed to the National Cancer Advisory Board by President Obama in 2012,[10] and has served on the Board of Directors of Novartis since 2013.[11]

Memberships[edit]

Awards[edit]

References[edit]

  1. ^ Howard Hughes Medical Institute, Annual Scientific Report, The Institute, 1990, p. 507.
  2. ^ "At Work: Human Oncology and Pathogenesis Program Chair Charles Sawyers | Memorial Sloan Kettering Cancer Center". www.mskcc.org. Retrieved 5 April 2017. 
  3. ^ "Susan Schneck Weds Charles Sawyers". The New York Times. 22 October 1990. Retrieved 3 March 2017. 
  4. ^ "UCSF Department of Medicine Alumni Profile: Dr. Charles Sawyers". medicine.ucsf.edu. Retrieved 3 March 2017. 
  5. ^ "Charles L. Sawyers, MD". HHMI.org. Retrieved 5 April 2017. 
  6. ^ Grindlinger, Brooke; Chao, ES (1 October 2009). "Trio receives Lasker Foundation Clinical Award for breakthroughs in leukemia treatment". Journal of Clinical Investigation. 119 (10): 2863–2865. doi:10.1172/JCI41141. ISSN 0021-9738. PMC 2752112Freely accessible. PMID 2752112. 
  7. ^ Reyes, AA; Akeson, R; Yoo, Dongwon; Sawyers, Charles L.; Chen, Charlie; Tran, Chris; Wongvipat, John (October 1988). "Generation of multiple independent substitution mutants by M13 in vitro mutagenesis using a single mutagenic oligonucleotide". DNA (Mary Ann Liebert, Inc.). 7 (8): 579–84. doi:10.1021/jm901488g. ISSN 0022-2623. PMC 3180999Freely accessible. PMID 3180999. 
  8. ^ "2008 American Society of Clinical Investigation Presidential Address" (PDF). the-asci.org. Retrieved 3 March 2017. 
  9. ^ "Charles L. Sawyers, MD". aacr.org. Retrieved 4 March 2017. 
  10. ^ "President Obama Announces More Key Administration Posts". whitehouse.gov. 6 December 2012. Retrieved 4 March 2017. 
  11. ^ "Charles L. Sawyers, M.D. Member of the Board of Directors" (PDF). novartis.com. Retrieved 4 March 2017. 
  12. ^ "Doris Duke Charitable Foundation Awards $10.5 Million for Medical Research". Philanthropy News Digest (PND). Retrieved 5 April 2017. 
  13. ^ "Recipients of the David A. Karnofsky Memorial Award and Lecture - The ASCO Post". www.ascopost.com. Retrieved 5 April 2017. 
  14. ^ "Awards, Appointments, Announcements". JNCI Journal of the National Cancer Institute. 1 June 2005. pp. 797–797. doi:10.1093/jnci/97.11.797. Retrieved 5 April 2017. 
  15. ^ "Dorothy P. Landon-AACR Prize for Translational Cancer Research". www.aacr.org. Retrieved 5 April 2017. 
  16. ^ Foundation, Lasker. "Molecularly targeted treatments for chronic myeloid leukemia | The Lasker Foundation". The Lasker Foundation. Retrieved 5 April 2017. 
  17. ^ "Breakthrough Prize". breakthroughprize.org. Retrieved 5 April 2017. 
  18. ^ "Taubman Prize". A. Alfred Taubman Medical Research Institute. Retrieved 16 March 2017. 
  19. ^ "2014 Honorees". The Hope Funds for Cancer Research. 5 September 2013. Retrieved 5 April 2017. 
  20. ^ "BBVA Foundation Frontiers of Knowledge Awards". www.fbbva.es. Retrieved 5 April 2017. 

External links[edit]