Charles L. Sawyers
Charles Lazelle Sawyers
1959 (age 60–61)
|Education||Johns Hopkins University, Princeton, UCSF|
|Institutions||Memorial Sloan Kettering Cancer Center|
Howard Hughes Medical Institute
|Awards||Lasker Clinical Award (2009)|
BBVA Foundation Frontiers of Knowledge Award (2014)
Charles L. Sawyers is a Howard Hughes Medical Institute (HHMI) investigator who holds the Marie-Josée and Henry R. Kravis Chair of the Human Oncology and Pathogenesis Program (HOPP) at Memorial Sloan Kettering Cancer Center (MSK). HOPP is a program created in 2006 that comprises researchers from many disciplines to bridge clinical and laboratory discoveries.
Sawyers received a BA from Princeton University in 1981 and an MD from Johns Hopkins University School of Medicine in 1985, followed by an internal medicine residency at the University of California, San Francisco. He became a HHMI investigator in 2002 while at working at UCLA's Jonsson Cancer Center.
Sawyers works on molecularly targeted cancer drugs, with a focus on developing a new generation of treatment options for patients. He shared the 2009 Lasker-DeBakey Clinical Medical Research Award with Brian J. Druker and Nicholas Lydon, for the development of the ABL kinase inhibitor imatinib for patients with chronic myeloid leukemia and the second generation ABL inhibitor dasatinib to overcome imatinib resistance. He also co-discovered the antiandrogen drug enzalutamide that was approved by the FDA in 2012 for treatment of advanced prostate cancer.
Sawyers' cancer research is discussed in the second episode of Cancer: The Emperor of All Maladies.
Sawyers served as President of the American Society for Clinical Investigation (ASCI) in 2007 and of the American Association for Cancer Research (AACR) in 2012. He was also appointed to the National Cancer Advisory Board by President Obama in 2012, and has served on the Board of Directors of Novartis since 2013.
- Doris Duke Distinguished Clinical Scientist Award (2001)
- David A. Karnofsky Memorial Award, American Society of Clinical Oncology (2005)
- Richard and Hinda Rosenthal Foundation Award, American Association for Cancer Research (2005)
- Dorothy P. Landon–AACR Prize for Translational Cancer Research (2009)
- Lasker-DeBakey Clinical Medical Research Award (2009)
- Breakthrough Prize in Life Sciences (2013)
- Taubman Prize for Excellent in Translational Medical Science (2013)
- Hope Funds for Cancer Research Award of Excellence for Clinical Development (2014)
- BBVA Foundation Frontiers of Knowledge Award in Biomedicine along with Tony Hunter and Joseph Schlessinger (2014)
- The Scheele Award (2017), The Swedish Academy of Pharmaceutical Science.
- Howard Hughes Medical Institute, Annual Scientific Report, The Institute, 1990, p. 507.
- "At Work: Human Oncology and Pathogenesis Program Chair Charles Sawyers | Memorial Sloan Kettering Cancer Center". www.mskcc.org. Retrieved 5 April 2017.
- "Susan Schneck Weds Charles Sawyers". The New York Times. 22 October 1990. Retrieved 3 March 2017.
- "UCSF Department of Medicine Alumni Profile: Dr. Charles Sawyers". medicine.ucsf.edu. Retrieved 3 March 2017.
- "Charles L. Sawyers, MD". HHMI.org. Retrieved 5 April 2017.
- Grindlinger, Brooke; Chao, ES (1 October 2009). "Trio receives Lasker Foundation Clinical Award for breakthroughs in leukemia treatment". Journal of Clinical Investigation. 119 (10): 2863–2865. doi:10.1172/JCI41141. ISSN 0021-9738. PMC 2752112.
- Reyes, Antonio A.; Akeson, Richard (1988). "Generation of Multiple Independent Substitution Mutants by M13 in Vitro Mutagenesis Using a Single Mutagenic Oligonucleotide". DNA. 7 (8): 579–584. doi:10.1089/dna.1.1988.7.579. PMID 3180999.
- "2008 American Society of Clinical Investigation Presidential Address" (PDF). the-asci.org. Retrieved 3 March 2017.
- "Charles L. Sawyers, MD". aacr.org. Retrieved 4 March 2017.
- "President Obama Announces More Key Administration Posts". whitehouse.gov. 6 December 2012. Retrieved 4 March 2017.
- "Charles L. Sawyers, M.D. Member of the Board of Directors" (PDF). novartis.com. Retrieved 4 March 2017.
- "Doris Duke Charitable Foundation Awards $10.5 Million for Medical Research". Philanthropy News Digest (PND). Retrieved 5 April 2017.
- "Recipients of the David A. Karnofsky Memorial Award and Lecture - The ASCO Post". www.ascopost.com. Archived from the original on 19 September 2017. Retrieved 5 April 2017.
- "Awards, Appointments, Announcements". JNCI Journal of the National Cancer Institute. 97 (11): 797. 1 June 2005. doi:10.1093/jnci/97.11.797.
- "Dorothy P. Landon-AACR Prize for Translational Cancer Research". www.aacr.org. Retrieved 5 April 2017.
- Foundation, Lasker. "Molecularly targeted treatments for chronic myeloid leukemia | The Lasker Foundation". The Lasker Foundation. Retrieved 5 April 2017.
- "Breakthrough Prize". breakthroughprize.org. Retrieved 5 April 2017.
- "Taubman Prize". A. Alfred Taubman Medical Research Institute. Retrieved 16 March 2017.
- "2014 Honorees". The Hope Funds for Cancer Research. 5 September 2013. Retrieved 5 April 2017.
- "BBVA Foundation Frontiers of Knowledge Awards". www.fbbva.es. Archived from the original on 21 September 2015. Retrieved 5 April 2017.
- Memorial Sloan Kettering Cancer Center - Biography, Lab Description
- Human Oncology and Pathogenesis Program
- Howard Hughes Medical Institute - Biography, Lab Description
- Video:Talk by Sawyers at the NIH-Lasker Clinical Research Scholars Symposium, March 31, 2011.
- Video:Speaking to Katie Couric regarding Stand Up 2 Cancer - @KatieCouric, CBS news, September 8, 2010
- Quoted: New Drugs Stir Debate on Rules of Clinical Trials, New York Times, September 19, 2010
- Quoted: What can we learn from curable cancers? Newsweek, September 7, 2010
- Video: Speaking with Charlie Rose: A discussion about Cancer Treatments, October 1, 2009