Flavivirin
| Flavivirin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.91 | ||||||||
| CAS no. | 154215-26-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Flavivirin (EC 3.4.21.91, Yellow fever virus (flavivirus) protease, NS2B-3 proteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Selective hydrolysis of -Xaa-Xaa-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala
This enzyme is present in classical flaviviruses (yellow fever, dengue fever).
References
- ^ Chambers, T.J.; Hahn, C.S.; Galler, R.; Rice, C.M. (1990). "Flavivirus genome organization, expression, and replication". Annu. Rev. Microbiol. 44: 649–688. doi:10.1146/annurev.mi.44.100190.003245. PMID 2174669.
- ^ Cahour, A.; Falgout, B.; Lai, C.-J. (1992). "Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease". J. Virol. 66: 1535–1542. PMID 1531368.
- ^ Lin, C.; Amberg, S.M.; Chambers, T.J.; Rice, C.M. (1993). "Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site". J. Virol. 67: 2327–2335. PMID 8445732.
External links
- Flavivirin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)