Fosfluconazole

Fosfluconazole
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	IV
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name {[2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-yl]oxy}phosphonic acid;
CAS Number	194798-83-9 ;
PubChem CID	214356;
ChemSpider	185843 ;
UNII	3JIJ299EWH;
ChEMBL	ChEMBL1908301 ;
CompTox Dashboard (EPA)	DTXSID3048601 ;
Chemical and physical data
Formula	C13H13F2N6O4P
Molar mass	386.25 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc1ccc(c(F)c1)C(OP(=O)(O)O)(Cn2ncnc2)Cn3ncnc3;
	InChI InChI=1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24) ; Key:GHJWNRRCRIGGIO-UHFFFAOYSA-N ;
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Fosfluconazole (INN) is a water-soluble phosphate prodrug of fluconazole - a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. The phosphate ester bond is hydrolysed by the action of a phosphatase - an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (see dephosphorylation).

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