Guanosine nucleotide dissociation inhibitor
Appearance
GDP dissociation inhibitor | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||
Symbol | GDI | ||||||||||
Pfam | PF00996 | ||||||||||
InterPro | IPR002005 | ||||||||||
SCOP2 | 1gnd / SCOPe / SUPFAM | ||||||||||
|
A guanosine nucleotide dissociation inhibitor (GDI) binds to the GDP-bound form of Rho and Rab small GTPases and not only prevents exchange (maintaining the small GTPase in an off-state), but also prevents the small GTPase from localizing at the membrane, which is their place of action. This inhibition can be removed by the action of a GDI displacement factor.[1] It also inhibits cdc42 by binding to its tail and preventing its insertion into membranes; hence it cannot trigger WASPs and cannot lead to nucleation of F-actin.
References
- ^ Dirac-Svejstrup, A B. "Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI". The EMBO Journal. Retrieved 31 January 2013.
External links
- Guanine+Nucleotide+Dissociation+Inhibitors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)