KLK1

KLK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SPJ
Identifiers
Aliases	KLK1, KLKR, Klk6, hK1, kallikrein 1
External IDs	OMIM: 147910; MGI: 102850; HomoloGene: 110727; GeneCards: KLK1; OMA:KLK1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,823,787 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,879,042 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; mucosa of transverse colon; ; parotid gland; ; rectum; ; skin of abdomen; ; islet of Langerhans; ; skin of leg; ; beta cell; ; skin of arm; ; gonad;
	Top expressed in
	submandibular gland; ; parotid gland; ; right kidney; ; left colon; ; human kidney; ; pyloric antrum; ; lacrimal gland; ; crypt of lieberkuhn of small intestine; ; duodenum; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity;
Cellular component	extracellular exosome; nucleus; secretory granule;
Biological process	proteolysis; regulation of systemic arterial blood pressure; zymogen activation;
	Sources:Amigo / QuickGO
Orthologs
	3816
	16612
	ENSG00000167748
	ENSMUSG00000063903
	P06870
	P15947
	NM_002257
	NM_010639; NM_001320331; NM_001320332
	NP_002248
	NP_001307260; NP_001307261; NP_034769
	Wikidata
View/Edit Human	View/Edit Mouse

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene.^[5]^[6]^[7] KLK1 is a member of the peptidase S1 family.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167748 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063903 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, Shaw D (Feb 1992). "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker". Genomics. 11 (1): 77–82. doi:10.1016/0888-7543(91)90103-L. PMID 1684954.
^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.
^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

v t e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/S1P4 Sedolisin/TPP1 Streptokinase Cathepsin A G