Megakaryocyte-associated tyrosine kinase

MATK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JWO, 1X6G, 3US4
Identifiers
Aliases	MATK, CHK, CTK, HHYLTK, HYL, HYLTK, Lsk, Megakaryocyte-associated tyrosine kinase
External IDs	OMIM: 600038; MGI: 99259; HomoloGene: 48104; GeneCards: MATK; OMA:MATK - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,802,129 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,099,199 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; Brodmann area 9; ; amygdala; ; prefrontal cortex; ; nucleus accumbens; ; putamen; ; caudate nucleus;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord; ; entorhinal cortex; ; perirhinal cortex; ; hippocampus proper; ; olfactory tubercle; ; subiculum; ; lateral septal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein binding; protein tyrosine kinase activity; signaling receptor binding; ATP binding;
Cellular component	cytoplasm; cytosol; membrane; extrinsic component of cytoplasmic side of plasma membrane;
Biological process	cell differentiation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; protein phosphorylation; positive regulation of cell population proliferation; peptidyl-tyrosine autophosphorylation; mesoderm development; cell population proliferation; innate immune response; ERBB2 signaling pathway; peptidyl-tyrosine phosphorylation; regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	4145
	17179
	ENSG00000007264
	ENSMUSG00000004933
	P42679
	P41242
	NM_002378; NM_139354; NM_139355
	NM_001285853; NM_001285854; NM_001285855; NM_010768
	NP_002369; NP_647611; NP_647612
	NP_001272782; NP_001272783; NP_001272784; NP_034898
	Wikidata
View/Edit Human	View/Edit Mouse

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

Megakaryocyte-associated tyrosine kinase has been shown to interact with CD117^[8]^[9] and TrkA.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007264 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004933 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bennett BD, Cowley S, Jiang S, London R, Deng B, Grabarek J, Groopman JE, Goeddel DV, Avraham H (February 1994). "Identification and characterization of a novel tyrosine kinase from megakaryocytes". J Biol Chem. 269 (2): 1068–74. PMID 8288563.
^ Avraham S, Jiang S, Ota S, Fu Y, Deng B, Dowler LL, White RA, Avraham H (February 1995). "Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product". J Biol Chem. 270 (4): 1833–42. doi:10.1074/jbc.270.4.1833. PMID 7530249.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: MATK megakaryocyte-associated tyrosine kinase".
^ Jhun, B H; Rivnay B; Price D; Avraham H (April 1995). "The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit". J. Biol. Chem. 270 (16). UNITED STATES: 9661–6. doi:10.1074/jbc.270.16.9661. ISSN 0021-9258. PMID 7536744. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Price, D J; Rivnay B; Fu Y; Jiang S; Avraham S; Avraham H (February 1997). "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes". J. Biol. Chem. 272 (9). UNITED STATES: 5915–20. doi:10.1074/jbc.272.9.5915. ISSN 0021-9258. PMID 9038210. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Yamashita, H; Avraham S; Jiang S; Dikic I; Avraham H (May 1999). "The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells". J. Biol. Chem. 274 (21). UNITED STATES: 15059–65. doi:10.1074/jbc.274.21.15059. ISSN 0021-9258. PMID 10329710. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Interactions

References

Further reading