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Mesophyll can refer to:
- Mesophyll tissue, in plant anatomy, photosynthetic parenchyma cells that lie between the upper and lower epidermis layers of a leaf
- In ecology, the blade of a leaf or leaflet that has a surface area 4500–18225 mm2. Compare macrophyll, megaphyll, microphyll, nanophyll, notophyll.
- A plant, or vegetation, that has mesophyll (sized) leave
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