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Myelin-associated glycoprotein

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MAG
Identifiers
AliasesMAG, GMA, S-SIGLEC-4A, SIGLEC4A, SPG75, myelin associated glycoprotein
External IDsOMIM: 159460; MGI: 96912; HomoloGene: 1771; GeneCards: MAG; OMA:MAG - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_080600
NM_001199216
NM_002361

RefSeq (protein)

NP_001186145
NP_002352
NP_542167

Location (UCSC)Chr 19: 35.29 – 35.31 MbChr 7: 30.6 – 30.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
myelin associated glycoprotein
Identifiers
SymbolMAG
Alt. symbolsGMA
NCBI gene4099
HGNC6783
OMIM159460
RefSeqNM_080600
UniProtP20916
Other data
LocusChr. 19 q13.1
Search for
StructuresSwiss-model
DomainsInterPro

Myelin-associated glycoprotein (MAG, Siglec-4) is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR.[5] MAG is believed to be involved in myelination during nerve regeneration.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105695Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036634Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Quarles RH (2007). "Myelin-associated glycoprotein (MAG): past, present and beyond". Journal of Neurochemistry. 100 (6): 1431–48. doi:10.1111/j.1471-4159.2006.04319.x. PMID 17241126.
  6. ^ Barton D, Arquint M, Roder J, Dunn R, Francke U (1987). "The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice". Genomics. 1 (2): 107–12. doi:10.1016/0888-7543(87)90002-4. PMID 2447011.