Pestivirus NS3 polyprotein peptidase
| Pestivirus NS3 polyprotein peptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.113 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pestivirus NS3 polyprotein peptidase (EC 3.4.21.113, border disease virus NS3 endopeptidase, BDV NS3 endopeptidase, bovine viral diarrhea virus NS3 endopeptidase, BVDV NS3 endopeptidase, classical swine fever virus NS3 endopeptidase, CSFV NS3 endopeptidase, p80) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Leu is conserved at position P1 for all four cleavage sites. Alanine is found at position P1' of the NS4A-NS4B cleavage site, whereas serine is found at position P1' of the NS3-NS4A, NS4B-NS5A and NS5A-NS5B cleavage sites
The genomes of Cytopathogenic pestivirus strains express at least one additional protein, called NS3 (p80).
References
- ^ Wiskerchen, M.; Collett, M.S. (1991). "Pestivirus gene expression: protein p80 of bovine viral diarrhea virus is a proteinase involved in polyprotein processing". Virology. 184: 341–350. doi:10.1016/0042-6822(91)90850-b. PMID 1651596.
- ^ Tautz, N.; Elbers, K.; Stoll, D.; Meyers, G.; Thiel, H.J. (1997). "Serine protease of pestiviruses: determination of cleavage sites". J. Virol. 71: 5415–5422. PMID 9188613.
- ^ Xu, J.; Mendez, E.; Caron, P.R.; Lin, C.; Murcko, M.A.; Collett, M.S.; Rice, C.M. (1997). "Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication". J. Virol. 71: 5312–5322. PMID 9188600.
- ^ Tautz, N.; Kaiser, A.; Thiel, H.J. (2000). "NS3 serine protease of bovine viral diarrhea virus: characterization of active site residues, NS4A cofactor domain, and protease-cofactor interactions". Virology. 273: 351–363. doi:10.1006/viro.2000.0425. PMID 10915606.
External links
- Pestivirus+NS3+polyprotein+peptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)