Plasma kallikrein
| Plasma kallikrein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.34 | ||||||||
| CAS no. | 410538-33-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Plasma kallikrein (EC 3.4.21.34, serum kallikrein, kininogenin, kallikrein I, kallikrein II, kininogenase, kallikrein, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, panceatic kallikrein, onokrein P, dilminal D, depot-Padutin, urokallikrein, urinary kallikrein) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Selective cleavage of some Arg- and Lys- bonds, including Lys-Arg and Arg-Ser in (human) kininogen to release bradykinin
This enzyme is formed from plasma prokallikrein (Fletcher factor) by factor XIIa.
See also
References
- ^ Heimark, R.L. and Davie, E.W. (1981). "Bovine and human plasma prekallikrein". Methods Enzymol. 80: 157–172. doi:10.1016/s0076-6879(81)80016-x. PMID 6918767.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ McRae, B.J., Kurachi, K., Heimark, R.L., Fujikawa, K., Davie, E.W. and Powers, J.C. (1981). "Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates". Biochemistry. 20: 7196–7206. doi:10.1021/bi00528a022. PMID 6976185.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Silverberg, M. and Kaplan, A.P. (1988). "Prekallikrein". Methods Enzymol. 163: 85–95. doi:10.1016/0076-6879(88)63010-2. PMID 3237096.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Seidah, N.G., Ladenheim, R., Mbikay, M., Hamelin, J., Lutfalla, G., Rougeon, F., Lazure, C. and Chrétien, M. (1989). "The cDNA structure of rat plasma kallikrein". DNA. 8: 563–574. doi:10.1089/dna.1989.8.563. PMID 2598771.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Tsuda, Y., Teno, N., Okada, Y., Wanaka, K., Bohgaki, M., Hijikata-Okunomiya, A., Okamoto, U., Naito, T. and Okamoto, S. (1989). "Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein". Chem. Pharm. Bull. 37: 3108–3111. doi:10.1248/cpb.37.3108. PMID 2534361.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- Plasma+kallikrein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)