Plasma kallikrein
| Plasma kallikrein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.34 | ||||||||
| CAS no. | 410538-33-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Plasma kallikrein (EC 3.4.21.34, serum kallikrein, kininogenin, kallikrein I, kallikrein II, kininogenase, kallikrein, callicrein, glumorin, padreatin, padutin, kallidinogenase, bradykininogenase, panceatic kallikrein, onokrein P, dilminal D, depot-Padutin, urokallikrein, urinary kallikrein) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Selective cleavage of some Arg- and Lys- bonds, including Lys-Arg and Arg-Ser in (human) kininogen to release bradykinin
This enzyme is formed from plasma prokallikrein (Fletcher factor) by factor XIIa.
See also
References
- ^ Heimark, R.L.; Davie, E.W. (1981). "Bovine and human plasma prekallikrein". Methods Enzymol. 80: 157–172. doi:10.1016/s0076-6879(81)80016-x. PMID 6918767.
- ^ McRae, B.J.; Kurachi, K.; Heimark, R.L.; Fujikawa, K.; Davie, E.W.; Powers, J.C. (1981). "Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates". Biochemistry. 20: 7196–7206. doi:10.1021/bi00528a022. PMID 6976185.
- ^ Silverberg, M.; Kaplan, A.P. (1988). "Prekallikrein". Methods Enzymol. 163: 85–95. doi:10.1016/0076-6879(88)63010-2. PMID 3237096.
- ^ Seidah, N.G.; Ladenheim, R.; Mbikay, M.; Hamelin, J.; Lutfalla, G.; Rougeon, F.; Lazure, C.; Chrétien, M. (1989). "The cDNA structure of rat plasma kallikrein". DNA. 8: 563–574. doi:10.1089/dna.1989.8.563. PMID 2598771.
- ^ Tsuda, Y.; Teno, N.; Okada, Y.; Wanaka, K.; Bohgaki, M.; Hijikata-Okunomiya, A.; Okamoto, U.; Naito, T.; Okamoto, S. (1989). "Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein". Chem. Pharm. Bull. 37: 3108–3111. doi:10.1248/cpb.37.3108. PMID 2534361.
External links
- Plasma+kallikrein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)