SKF-89,145

SKF-89,145
Identifiers
	IUPAC name 4-(6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-4-yl)benzene-1,2-diol;
PubChem CID	10061214;
ChemSpider	8236766;
ChEMBL	ChEMBL1591046;
CompTox Dashboard (EPA)	DTXSID201017993 ;
Chemical and physical data
Formula	C14H15NO2S
Molar mass	261.339 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1ccc(cc1O)C2CN(C)Cc3sccc23;
	InChI InChI=1S/C14H15NO2S/c1-15-7-11(10-4-5-18-14(10)8-15)9-2-3-12(16)13(17)6-9/h2-6,11,16-17H,7-8H2,1H3; Key:SYHALWYYSDMSLE-UHFFFAOYSA-N;
	(verify)

SKF-89,145 is a drug which acts as a dopamine agonist selective for the D₁ subtype. The N-desmethyl derivative SKF-89,626 is also a selective D₁ agonist with similar potency and selectivity to SKF 89,145.^[1]

References

^ O'Boyle KM, Waddington JL (December 1987). "New substituted 1-phenyl-3-benzazepine analogues of SK&F 38393 and N-methyl-thienopyridine analogues of dihydroxynomifensine with selective affinity for the D-1 dopamine receptor in human post-mortem brain". Neuropharmacology. 26 (12): 1807–10. doi:10.1016/0028-3908(87)90139-0. PMID 3501846.

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[pmid3501846-1] O'Boyle KM, Waddington JL (December 1987). "New substituted 1-phenyl-3-benzazepine analogues of SK&F 38393 and N-methyl-thienopyridine analogues of dihydroxynomifensine with selective affinity for the D-1 dopamine receptor in human post-mortem brain". Neuropharmacology. 26 (12): 1807–10. doi:10.1016/0028-3908(87)90139-0. PMID 3501846.

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