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SKF77434 structure.png
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass295.375 g/mol g·mol−1
3D model (JSmol)

SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects. Unlike other D1 agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction.[1][2][3][4][5][6][7]


  1. ^ Grech, D. M.; Spealman, R. D.; Bergman, J. (1996). "Self-administration of D1 receptor agonists by squirrel monkeys". Psychopharmacology. 125 (2): 97–104. doi:10.1007/BF02249407. PMID 8783382.
  2. ^ Weed, M. R.; Paul, I. A.; Dwoskin, L. P.; Moore, S. E.; Woolverton, W. L. (1997). "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 29–38. PMID 9336305.
  3. ^ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2000). "Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434". The Journal of Pharmacology and Experimental Therapeutics. 293 (3): 1017–1026. PMID 10869406.
  4. ^ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2001). "Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys". Psychopharmacology. 157 (2): 208–216. doi:10.1007/s002130100779. PMID 11594448.
  5. ^ Mutschler, N. H.; Bergman, J. (2002). "Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys". Psychopharmacology. 160 (4): 362–370. doi:10.1007/s00213-001-0976-z. PMID 11919663.
  6. ^ Desai, R. I.; Terry, P.; Katz, J. L. (2005). "A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice". Pharmacology Biochemistry and Behavior. 81 (4): 843–848. doi:10.1016/j.pbb.2005.06.006. PMID 16000217.
  7. ^ Katz, J. L.; Kopajtic, T. A.; Terry, P. (2006). "Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats". Behavioural Pharmacology. 17 (4): 303–309. doi:10.1097/01.fbp.0000205015.67079.f7. PMID 16914948.