TSPAN4

TSPAN4
Identifiers
Aliases	TSPAN4, NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4, tetraspanin 4
External IDs	OMIM: 602644; MGI: 1928097; HomoloGene: 2453; GeneCards: TSPAN4; OMA:TSPAN4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	867,116 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,073,340 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right lung; ; left uterine tube; ; right ovary; ; canal of the cervix; ; left ovary; ; body of uterus; ; subcutaneous adipose tissue; ; upper lobe of left lung; ; tibial nerve;
	Top expressed in
	stroma of bone marrow; ; decidua; ; calvaria; ; gastrula; ; endothelial cell of lymphatic vessel; ; internal carotid artery; ; external carotid artery; ; right kidney; ; adrenal gland; ; choroid plexus of fourth ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	antigen binding; integrin binding; protein binding;
Cellular component	integral component of membrane; vesicle; plasma membrane; integral component of plasma membrane; membrane; focal adhesion;
Biological process	cell surface receptor signaling pathway; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	7106
	64540
	ENSG00000214063
	ENSMUSG00000025511
	O14817
	Q9DCK3
NM_001025234; NM_001025235; NM_001025236; NM_001025237; NM_001025238;
	NM_001025239; NM_003271
	NM_001252588; NM_053082
NP_001020405; NP_001020406; NP_001020407; NP_001020408; NP_001020409;
	NP_001020410; NP_003262
NP_001239517; NP_444312; NP_001390284; NP_001390285; NP_001390286;
	NP_001390287
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.^[5]^[6]

Template:PBB Summary

Interactions

TSPAN4 has been shown to interact with CD9,^[5] ITGA6,^[5] CD29,^[5] CD49c^[5] and CD81.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000214063 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025511 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c ^d ^e ^f Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Dec 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J Biol Chem. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: TSPAN4 tetraspanin 4".

v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

Interactions

References

Further reading