Cucumisin
| Cucumisin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.25 | ||||||||
| CAS no. | 82062-89-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cucumisin (EC 3.4.21.25, euphorbain, solanain, hurain, tabernamontanain) is an enzyme.[1][2][3][4][5][6][7] This enzyme catalyzes hydrolysis of a wide range of proteins. It has been identified as an allergen in humans.[8]
This enzyme is isolated from the sarcocarp of the musk melon (Cucumis melo).
References
[edit]- ^ Greenberg DM, Winnick T (1940). "Plant proteases. I. Activation-inhibition reactions". J. Biol. Chem. 135: 761–773.
- ^ Jaffé WG (1943). "Hurain, a new plant protease from Hura crepitans". J. Biol. Chem. 149: 1–7.
- ^ Jaffé WG (1943). "A new vegetable proteolytic enzyme of the papain class". Rev. Brasil Biol. 3: 149–157.
- ^ Kaneda M, Tominaga N (December 1975). "Isolation and characterization of a proteinase from the sarcocarp of melon fruit". Journal of Biochemistry. 78 (6): 1287–96. PMID 5423.
- ^ Kaneda M, Ohmine H, Yonezawa H, Tominaga N (March 1984). "Amino acid sequence around the reactive serine of cucumisin from melon fruit". Journal of Biochemistry. 95 (3): 825–9. PMID 6427203.
- ^ Lynn KR, Clevette-Radford NA (1985). "Two proteases from the latex of Elaeophorbia drupifera". Phytochemistry. 24: 2843–2845. doi:10.1016/0031-9422(85)80011-x.
- ^ Kaneda N, Minematsu Y, Powers JC, Tominaga N (1986). "Specificity of cucumisin in hydrolysis of peptide thiobenzyl esters". Agric. Biol. Chem. 50: 1075–1076. doi:10.1271/bbb1961.50.1075.
- ^ Sankian M, Talebi F, Moghadam M, Vahedi F, Jabbari Azad F, Varasteh A (2011). "Molecular Cloning and Expression of Cucumisin (Cuc m 1), a Subtilisin-like Protease of Cucumis melo in Escherichia coli". Allergology International. 60 (1): 61–67. doi:10.2332/allergolint.10-OA-0195.
External links
[edit]- Cucumisin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
