Keratinocyte growth factor: Difference between revisions
Content deleted Content added
m moved Keratinocyte Growth Factor to Keratinocyte growth factor: caps |
ref, nav |
||
| Line 1: | Line 1: | ||
The '''Keratinocyte Growth Factor''' (KGF) is a [[growth factor]] present in the [[epithelialization]]-phase of [[wound healing]]. In this phase, [[keratinocytes]] are covering the wound, forming the [[epithelium]]. |
The '''Keratinocyte Growth Factor''' (KGF) is a [[growth factor]] present in the [[epithelialization]]-phase of [[wound healing]]. In this phase, [[keratinocytes]] are covering the wound, forming the [[epithelium]]. |
||
KGF, also referred to as FGF7 is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b). For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin. |
KGF, also referred to as FGF7 is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b).<ref name="pmid18575591">{{cite journal |author=Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A |title=Silencing of keratinocyte growth factor receptor restores 5-fluorouracil and tamoxifen efficacy on responsive cancer cells |journal=PLoS ONE |volume=3 |issue=6 |pages=e2528 |year=2008 |pmid=18575591 |pmc=2424182 |doi=10.1371/journal.pone.0002528 |url=http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002528}}</ref> For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin. |
||
There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner. |
There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner. |
||
==References== |
|||
{{reflist}} |
|||
==External links== |
==External links== |
||
| Line 13: | Line 16: | ||
{{medicine-stub}} |
{{medicine-stub}} |
||
{{Growth factors}} |
|||
Revision as of 00:02, 14 October 2008
The Keratinocyte Growth Factor (KGF) is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium.
KGF, also referred to as FGF7 is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b).[1] For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.
There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.
References
- ^ Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A (2008). "Silencing of keratinocyte growth factor receptor restores 5-fluorouracil and tamoxifen efficacy on responsive cancer cells". PLoS ONE. 3 (6): e2528. doi:10.1371/journal.pone.0002528. PMC 2424182. PMID 18575591.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
External links
- http://www-personal.umich.edu/~lpt/fgf/1fq9_files/side.jpg
- http://www-personal.umich.edu/~lpt/fgf/1fq9.htm
 | This medical article is a stub. You can help Wikipedia by expanding it. |