FGF6

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Fibroblast growth factor 6
Identifiers
Symbols FGF6 ; HBGF-6; HST2
External IDs OMIM134921 MGI95520 HomoloGene10870 GeneCards: FGF6 Gene
RNA expression pattern
PBB GE FGF6 208417 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2251 14177
Ensembl ENSG00000111241 ENSMUSG00000000183
UniProt P10767 P21658
RefSeq (mRNA) NM_020996 NM_010204
RefSeq (protein) NP_066276 NP_034334
Location (UCSC) Chr 12:
4.54 – 4.55 Mb
Chr 6:
127.02 – 127.02 Mb
PubMed search [1] [2]

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.[1][2]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.[2]

References[edit]

  1. ^ Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM (Jun 2006). "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family". J Biol Chem 281 (23): 15694–700. doi:10.1074/jbc.M601252200. PMC 2080618. PMID 16597617. 
  2. ^ a b "Entrez Gene: FGF6 fibroblast growth factor 6". 

Further reading[edit]