Placental growth factor: Difference between revisions
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'''Placental growth factor''' or '''vascular endothelial growth factor-related protein''' is a member of the [[VEGF sub-family]]. In humans, placental growth factor is encoded by the ''PGF'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PGF placental growth factor, vascular endothelial growth factor-related protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5228| accessdate = }}</ref><ref name="pmid7681160">{{cite journal | author = Maglione D, Guerriero V, Viglietto G, Ferraro MG, Aprelikova O, Alitalo K, Del Vecchio S, Lei KJ, Chou JY, Persico MG | title = Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14 | journal = Oncogene | volume = 8 | issue = 4 | pages = 925–31 | year = 1993 | month = April | pmid = 7681160 | doi = | url = | issn = }}</ref> |
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PGF expression within human [[atherosclerosis|atherosclerotic lesions]] is associated with plaque inflammation and neovascular growth.<sup>2,3</sup> |
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| ⚫ | Serum levels of PGF and [[Soluble fms-like tyrosine kinase-1|sFlt-1]] (soluble fms-like tyrosine kinase-1, also known as soluble VEGF receptor-1) are altered in women with [[pre-eclampsia|preeclampsia]]. Studies show that in both early and late onset preeclampsia, maternal serum levels of sFlt-1 are higher and PGF lower in women presenting with preeclampsia. In addition, placental sFlt-1 levels were significantly increased and PGF decreased in women with preeclampsia as compared to those with uncomplicated pregnancies. This suggests that placental concentrations of sFlt-1 and PGF mirror the maternal serum changes. This is consistent with the view that the [[placenta]] is the main source of sFlt-1 and PGF during pregnancy.<sup>1</sup> |
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| ⚫ | Placental growth factor (PGF) is a member of the VEGF ([[vascular endothelial growth factor]]) sub-family - a key molecule in [[angiogenesis]] and [[vasculogenesis]], in particular during [[embryogenesis]]. The main source of PGF during pregnancy is the placental [[trophoblast]]. PGF is also expressed in many other tissues, including the villous trophoblast.<ref name="pmid18648513">{{cite journal | author = Khalil A, Muttukrishna S, Harrington K, Jauniaux E | title = Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders | journal = PLoS ONE | volume = 3 | issue = 7 | pages = e2766 | year = 2008 | pmid = 18648513 | pmc = 2447877 | doi = 10.1371/journal.pone.0002766 | url = | issn = }}</ref> |
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== Clinical significance == |
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1. Khalil A, Muttukrishna S, Harrington K, Jauniaux E, 2008 Effect of Antihypertensive Therapy with Alpha Methyldopa on Levels of Angiogenic Factors in Pregnancies with [[Hypertension|Hypertensive Disorders]]. [[PLoS ONE]] 3(7): e2766. doi:10.1371/journal.pone.0002766 |
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Placental growth factor-expression within human [[atherosclerosis|atherosclerotic]] lesions is associated with [[atheroma|plaque]] inflammation and [[neovascularization|neovascular growth]].<ref name="pmid15911697">{{cite journal | author = Khurana R, Moons L, Shafi S, Luttun A, Collen D, Martin JF, Carmeliet P, Zachary IC | title = Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation | journal = Circulation | volume = 111 | issue = 21 | pages = 2828–36 | year = 2005 | month = May | pmid = 15911697 | doi = 10.1161/CIRCULATIONAHA.104.495887 | url = }}</ref><ref name="pmid18452647">{{cite journal | author = Shibuya M | title = Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis | journal = BMB Rep | volume = 41 | issue = 4 | pages = 278–86 | year = 2008 | month = April | pmid = 18452647 | doi = | url = http://www.bmbreports.org/fulltext/bmbreports/view.php?vol=41&page=278 | issn = }}</ref> |
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PGF expression within human [[atherosclerosis|atherosclerotic lesions]] is associated with plaque inflammation and neovascular growth.<ref name="pmid15911697">{{cite journal | author = Khurana R, Moons L, Shafi S, Luttun A, Collen D, Martin JF, Carmeliet P, Zachary IC | title = Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation | journal = Circulation | volume = 111 | issue = 21 | pages = 2828–36 | year = 2005 | month = May | pmid = 15911697 | doi = 10.1161/CIRCULATIONAHA.104.495887 | url = | issn = }}</ref><ref name="pmid18452647">{{cite journal | author = Shibuya M | title = Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis | journal = BMB Rep | volume = 41 | issue = 4 | pages = 278–86 | year = 2008 | month = April | pmid = 18452647 | doi = | url = | issn = }}</ref> |
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3.Shibuya M (April 2008). "Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis". BMB Rep 41 (4): 278–86. PMID 18452647. http://www.bmbreports.org/fulltext/bmbreports/view.php?vol=41&page=278. |
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| ⚫ | Serum levels of PGF and [[Soluble fms-like tyrosine kinase-1|sFlt-1]] (soluble fms-like tyrosine kinase-1, also known as soluble VEGF receptor-1) are altered in women with [[pre-eclampsia|preeclampsia]]. Studies show that in both early and late onset preeclampsia, maternal serum levels of sFlt-1 are higher and PGF lower in women presenting with preeclampsia. In addition, placental sFlt-1 levels were significantly increased and PGF decreased in women with preeclampsia as compared to those with uncomplicated pregnancies. This suggests that placental concentrations of sFlt-1 and PGF mirror the maternal serum changes. This is consistent with the view that the [[placenta]] is the main source of sFlt-1 and PGF during pregnancy.<sup>1</sup> |
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{{Reflist}} |
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==Further reading== |
==Further reading== |
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Revision as of 07:41, 12 December 2010
Template:PBB Placental growth factor or vascular endothelial growth factor-related protein is a member of the VEGF sub-family. In humans, placental growth factor is encoded by the PGF gene.[1][2]
Placental growth factor (PGF) is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast.[3]
Clinical significance
Placental growth factor-expression within human atherosclerotic lesions is associated with plaque inflammation and neovascular growth.[4][5]
PGF expression within human atherosclerotic lesions is associated with plaque inflammation and neovascular growth.[4][5]
Serum levels of PGF and sFlt-1 (soluble fms-like tyrosine kinase-1, also known as soluble VEGF receptor-1) are altered in women with preeclampsia. Studies show that in both early and late onset preeclampsia, maternal serum levels of sFlt-1 are higher and PGF lower in women presenting with preeclampsia. In addition, placental sFlt-1 levels were significantly increased and PGF decreased in women with preeclampsia as compared to those with uncomplicated pregnancies. This suggests that placental concentrations of sFlt-1 and PGF mirror the maternal serum changes. This is consistent with the view that the placenta is the main source of sFlt-1 and PGF during pregnancy.1
References
- ^ "Entrez Gene: PGF placental growth factor, vascular endothelial growth factor-related protein".
- ^ Maglione D, Guerriero V, Viglietto G, Ferraro MG, Aprelikova O, Alitalo K, Del Vecchio S, Lei KJ, Chou JY, Persico MG (1993). "Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14". Oncogene. 8 (4): 925–31. PMID 7681160.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Khalil A, Muttukrishna S, Harrington K, Jauniaux E (2008). "Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders". PLoS ONE. 3 (7): e2766. doi:10.1371/journal.pone.0002766. PMC 2447877. PMID 18648513.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ a b Khurana R, Moons L, Shafi S, Luttun A, Collen D, Martin JF, Carmeliet P, Zachary IC (2005). "Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation". Circulation. 111 (21): 2828–36. doi:10.1161/CIRCULATIONAHA.104.495887. PMID 15911697.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) Cite error: The named reference "pmid15911697" was defined multiple times with different content (see the help page). - ^ a b Shibuya M (2008). "Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis". BMB Rep. 41 (4): 278–86. PMID 18452647.
{{cite journal}}: Unknown parameter|month=ignored (help) Cite error: The named reference "pmid18452647" was defined multiple times with different content (see the help page).
Further reading
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