Macro-haplogroup L: Difference between revisions

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===North Africa===
===North Africa===
Haplogroup L is also found at moderate frequencies in [[North Africa]]. For example, the various [[Berber people|Berber populations]] have frequencies of haplogroup L lineages that range from 3% to 45%.<ref>{{cite journal |author=Cherni L, Loueslati BY, Pereira L, Ennafaâ H, Amorim A, El Gaaied AB |title=Female gene pools of Berber and Arab neighboring communities in central Tunisia: microstructure of mtDNA variation in North Africa |journal=Human Biology |volume=77 |issue=1 |pages=61–70 | date=February 2005 |pmid=16114817 |doi=10.1353/hub.2005.0028}}</ref><ref>{{cite journal |vauthors=Turchi C, Buscemi L, Giacchino E, etal |title=Polymorphisms of mtDNA control region in Tunisian and Moroccan populations: an enrichment of forensic mtDNA databases with Northern Africa data |journal=Forensic Science International: Genetics |volume=3 |issue=3 |pages=166–72 | date=June 2009 |pmid=19414164 |doi=10.1016/j.fsigen.2009.01.014}}</ref>
Haplogroup L is also found at moderate frequencies in [[North Africa]]. For example, the various [[Berber people|Berber populations]] have frequencies of haplogroup L lineages that range from 3% to 45%.<ref>{{cite journal |author=Cherni L, Loueslati BY, Pereira L, Ennafaâ H, Amorim A, El Gaaied AB |title=Female gene pools of Berber and Arab neighboring communities in central Tunisia: microstructure of mtDNA variation in North Africa |journal=Human Biology |volume=77 |issue=1 |pages=61–70 | date=February 2005 |pmid=16114817 |doi=10.1353/hub.2005.0028}}</ref><ref>{{cite journal |vauthors=Turchi C, Buscemi L, Giacchino E, etal |title=Polymorphisms of mtDNA control region in Tunisian and Moroccan populations: an enrichment of forensic mtDNA databases with Northern Africa data |journal=Forensic Science International: Genetics |volume=3 |issue=3 |pages=166–72 | date=June 2009 |pmid=19414164 |doi=10.1016/j.fsigen.2009.01.014}}</ref>
Haplogroup L has also been found at a small frequency of 2.2% in [[Berber Jews|North African Jews]] from Morocco, Tunisia and Libya. Frequency was the highest in Libyan Jews 3.6%.<ref name="plosone.org">{{cite journal |vauthors=Behar DM, Metspalu E, Kivisild T, etal |title=Counting the founders: the matrilineal genetic ancestry of the Jewish Diaspora |journal=PLoS ONE |volume=3 |issue=4 |pages=e2062 |year=2008 |pmid=18446216 |pmc=2323359 |doi=10.1371/journal.pone.0002062 |url= |editor1-last=MacAulay |editor1-first=Vincent}}</ref> Moroccan Arabs have more elevated SSA maternal admixture at around 21% to 36% Via L-mtDNA sequences, Highest frequencies of L-mtDNA is reported to Moroccan Arabs of The Surrounding area of El jadida at 36% and this admixture is largely ascribed to the [[trans-Saharan slave trade]].<ref>[http://www.biomedcentral.com/1471-2148/10/138 Harich et al 2010]</ref>
Haplogroup L has also been found at a small frequency of 2.2% in [[Berber Jews|North African Jews]] from Morocco, Tunisia and Libya. Frequency was the highest in Libyan Jews 3.6%.<ref name="plosone.org">{{cite journal |vauthors=Behar DM, Metspalu E, Kivisild T, etal |title=Counting the founders: the matrilineal genetic ancestry of the Jewish Diaspora |journal=PLoS ONE |volume=3 |issue=4 |pages=e2062 |year=2008 |pmid=18446216 |pmc=2323359 |doi=10.1371/journal.pone.0002062 |url= |editor1-last=MacAulay |editor1-first=Vincent}}</ref> Moroccan Arabs have more elevated SSA maternal admixture at around 21% to 36% Via L-mtDNA sequences, Highest frequencies of L-mtDNA is reported to Moroccan Arabs of The Surrounding area of El jadida at 36% and this admixture is largely ascribed to the [[trans-Saharan slave trade]].<ref>{{citeweb|title=The trans-Saharan slave trade - clues from interpolation analyses and high-resolution characterization of mitochondrial DNA lineages|url=http://www.biomedcentral.com/1471-2148/10/138|publisher=[[BMC Evolutionary Biology]]|author=Harich et al 2010|date=May 10, 2010|accessdate=May 27, 2016}}</ref>


===West Asia===
===West Asia===

Revision as of 01:31, 28 May 2016

Haplogroup L
Time of origin151,600–233,600 YBP[1]
Place of originEastern Africa[2]
DescendantsL0, L1-6

In human mitochondrial genetics, L is the mitochondrial DNA macro-haplogroup that is at the root of the human mtDNA phylogenetic tree. As such, it represents the most ancestral mitochondrial lineage of all currently living modern humans.

Macro-haplogroup L's origin is connected with Mitochondrial Eve, and thus, is believed to suggest an ultimate African origin of modern humans. Its major sub-clades include L0, L1, L2, L3, L4, L5 and L6, with all non-Africans exclusively descended from just haplogroup L3.

Haplogroup L3 descendants notwithstanding, the designation "haplogroup L" is typically used to designate the family of mtDNA clades that are most frequently found in Sub-Saharan Africa. However, all non-African haplogroups coalesce onto either haplogroup M or haplogroup N, and both these macrohaplogroups are simply sub-branches of haplogroup L3. Consequently, L in its broadest definition is really a paragroup containing all of modern humanity, and all human mitochondrial DNA from around the world are subclades of haplogroup L. Haplogroups M and N are sometimes referred to as haplogroups L3M and L3N respectively. Mitochondrial Eve is defined as the female human ancestor who is the most recent common ancestor of the most deep-rooted lineages of humanity: haplogroups L, L0 and L1-6.

Haplogroup L phylogeny
mtEve
 L0 

L0d

L0k

L0f

L0a

L0b

 L1─6 
L1

L1b

L1c

L5

L2

L6

L3

M

N

L4

Origin

Studies of human mitochondrial (mt) DNA genomes demonstrate that the root of the human phylogenetic tree occurs in sub-Saharan Africa. The data suggest that Tanzanians have high genetic diversity and possess ancient mtDNA haplogroups, some of which are either rare or absent in other regions of Africa. A large and diverse human population has persisted in eastern Africa and that region may have been an ancient source of dispersion of modern humans both within and outside of Africa.[2]

Mitochondrial Eve is the ancestor of this macro-haplogroup and she is estimated to have lived approximately 190,000 years ago.[1]

Distribution

Putting aside its sub-branches, haplogroups M and N, L haplogroups are predominant all over sub-Saharan Africa; L is at 96-100%, apart from spreading areas of Afroasiatic languages, where it is lower. Low frequencies are in North Africa, Arabian Peninsula, Middle East and Europe.

Sub-Saharan Africa

With the exception of a number of lineages that returned to Africa from Eurasia after the out of Africa migration, all Sub-Saharan African lineages belong to haplogroup L. The "back-to-Africa" haplogroups including U6, X1 and possibly M1 have returned to Africa possibly as far back as 45,000 years ago.[3] Haplogroup H, which is common among Berbers, is also believed to have entered Africa from Europe during the post-glacial expansion.[4]

The mutations that are used to identify the basal lineages of haplogroup L, are ancient and may be 150,000 years old. The deep time depth of these lineages entails that substructure of this haplogroup within Africa is complex and, at present, poorly understood.[5] The first split within haplogroup L occurred 140-200kya, with the mutations that define macrohaplogroups L0 and L1-6. These two haplogroups are found throughout Africa at varying frequencies and thus exhibit an entangled pattern of mtDNA variation. However the distribution of some subclades of haplogroup L is structured around geographic or ethnic units. For example, the deepest clades of haplogroup L0, L0d and L0k are almost exclusively restricted to the Khoisan of southern Africa. L0d has also been detected among the Sandawe of Tanzania, which suggests an ancient connection between the Khoisan and East African populations.[6]

Macro-haplogroup L (mtDNA) composition within Africa. Approximate frequencies in: 1. North Africa.[7][8] 2. Sudan.[8] 3. Ethiopia.[8][9] 4. West Africa.[7] 5. East Africa (Kenya, Uganda, Tanzania).[8][10][11] 6. Southeast Africa (Mozambique).[12] 7. Native Southern Africans (!Xung, !Kung and Khwe khoisans).[10][13] 8. Mbenga Pygmies (Baka, Bi-Aka and Ba-Kola).[10][14] 9. Ba-Mbuti Pygmies.[10] 10. Hadza/Sandawe.[10]

North Africa

Haplogroup L is also found at moderate frequencies in North Africa. For example, the various Berber populations have frequencies of haplogroup L lineages that range from 3% to 45%.[15][16] Haplogroup L has also been found at a small frequency of 2.2% in North African Jews from Morocco, Tunisia and Libya. Frequency was the highest in Libyan Jews 3.6%.[17] Moroccan Arabs have more elevated SSA maternal admixture at around 21% to 36% Via L-mtDNA sequences, Highest frequencies of L-mtDNA is reported to Moroccan Arabs of The Surrounding area of El jadida at 36% and this admixture is largely ascribed to the trans-Saharan slave trade.[18]

West Asia

See also: Archaeogenetics of the Near East

Haplogroup L is also found in West Asia at low to moderate frequencies, most notably in Yemen where frequencies as high as 60% have been reported.[19] It is also found at 15.50% in Bedouins from Israel, 13.68% in Palestinians, 12.55% in Jordania, 9.48% in Iraq, 9.15% in Syria, 6.66% in Saudi Arabia, 2.84% in Lebanon, 2.60% in Druzes from Israel, 2.44% in Kurds and 1.76% in Turks.[17][20][21]

Europe

See also: Genetic history of the human population of Europe

In Europe, haplogroup L is found at low frequencies, typically less than 1% with the exception of Iberia where frequencies as high as 18.2% have been reported and some regions of Italy where frequencies between 2 and 3% have been found.

Overall frequency in Iberia is higher in Portugal than in Spain where frequencies only high in the south and west of the country. Increasing frequencies are observed for Galicia (3.26%) and northern Portugal (3.21%), through the center (5.02%) and to the south of Portugal (11.38%).[22] Relatively high frequencies of 7.40% and 8.30% was also reported respectively in South Iberia, in the present population of Huelva and Priego de Cordoba by Casas et al. 2006.[23] Significant frequencies were also found in the Autonomous regions of Portugal, with L haplogroups constituting about 13% of the lineages in Madeira and 3.4% in the Azores. In the Spanish archipelago of Canary Islands, frequencies have been reported at 6.6%.[24] According to some researchers L lineages in Iberia are associated to Islamic invasions, while for others it may be due to more ancient processes as well as more recent ones through the introduction of these lineages by means of the modern slave trade. The highest frequency (18.2%) of Sub-Saharan lineages found so far in Europe were observed by Alvarez et al. 2010 in the comarca of Sayago which is according to the authors "comparable to that described for the South of Portugal".[25][26]

In Italy, Haplogroup L lineages are present in some regions at frequencies between 2 and 3% in Latium (2.90%), parts of Tuscany,[20] Basilicata and Sicily.[27]

The Americas

Haplogroup L lineages are found in the African diaspora of the Americas as well as indigenous Americans. Haplogroup L lineages are predominant among African Americans, Afro-Caribbeans and Afro-Latin-Americans. In Brazil, Pena et al. report that 85% of self-identified Afro-Brazilians have Haplogroup L mtDNA sequences.[28] Haplogroup L lineages are also found at moderate frequencies in self-identified White Brazilians. Alves Silva reports that 28% of a sample of White Brazilians belong to haplogroup L.[29] In Argentina, a minor contribution of African lineages was observed throughout the country.[30] Haplogroup L lineages were also reported at 8% in Colombia,[31] and at 4.50% in North-Central Mexico.[32] In North America, haplogroup L lineages were reported at a frequency of 0.90% in White Americans of European ancestry.[33]

Haplogroup L Frequencies (> 1%)

Region Population or Country Number tested Reference %
East Africa Somalis 26 Watson et al. (1997) 50.00%
East Africa Sudan 112 Afonso et al. (2008) 72.50%
East Africa Ethiopia 270 Kivisild et al. (2004) 52.20%
North Africa Libya (Jews) 83 Behar et al. (2008) 3.60%
North Africa Tunisia (Jews) 37 Behar et al. (2008) 2.20%
North Africa Morocco (Jews) 149 Behar et al. (2008) 1.34%
North Africa Tunisia 64 Turchi et al. (2009) 48.40%
North Africa Tunisia (Takrouna) 33 Frigi et al. (2006) 3.03%
North Africa Tunisia (Zriba) 50 Turchi et al. (2009) 8.00%
North Africa Morocco 56 Turchi et al. (2009) 26.80%
North Africa Morocco (Berbers) 64 Turchi et al. (2009) 3.20%
North Africa Algeria (Mozabites) 85 Turchi et al. (2009) 12.90%
North Africa Algeria 47 Turchi et al. (2009) 20.70%
Europe Italy (Latium) 138 Achilli et al. (2007) 2.90%
Europe Italy (Volterra) 114 Achilli et al. (2007) 2.60%
Europe Italy (Basilicata) 92 Ottoni et al. (2009) 2.20%
Europe Italy (Sicily) 154 Ottoni et al. (2009) 2.00%
Europe Spain 312 Alvarez et al. (2007) 2.90%
Europe Spain (Galicia) 92 Pereira et al. (2005) 3.30%
Europe Spain (North East) 118 Pereira et al. (2005) 2.54%
Europe Spain (Priego de Cordoba) 108 Casas et al. (2006) 8.30%
Europe Spain (Zamora) 214 Alvarez et al. (2010) 4.70%
Europe Spain (Sayago) 33 Alvarez et al. (2010) 18.18%
Europe Spain (Catalonia) 101 Alvarez-Iglesias et al. (2009) 2.97%
Europe South Iberia 310 Casas et al. (2006) 7.40%
Europe Spain (Canaries) 300 Brehm et al. (2003) 6.60%
Europe Spain (Balearic Islands) 231 Picornell et al. (2005) 2.20%
Europe Portugal 594 Achilli et al. (2007) 6.90%
Europe Portugal (North) 188 Achilli et al. (2007) 3.19%
Europe Portugal (Central) 203 Achilli et al. (2007) 6.40%
Europe Portugal (South) 203 Achilli et al. (2007) 10.84%
Europe Portugal 549 Pereira et al. (2005) 5.83%
Europe Portugal (North) 187 Pereira et al. (2005) 3.21%
Europe Portugal (Central) 239 Pereira et al. (2005) 5.02%
Europe Portugal (South) 123 Pereira et al. (2005) 11.38%
Europe Portugal (Madeira) 155 Brehm et al. (2003) 12.90%
Europe Portugal (Açores) 179 Brehm et al. (2003) 3.40%
Europe Portugal (Alcacer do Sal) 50 Pereira et al. (2010) 22.00%
Europe Portugal (Coruche) 160 Pereira et al. (2010) 8.70%
Europe Portugal (Pias) 75 Pereira et al. (2010) 3.90%
West Asia Yemen 115 Kivisild et al. (2004) 45.70%
West Aasia Yemen (Jews) 119 Behar et al. (2008) 16.81%
West Asia Bedouins (Israel) 58 Behar et al. (2008) 15.50%
West Asia Palestinians (Israel) 117 Achilli et al. (2007) 13.68%
West Asia Jordania 494 Achilli et al. (2007) 12.50%
West Asia Iraq 116 Achilli et al. (2007) 9.48%
West Asia Syria 328 Achilli et al. (2007) 9.15%
West Asia Saudi Arabia 120 Abu-Amero et al. (2007) 6.66%
West Asia Lebanon 176 Achilli et al. (2007) 2.84%
West Asia Druzes (Israel) 77 Behar et al. (2008) 2.60%
West Asia Kurds 82 Achilli et al. (2007) 2.44%
West Asia Turkey 340 Achilli et al. (2007) 1.76%
South America Colombia (Antioquia) 113 Bedoya et al. (2006) 8.00%
North America Mexico (North-Central) 223 Green et al. (2000) 4.50%
South America Argentina 246 Corach et al. (2009) 2.03%

See also

References

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  30. ^ Bobillo MC, Zimmermann B, Sala A, et al. (August 2009). "Amerindian mitochondrial DNA haplogroups predominate in the population of Argentina: towards a first nationwide forensic mitochondrial DNA sequence database". International Journal of Legal Medicine. 124 (4): 263–8. doi:10.1007/s00414-009-0366-3. PMID 19680675.
  31. ^ Bedoya G, Montoya P, García J, et al. (May 2006). "Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate". Proceedings of the National Academy of Sciences of the United States of America. 103 (19): 7234–9. doi:10.1073/pnas.0508716103. PMC 1464326. PMID 16648268.
  32. ^ Green LD, Derr JN, Knight A (March 2000). "mtDNA affinities of the peoples of North-Central Mexico". American Journal of Human Genetics. 66 (3): 989–98. doi:10.1086/302801. PMC 1288179. PMID 10712213.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  33. ^ Gonçalves VF, Prosdocimi F, Santos LS, Ortega JM, Pena SD (2007). "Sex-biased gene flow in African Americans but not in American Caucasians". Genetics and Molecular Research. 6 (2): 256–61. PMID 17573655.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6  
L1 L2   L3     L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T
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