Ross Barnes of the Boston Red Stockings concludes in the top 5 in 11 different offensive categories. He leads the NA in runs scored, total bases and times on base. He is second in on-base percentage, doubles, triples and walks. He finishes third in batting average (.401) and hits. He places 4th in slugging percentage and 5th in runs batted in.
Rynie Wolters of the New York Mutuals leads the league in games started, complete games, and innings pitched and ties for the league lead with 1 shutout. He also leads the NA with 44 RBI while batting .370.
May 4 – In the very first major league game ever played, the National Association begins play at Hamilton Field in Fort Wayne, Indiana, with Forest City of Cleveland visiting the Kekiongas of Fort Wayne. Fort Wayne wins 2–0 behind the pitching of Bobby Mathews, the lowest scoring game of the season. Deacon White gets the first hit, while Joe McDermott, who will only have 11 hits and four runs batted in his career, drives in the first run in professional baseball history with a single in the second inning, scoring Bill Lennon. In the seventh inning, Lennon also became the first catcher in major league history to throw a runner out trying to steal second. Ironically, neither McDermott, Lennon, nor even the Kekiongas would finish the season.
May 8 – Ezra Sutton of the Cleveland Forest Citys hits the first home run in professional baseball history in the fourth inning against the Chicago White Stockings. For good measure, Sutton adds a second home run in the seventh inning, but Cleveland falls to the White Stockings, 14–12.
May 9 - Esteban Enrique Bellán becomes he first Hispanic player in Major League Baseball history. The 21-year old Cuban infielder will play as Steve Bellan for the Troy Haymakers of the National Association.
May 20 – In Boston, Mort Rogers introduces a scorecard with a picture of Harry Wright on the front. Each Red Stockings home game would feature a different player so that spectators could collect them and have a full set of Boston's players by season's end. This marketing strategy would be used throughout the 19th century and would ultimately evolve into Tobacco cards and, eventually, Baseball cards.
June 19 – The Fort Wayne Kekiongas, leading the Troy Haymakers 6–3 after six innings at Troy, refuse to allow another ball to be used after the game ball becomes ripped because of the reputation of the Haymakers using illegal balls in the past. The umpire (Isaac Leroy or Ed Tighe depending on the source), after five full minutes of ordering Fort Wayne back on the field, calls the game a 9–0 forfeit in favor of the Haymakers.
July 3 – The New York Mutuals lose at Troy 37–16. Even though it is customary to allow the visiting team to choose which ball to use, Troy captain Bill Craver refuses to play unless their ball is used. Heated words are exchanged throughout, with the Mutuals even being threatened with bats. Mutuals captain Bob Ferguson is convinced the ball used is not legal. This game will set the stage for the rematch on July 13 at the Union Grounds in Brooklyn.
July 6 – The first game between a black team and a white team is played as the black Uniques defeat the white Alerts 17–16 in Chicago.
July 13 – Brooklyn police are forced to draw their firearms to stop the crowd from attacking the Troy Haymakers following several altercations between the Haymakers and the New York Mutuals players and officials after Troy's 9–7 win over the Mutuals.
August 21 – The amateur champion Star Club of Brooklyn beats the Northwest amateur champion Aetnas of Chicago 4–3 in Chicago as Star pitcher Candy Cummings drives in the winning run in the 9th inning.
August 29 – The Brooklyn Eckfords replace the Fort Wayne Kekiongas in the NA after the Kekiongas lose most of their players to defection and expulsion. Fort Wayne's unplayed games will be declared forfeits in the official standings. The Eckfords will officially join the National Association for the 1872 season.