January 6 – New York Giants President Charles A. Stoneham dies of Bright's disease. He was the last surviving member of the trio that purchased the team in 1919. His son, Horace Stoneham, is elected the team's new president. Stoneham‚ 32‚ will remain president for the next 40 years before selling the team in 1976.
April 14 – Opening day, the New York Yankees are shut out, 1–0, by Bobo Newsom and the Washington Senators.
In St. Louis, the Cardinals' Eddie Morgan becomes the first to hit a pinch-hit home run in his first major league at bat. Morgan connects on the very first pitch he sees in the 7th inning. The Cubs win, 12-7.
In St. Louis‚ Roy Parmelee‚ former New York Giants pitcher‚ beats Carl Hubbell, 2–1, in a seventeen inning duel. The game is scoreless until the 12th when the Giants score a run‚ but the Cardinals match it in the bottom of the 12th. Parmelee allows just six hits in 17 innings‚ while Hubbell gives up 11.
May 3 – Joe DiMaggio makes his major league debut in left field in the New York Yankees' 14–5 victory over the St. Louis Browns. DiMaggio goes three-for-six- with a triple, an RBI and three runs scored.
May 10 – The New York Yankees defeat the Philadelphia Athletics, 7–2. With a loss by the Boston Red Sox to the Washington Senators, the Yankees take over first place in the American League. They remain in first place for the rest of the season, winning the pennant by 19.5 games over the Detroit Tigers.
May 24 – The New York Yankees defeat the Philadelphia Athletics 25–2. Second basemanTony Lazzeri has eleven RBIs in the game via two grand slams and a third home run and a triple. With his last blast, Lazzeri amassed seven home runs in four successive games to set a Major League record.
June 6 – St. Louis Cardinals second basemanStu Martin ties a major league record with eleven assists in the first game of a doubleheader with the New York Giants.
July 18 – The Chicago White Sox and Philadelphia Athletics set an American League record for the most combined runs scored by two teams in Chicago's 21–14 victory. ChiSox outfielderRip Radcliff ties an AL record with six hits in seven at-bats.
October 2 – A seven run third inning, high lighted by Tony Lazzeri's grand slam, carries the Yankees to a 18–4 victory in game two of the World Series.
October 3 – Frankie Crosetti's eighth inning RBI single carries the Yankees to a 2–1 victory over the Giants in game three of the World Series.
October 4 – The Yankees jump to an early 4–0 lead against Carl Hubbell, and win game four of the World Series, 5–2.
October 5 – Jo-Jo Moore leads off the tenth with a double, and comes around to score, as the New York Giants take game five of the World Series, 5–4.
October 6 – The New York Yankees defeat the New York Giants, 13–5, in Game 6 of the World Series to win their fifth World Championship title, four games to two. During the six games, the Yankees score 43 runs and collect 65 hits.
December 10 – In a three team trade, the Washington Senators send Earl Whitehill to the Cleveland Indians, Indians sent Thornton Lee to the Chicago White Sox, and the White Sox send Jack Salveson to the Senators.
March 25 – Art Hagan, 73, Pitcher for two season from 1883 through 1884.
June 16 – Billy Shindle, 75, third baseman for the Detroit Wolverines, Baltimore Orioles, Philadelphia Athletics & Phillies, and Brooklyn Bridegrooms from 1886–98, and one of the first sluggers in the deadball era
June 18 – Al Nichols, 84, third baseman from 1875–1877. Banned for life after 1877 season with three other teammates for throwings games.
July 18 – Carl Stimson, 42, pitcher for the 1923 Boston Red Sox
September 9 - William Betts, Umpire in the National League and American League
October 8 – Red Ames, 54, pitcher for the New York Giants, Cincinnati Reds, St. Louis Cardinals and Philadelphia Phillies from 1903–19, and recorded 183 wins with a 2.63 ERA
October 27 – Dave Black, 44, pitcher for the Chicago ChiFeds/Whales, Baltimore Terrapins and Boston Red Sox
October 31 – Deacon McGuire, 72, catcher for several teams over 26 seasons who set records with 1611 games, 1858 assists and 9291 chances at his position; batted .300 five times and was first catcher to hit 300 doubles; later a coach and manager
November 9 – Bill Stellberger, 71, pitched one game for the 1885 Providence Grays.
December 11 – Myron Grimshaw, 61, right fielder for the Boston Americans from 1905 through 1907
December 26 – Bill Clymer, 63, shortstop for three games during the 1891 season.
December 31 – Doc Casey, 66, third baseman for the Washington Senators, Brooklyn Superbas, Detroit Tigers and Chicago Cubs between 1898 and 1907