BHFF

BHFF
Systematic (IUPAC) name
	5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	123557-91-5
ATC code	?
PubChem	CID 4332683
ChemSpider	3537035
Chemical data
Formula	C17H21F3O3
Mol. mass	330.341 g/mol
	SMILES FC(F)(F)C2(O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1OC2=O;
	InChI InChI=1S/C17H21F3O3/c1-14(2,3)9-7-10(15(4,5)6)12-11(8-9)16(22,13(21)23-12)17(18,19)20/h7-8,22H,1-6H3 ; Key:RVNOANDLZIIFHB-UHFFFAOYSA-N ;
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BHFF is a compound used in scientific research which acts as a positive allosteric modulator at the GABA_B receptor. It has anxiolytic effects in animal studies, and good oral bioavailability.^[1]

References [edit]

^ Malherbe, P; Masciadri, R; Norcross, RD; Knoflach, F; Kratzeisen, C; Zenner, MT; Kolb, Y; Marcuz, A et al. (2008). "Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors". British Journal of Pharmacology 154 (4): 797–811. doi:10.1038/bjp.2008.135. PMC 2439845. PMID 18536733. |displayauthors= suggested (help)

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