The effect of iomazenil of reducing levels of GABA in the brain was used by researchers to exacerbate symptoms in patients with schizophrenia in a laboratory study, supporting the theory that a GABA deficiency underlies that disease.
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^Ahn, Kyungheup; Gil R, Seibyl J, Sewell RA, D'Souza DC (February 2011). "Probing GABA receptor function in schizophrenia with iomazenil". Neuropsychopharmacology (Nature Publishing Group) 36 (3): 677–83. doi:10.1038/npp.2010.198. PMC3055690. PMID21068719.