Loreclezole

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Loreclezole
Loreclezole.svg
Systematic (IUPAC) name
1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)vinyl]-1H-1,2,4-triazole
Clinical data
Legal status
?
Identifiers
CAS number 117857-45-1 YesY
ATC code None
PubChem CID 3034012
ChemSpider 2298566 YesY
UNII 6DJ32STZ5W YesY
KEGG D04780 YesY
Chemical data
Formula C10H6Cl3N3 
Mol. mass 274.534 g/mol
 YesY (what is this?)  (verify)

Loreclezole is a sedative and an anticonvulsant which acts as a GABA agonist. It binds allosterically to the GABAA receptor.[1] The binding site of loreclezole has been shown experimentally to be shared by valerenic acid, an extract of the root of the valerian plant.[2]

References[edit]

  1. ^ Wingrove, P. B.; Wafford, K. A.; Bain, C.; Whiting, P. J. (1994). "The modulatory action of loreclezole at the gamma-aminobutyric acid type a receptor is determined by a single amino acid in the beta 2 and beta 3 subunit". Proceedings of the National Academy of Sciences of the United States of America 91 (10): 4569–4573. doi:10.1073/pnas.91.10.4569. PMC 43827. PMID 8183949.  edit
  2. ^ Khom, S.; Baburin, I.; Timin, E.; Hohaus, A.; Trauner, G.; Kopp, B.; Hering, S. (2007). "Valerenic acid potentiates and inhibits GABAA receptors: Molecular mechanism and subunit specificity". Neuropharmacology 53 (1): 178–187. doi:10.1016/j.neuropharm.2007.04.018. PMID 17585957.  edit