|Traded as||NASDAQ: BIIB
S&P 500 Component
|Founded||1978 (from merger)|
|Headquarters||Cambridge, Massachusetts, U.S.|
|Stelios Papadopoulos, Chairman, George A. Scangos, CEO|
|Products||Alprolix, Avonex, Eloctate, Fampyra, Gazyva*, Plegridy, Rituxan*, Tecfidera, Tysabri|
|Revenue||US$ 9.703 billion (2014) |
|US$ 3.972 billion (2014)|
|US$ 2.941 billion (2014)|
|Total assets||US$ 14.31 billion (2014)|
|Total equity||US$ 10.80 billion (2014)|
Number of employees
|7,550 (December 2014)|
Biogen is a global biotechnology company based in Cambridge, Massachusetts, specializing in the discovery, development, and delivery of therapies for the treatment of neurodegenerative, hematologic, and autoimmune diseases to patients worldwide.
Biogen was founded in 1978 in Geneva by several prominent biologists, including Sir Kenneth Murray of the University of Edinburgh, Phillip Sharp of the Massachusetts Institute of Technology, Walter Gilbert of Harvard (who served as CEO during the start-up phase) and Charles Weissmann, University of Zurich (who contributed the first product interferon alpha). Gilbert and Sharp were subsequently honored with Nobel Prizes: Gilbert was recognized in 1980 with the Nobel Prize in Chemistry for his work in understanding DNA sequencing, while Sharp received the Nobel Prize in Physiology or Medicine in 1993 for his discovery of split genes.
In 2003, Biogen merged with San Diego, California-based IDEC Pharmaceuticals (formed in 1986 by biotech pioneers Ivor Royston and Howard Birndorf) and adopted the name Biogen Idec. After the merge, Biogen Idec became the 3rd largest Biotechnology company in the world.  Following shifts in research core areas, the company has since shortened its name, reverting to simply Biogen. The intention of this change was to not only acknowledge their heritage but also create a new image to reflect their new reality.
In January 2015 the company announced it will acquire Convergence Pharmaceuticals for up to $675 million, with the acquisition aiming to accelerate the development of Convergence's pipeline, in-particular CNV1014802 – a Phase II small molecule sodium channel blocking candidate.
Biogen is managed by an executive group composed of ten officers:
- George A. Scangos, Ph.D., Chief Executive Officer and Member, Board of Directors
- Susan H. Alexander, Executive Vice President, General Counsel and Corporate Secretary
- Spyros Artavanis-Tsakonas, Ph.D., Chief Scientific Officer
- Paul J. Clancy, Executive Vice President and Chief Financial Officer
- John G. Cox, Executive Vice President of Pharmaceutical Operations & Technology
- Kenneth DiPietro, Executive Vice President of Human Resources
- Steven H. Holtzman, Executive Vice President of Corporate Development
- Tony Kingsley, Executive Vice President of Global Commercial Operations
- Adam Koppel, M.D., Ph.D., Chief Strategy Office and Senior Vice President of Commercial Assessment and Disease Strategy
- Alfred W. Sandrock, Jr., M.D., Ph.D., Chief Medical Officer and Group Senior Vice President of Development Sciences
- Douglas E. Williams, Ph.D., Executive Vice President, Research and Development
As is customary for a publicly traded company, Biogen is also overseen by a board of directors. The Executive Chairman and Chief Executive Officer both hold positions on the board of directors. The directors are Stelios Papadopoulos (chairman), George A. Scangos Ph.D. (CEO), Alexander J. Denner, Ph.D., Caroline Dorsa, Nancy L. Leaming, Richard C. Mulligan, Robert W. Pangia, Brian S. Posner, Eric K. Rowinsky, M.D., The Honorable Lynn Schenk, and Stephen A. Sherwin, M.D.
|Therapy||Indication (In United States unless otherwise noted)||Year Approved (US)||Year Approved (EU)||Additional Information|
|ALPROLIX™ [Coagulation Factor IX (Recombinant), Fc Fusion Protein]||Control and prevention of bleeding episodes, perioperative management and routine prophylaxis in adults and children with hemophilia B||2014||Also approved in Canada and Australia.
Biogen and Swedish Orphan Biovitrum (Sobi) are collaborators in the development and commercialization of ALPROLIX. 
|AVONEX® (interferon beta-1a)||Relapsing forms of multiple sclerosis||1996||1997||Includes the AVONEX PEN auto-injector and the AVOSTARTGRIP titration kit approved in the U.S. in 2012.|
|ELOCTATE™ [Antihemophilic Factor (Recombinant), Fc Fusion Protein]||Control and prevention of bleeding episodes, perioperative (surgical) management and routine prophylaxis in adults and children with hemophilia A||2014||Biogen and Swedish Orphan Biovitrum (Sobi) are collaborators in the development and commercialization of ELOCTATE.|
|FAMPYRA® (prolonged-release fampridine tablets)||Multiple sclerosis (Walking ability)||2010||2011||Marketed by Biogen in markets outside of the United Sates.
Commercialized in the United States as AMPYRA (dalfampridine) Extended Release Tablets, by Acorda Therapeutics.
|FUMADERM™ (fumaric acid esters)||Psoriasis||1994 (Germany only)||Approved in Germany.
Acquired in acquisition of Fumapharm AG in 2006.
|GAZYVA® (obinutuzumab)||Chronic lymphocytic leukemia||2013||The first medicine approved with the FDA’s Breakthrough Therapy Designation and is also currently in Phase 3 trials for NHL and diffuse large B-cell lymphoma.
Currently commercialized in the United States by Genentech, a wholly owned subsidiary of Roche.
|PLEGRIDY™ (peginterferon beta-1a)||Relapsing forms of multiple sclerosis||2014||2014|
|RITUXAN® (rituximab)||Non-Hodgkin's Lymphoma (NHL)
Anti-TNF Refractory Rheumatoid Arthritis
|1998 (as MabThera)||The first monoclonal antibody for cancer developed by IDEC, prior to merging with Biogen.
Currently commercialized by Roche and its subsidiary, Genentech.
|TECFIDERA® (dimethyl fumarate)||Relapsing forms of multiple sclerosis||2013||2014|
|TYSABRI® (natalizumab)||Relapsing-remitting multiple sclerosis||2004 Re-introduced in 2006||2006||Full rights purchased from partner Elan in 2013.|
Biogen has focused its R&D efforts on the discovery and development of treatments for patients with high unmet medical needs in the areas of neurology, hematology and immunology.
Investigational MS medicines:
- Daclizumab High-Yield Process (DAC HYP): is being developed as a potential once-monthly subcutaneous injection in the treatment of relapsing-remitting multiple sclerosis (RRMS). DAC HYP is being developed in collaboration with Abbvie, Inc. In June 2014, the companies announced positive top-line results from the Phase III DECIDE clinical trial, where DAC HYP demonstrated superiority over interferon beta-1a in annualized relapse rate.
- Anti-LINGO-1 (BIIB033): is the first candidate being investigated for its potential to remylinate and repair neurons damaged by MS, currently in Phase 2 trials.
Biogen has several candidates in Phase 1 and 2 clinical trials in neurodegenerative and immunological diseases including MS, Alzheimer’s disease, neuropathic pain, spinal muscular atrophy and lupus nephritis:
- Phase 2a: anti-LINGO-1 molecule in acute optic neuritis
- Phase 2b: anti-TWEAK monoclonal antibody in lupus nephritis
- Phase 2a: STX-100 in patients with idiopathic pulmonary fibrosis
- Phase 2: neublastin for neuropathic pain in 2013
- Phase 2: ISIS-SMNRx for spinal muscular atrophy in infants and children in collaboration with Isis Pharmaceuticals
- Phase 1b: BIIB037, Biogen’s first clinical study in Alzheimer’s disease
Biogen also has several development agreements in place with Isis Pharmaceuticals to collaborate to leverage antisense technology in advancing the treatment of neurological disorders.
In February 2012, Biogen formalized a joint venture with Samsung, creating Samsung Bioepis. This joint venture brings Biogen’s expertise and capabilities in protein engineering, cell line development, and recombinant biologics manufacturing to position the joint venture so Biogen can participate in the emerging market for biosimilars.
In early 2014, Biogen entered into an agreement with Eisai, Inc., to jointly develop and commercialize two of their candidates for Alzheimer’s disease, which have the potential to reduce Aβ plaques that form in the brains of patients, as well as to slow the formation of new plaques, potentially improving symptoms and suppressing disease progression.
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