|Systematic (IUPAC) name|
|Pregnancy cat.||B2 (AU)|
|Legal status||Pharmacy Only (S2) (AU) GSL (UK)|
|Routes||Oral, rectal, intravenous|
|Excretion||Renal (50%) and fecal|
|Mol. mass||360.467 g/mol|
|(what is this?)|
Butylscopolamine — also known as scopolamine butylbromide, butylhyoscine and hyoscine butylbromide — is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic. It is a quaternary ammonium compound and a semisynthetic derivative of scopolamine.
Butylscopolamine is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is also effective at preventing bladder spasms. It is not an analgesic in the normal sense, since it doesn't 'mask' or 'cover over' the pain, but rather works to prevent painful cramps and spasms from occurring in the first place. The attachment of the butyl-bromide moiety effectively prevents the movement of this drug across the blood–brain barrier, effectively minimising undesirable CNS side-effects associated with scopolamine/hyoscine.
It is marketed under the trade name Buscopan. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Hyoscine butylbromide is effective in significantly reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate.
Butylscopolamine is not centrally active and has a low incidence of abuse.
- Murakami, M.; Tomiyama, Y.; Hayakawa, K.; Akahane, M.; Ajisawa, Y.; Park, Y. C.; Ohnishi, N.; Sugiyama, T.; Kurita, T. (2000). "Effects of β-Adrenergic Stimulation on the Acutely Obstructed Ureter in Dogs" (pdf). Journal of Pharmacology and Experimental Therapeutics 292 (1): 67–75. PMID 10604932.
- "WHO Model List of EssentialMedicines". World Health Organization. October 2013. Retrieved 22 April 2014.
- Tytgat, G. N. (2007). "Hyoscine Butylbromide: A Review of its Use in the Treatment of Abdominal Cramping and Pain". Drugs 67 (9): 1343–1357. doi:10.2165/00003495-200767090-00007. PMID 17547475.
- Samuels, L. A.; Christie, L.; Roberts-Gittens, B.; Fletcher, H.; Frederick, J. (2007). "The effect of hyoscine butylbromide on the first stage of labour in term pregnancies". BJOG 114 (12): 1542–1546. doi:10.1111/j.1471-0528.2007.01497.x. PMID 17903230.
- "Buscopan / Buscapina". Boehringer Ingelheim.