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Calcium gluconate

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Calcium gluconate
Clinical data
PronunciationKAL-see-um GLUE-koe-nate
AHFS/Drugs.comMonograph
License data
Routes of
administration		By mouth, intravenous, topical
ATC code
Identifiers
  • calcium (2R,3S,4R,5R)- 2,3,4,5,6-pentahydroxyhexanoate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E numberE578 (acidity regulators, ...) Edit this at Wikidata
CompTox Dashboard (EPA)
ECHA InfoCard100.005.524 Edit this at Wikidata
Chemical and physical data
FormulaC12H22CaO14
Molar mass430.372 g·mol−1
3D model (JSmol)
Melting point120 °C (248 °F) (decomposes)
Solubility in waterslowly soluble
  • [Ca+2].[O-]C(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[O-]C(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
  • InChI=1S/2C6H12O7.Ca/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
  • Key:NEEHYRZPVYRGPP-IYEMJOQQSA-L

Calcium gluconate is the calcium salt of gluconic acid and is used as a mineral supplement and medication.[1] As a medication it is used by injection into a vein to treat low blood calcium, high blood potassium, and magnesium toxicity.[1][2] Supplementation is generally only required when there is not enough calcium in the diet.[3] Supplementation may be done to treat or prevent osteoporosis or rickets.[1] It can also be taken by mouth but is not recommended for injection into a muscle.[1]

Side effects when injected include slow heart rate, pain at the site of injection, and low blood pressure.[3] When taken by mouth side effects may include constipation and nausea.[1] Blood calcium levels should be measured when used and extra care should be taken in those with a history of kidney stones.[3] At normal doses, use is regarded as safe in pregnancy and breastfeeding.[1][4] Calcium gluconate is made by mixing gluconic acid with calcium carbonate or calcium hydroxide.[5]

Calcium gluconate came into medical use in the 1920s.[6] It is on the World Health Organization's List of Essential Medicines.[7] Calcium gluconate is available as a generic medication.[2][8]

It is closely related to calcium borogluconate, which is commonly used in veterinary medicine owning to its higher solubility. [9] It is used for intravenous administration of calcium, notably in ruminants.[10]

Production

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Calcium gluconate is produced commercially through three main methods. These three methods are: chemical oxidation of glucose with a hypochlorite solution, electrolytic oxidation of a glucose solution containing a known value of bromide, and a fermentation process where specific microorganisms are grown in a medium containing glucose and various other ingredients.[11]

Medical uses

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Low blood calcium

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10% calcium gluconate solution (given intravenously) is the form of calcium most widely used in the treatment of low blood calcium. This form of calcium is not as well absorbed as calcium lactate,[12] and it only contains 0.93% (93 mg/dL) calcium ion (defined by 1 g weight solute in 100 mL of solution to make 1% solution w/v). Therefore, if the hypocalcemia is acute and severe, calcium chloride is given instead.

High blood potassium

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Calcium gluconate is used as a cardioprotective agent in people with high blood potassium levels, with one alternative being the use of calcium chloride.[13] It is recommended when the potassium levels are high (>6.5 mmol/L) or when the electrocardiogram (ECG) shows changes due to high blood potassium.[2]

Though it does not have an effect on potassium levels in the blood, it reduces the excitability of cardiomyocytes, thereby lowering the likelihood of cardiac arrhythmias.[14]

Magnesium sulfate overdose

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It is also used to counteract an overdose of Epsom salts magnesium sulfate,[15] which is often administered to pregnant women in order to prophylactically prevent seizures (as in a patient experiencing preeclampsia). Magnesium sulfate is no longer given to pregnant women who are experiencing premature labor in order to slow or stop their contractions (other tocolytics are now used instead due to better efficacy and side effect profiles).[citation needed] Excess magnesium sulfate results in magnesium sulfate toxicity, which results in both respiratory depression and a loss of deep tendon reflexes (hyporeflexia).

Hydrofluoric acid burns

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Main article: Hydrofluoric acid burn
A tube of calcium gluconate gel

Gel preparations of calcium gluconate are used to treat hydrofluoric acid burns.[16][17] The calcium gluconate reacts with hydrofluoric acid to form insoluble, non-toxic calcium fluoride. In addition to a 2.5% calcium gluconate gel being applied directly to the chemical burn, the person may also receive calcium gluconate supplements because the fluoride ion precipitates serum calcium, causing hypocalcemia.[18]

Cardiac arrest

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While intravenous calcium has been used in cardiac arrest, its general use is not recommended.[1] Cases of cardiac arrest in which it is still recommended include high blood potassium, low blood calcium such as may occur following blood transfusions, and calcium channel blocker overdose.[1] There is the potential that general use could worsen outcomes.[1] If calcium is used, calcium chloride is generally the recommended form.[1]

Side effects

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Calcium gluconate side effects include nausea, constipation, and upset stomach. Rapid intravenous injections of calcium gluconate may cause hypercalcemia, which can result in vasodilation, cardiac arrhythmias, decreased blood pressure, and bradycardia. Extravasation of calcium gluconate can lead to cellulitis. Intramuscular injections may lead to local necrosis and abscess formation.[19]

It is also reported that this form of calcium increases renal plasma flow, urine production, sodium excretion,[20][21] glomerular filtration rate,[22] and prostaglandin E2 and F1-alpha levels.[23]

Society and culture

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  • Shortages of medical calcium gluconate were reported in November 2012 and November 2015 in the United States.[13][24]
  • Historically, intravenous calcium gluconate was used as an antidote for black widow spider envenomation, often in conjunction with muscle relaxants.[25] This therapy, however, has since been shown to be ineffective.[26][27]

See also

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References

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  1. ^ a b c d e f g h i j "Calcium Salts". The American Society of Health-System Pharmacists. Archived from the original on 18 January 2017. Retrieved 8 January 2017.
  2. ^ a b c British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. pp. 680, 694. ISBN 9780857111562.
  3. ^ a b c World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 497. hdl:10665/44053. ISBN 9789241547659.
  4. ^ "Calcium gluconate Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 18 January 2017. Retrieved 15 January 2017.
  5. ^ Bhattacharya S (2014). Conventional and Advanced Food Processing Technologies. John Wiley & Sons. p. 391. ISBN 9781118406304. Archived from the original on 18 September 2017.
  6. ^ Tegethoff FW (2012). Calcium Carbonate: From the Cretaceous Period into the 21st Century. Birkhäuser. p. 308. ISBN 9783034882453. Archived from the original on 18 September 2017.
  7. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  8. ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
  9. ^ Macpherson HT, Stewart J (January 1938). "Investigations on the nature of calcium borogluconate". Biochem Journal. 32 (1): 76–78. doi:10.1042/bj0320076. PMC 1263995. PMID 16746604.
  10. ^ Constable, P (November 2003). "Fluid and electrolyte therapy in ruminants". Veterinary Clinics of North America: Food Animal Practice. 19 (3): 557–597. doi:10.1016/S0749-0720(03)00054-9. PMID 14608802.
  11. ^ Shindia AA, El-Sherbeny GA, El-Esawy AE, Sheriff YM (March 2006). "Production of gluconic Acid by some local fungi". Mycobiology. 34 (1): 22–29. doi:10.4489/MYCO.2006.34.1.022. PMC 3769535. PMID 24039465.
  12. ^ Spencer H, Scheck J, Lewin I, Samachson J (July 1966). "Comparative absorption of calcium from calcium gluconate and calcium lactate in man". The Journal of Nutrition. 89 (3): 283–292. doi:10.1093/jn/89.3.283. PMID 4288031.
  13. ^ a b Miller D, Faine B (December 2013). "The Calcium Quandary". Emergency Physicians Monthly. Archived from the original on 21 November 2015. Retrieved 20 November 2015.
  14. ^ Parham WA, Mehdirad AA, Biermann KM, Fredman CS (2006). "Hyperkalemia revisited". Texas Heart Institute Journal. 33 (1): 40–47. PMC 1413606. PMID 16572868.
  15. ^ Omu AE, Al-Harmi J, Vedi HL, Mlechkova L, Sayed AF, Al-Ragum NS (2008). "Magnesium sulphate therapy in women with pre-eclampsia and eclampsia in Kuwait". Medical Principles and Practice. 17 (3): 227–232. doi:10.1159/000117797. PMID 18408392. S2CID 3079436.
  16. ^ el Saadi MS, Hall AH, Hall PK, Riggs BS, Augenstein WL, Rumack BH (June 1989). "Hydrofluoric acid dermal exposure". Veterinary and Human Toxicology. 31 (3): 243–247. PMID 2741315.
  17. ^ Roblin I, Urban M, Flicoteau D, Martin C, Pradeau D (2006). "Topical treatment of experimental hydrofluoric acid skin burns by 2.5% calcium gluconate". Journal of Burn Care & Research. 27 (6): 889–894. doi:10.1097/01.BCR.0000245767.54278.09. PMID 17091088. S2CID 3691306.
  18. ^ Urden LD (2014). Critical Care Nursing : Diagnosis and Management (7th ed.). St. Louis, Mo.: Elsevier/Mosby. p. 936. ISBN 978-0-323-09178-7. OCLC 830669119.
  19. ^ Lam YM, Tse HF, Lau CP (April 2001). "Continuous calcium chloride infusion for massive nifedipine overdose". Chest. 119 (4): 1280–1282. doi:10.1378/chest.119.4.1280. PMID 11296202.
  20. ^ Ruilope LM, Oliet A, Alcázar JM, Hernández E, Andrés A, Rodicio JL, et al. (December 1989). "Characterization of the renal effects of an intravenous calcium gluconate infusion in normotensive volunteers". Journal of Hypertension Supplement. 7 (6): S170–S171. doi:10.1097/00004872-198900076-00081. PMID 2632708.
  21. ^ Bernardi M, Di Marco C, Trevisani F, Fornalè L, Andreone P, Cursaro C, et al. (July 1993). "Renal sodium retention during upright posture in preascitic cirrhosis". Gastroenterology. 105 (1): 188–193. doi:10.1016/0016-5085(93)90025-8. PMID 8514034.
  22. ^ Wong F, Massie D, Colman J, Dudley F (March 1993). "Glomerular hyperfiltration in patients with well-compensated alcoholic cirrhosis". Gastroenterology. 104 (3): 884–889. doi:10.1016/0016-5085(93)91026-e. PMID 8440439.
  23. ^ Lahera V, Fiksen-Olsen MJ, Romero JC (February 1990). "Stimulation of renin release by intrarenal calcium infusion". Hypertension. 15 (2 Suppl): I149–I152. doi:10.1161/01.hyp.15.2_suppl.i149. PMID 2404858.
  24. ^ "FDA Drug Shortages". www.accessdata.fda.gov. Archived from the original on 18 September 2017. Retrieved 21 November 2015.
  25. ^ Pestana C (July 2015). Dr. Pestana's Surgery Notes: Top 180 Vignettes for the Surgical Wards. Simon and Schuster. ISBN 978-1-5062-0201-3.
  26. ^ Offerman SR, Daubert GP, Clark RF (2011). "The treatment of black widow spider envenomation with antivenin latrodectus mactans: a case series". The Permanente Journal. 15 (3): 76–81. doi:10.7812/tpp/10-136. PMC 3200105. PMID 22058673.
  27. ^ Clark RF, Wethern-Kestner S, Vance MV, Gerkin R (July 1992). "Clinical presentation and treatment of black widow spider envenomation: a review of 163 cases". Annals of Emergency Medicine. 21 (7): 782–787. doi:10.1016/S0196-0644(05)81021-2. PMID 1351707.
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