Eucalyptus oil is the generic name for distilled oil from the leaf of Eucalyptus, a genus of the plant family Myrtaceae native to Australia and cultivated worldwide. Eucalyptus oil has a history of wide application, as a pharmaceutical, antiseptic, repellent, flavouring, fragrance and industrial uses. The leaves of selected Eucalyptus species are steam distilled to extract eucalyptus oil.
Types and production 
Eucalyptus oils in the trade are categorized into three broad types according to their composition and main end-use: medicinal, perfumery and industrial. The most prevalent is the standard cineole-based "oil of eucalyptus", a colourless mobile liquid (yellow with age) with a penetrating, camphoraceous, woody-sweet scent.
China produces about 75% of the world trade, but most of this is derived from camphor oil fractions rather than being true eucalyptus oil. Significant producers of true eucalyptus oil include South Africa, Portugal, Spain, Brazil, Australia, Chile and Swaziland.
Global production is dominated by Eucalyptus globulus. However, Eucalyptus kochii and Eucalyptus polybractea have the highest cineole content, ranging from 80-95%. The British Pharmacopoeia states that the oil must have a minimum cineole content of 70% if it is pharmaceutical grade. Rectification is used to bring lower grade oils up to the high cineole standard required. Global annual production of eucalyptus oil is estimated at 3,000 tonnes. The eucalyptus genus also produces non-cineole oils, including piperitone, phellandrene, citral, methyl cinnamate and geranyl acetate.
Medicinal and antiseptic 
The cineole-based oil is used as component in pharmaceutical preparations to relieve the symptoms of influenza and colds, in products like cough sweets, lozenges, ointments and inhalants. Eucalyptus oil has antibacterial effects on pathogenic bacteria in the respiratory tract. Inhaled eucalyptus oil vapor is a decongestant and treatment for bronchitis. Cineole controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition. Eucalyptus oil also stimulates immune system response by effects on the phagocytic ability of human monocyte derived macrophages.
Repellent and biopesticide 
Eucalyptus oil is used in flavouring. Cineole-based eucalyptus oil is used as a flavouring at low levels (0.002%) in various products, including baked goods, confectionery, meat products and beverages. Eucalyptus oil has antimicrobial activity against a broad range of foodborne human pathogens and food spoilage microorganisms. Non-cineole peppermint gum, strawberry gum and lemon ironbark are also used as flavouring.
Research shows that cineole-based eucalyptus oil (5% of mixture) prevents the separation problem with ethanol and petrol fuel blends. Eucalyptus oil also has a respectable octane rating and can be used as a fuel in its own right. However, production costs are currently too high for the oil to be economically viable as a fuel.
Safety and toxicity 
If consumed internally at low dosage as a flavouring component or in pharmaceutical products at the recommended rate, cineole-based 'oil of eucalyptus' is safe for adults. However, systemic toxicity can result from ingestion or topical application at higher than recommended doses.
The probable lethal dose of pure eucalyptus oil for an adult is in the range of 0.05 mL to 0.5 mL/per kg of body weight. Because of their high body surface area to mass ratio, children are more vulnerable to poisons absorbed transdermally. Severe poisoning has occurred in children after ingestion of 4 mL to 5 mL of eucalyptus oil.
Dennis Considen and John White, surgeons on the First Fleet, distilled eucalyptus oil from Eucalyptus piperita found growing on the shores of Port Jackson in 1788 to treat convicts and marines. Eucalyptus oil was subsequently extracted by early colonists, but was not commercially exploited for some time.
Baron Ferdinand von Mueller, Victorian botanist, promoted the qualities of Eucalyptus as a disinfectant in "fever districts", and also encouraged Joseph Bosisto, a Melbourne pharmacist, to investigate the commercial potential of the oil. Bosisto started the commercial eucalyptus oil industry in 1852 near Dandenong, Victoria, Australia, when he set up a distillation plant and extracted the essential oil from the cineole chemotype of Eucalyptus radiata. This resulted in the cineole chemotype becoming the generic 'oil of eucalyptus', and "Bosisto's Eucalyptus Oil" still survives as a brand.
French chemist, F.S. Cloez, identified and ascribed the name eucalyptol — also known as cineole — to the dominant portion of E. globulus oil. By the 1870s oil from Eucalyptus globulus, Tasmanian blue gum, was being exported worldwide and eventually dominated world trade, while other higher quality species were also being distilled to a lesser extent. Surgeons were using eucalyptus oil as an antiseptic during surgery by the 1880s.
The Australian eucalyptus oil industry peaked in the 1940s, the main area of production being the central goldfields region of Victoria, particularly Inglewood; then the global establishment of eucalyptus plantations for timber resulted in increased volumes of eucalyptus oil as a plantation by-product. By the 1950s the cost of producing eucalyptus oil in Australia had increased so much that it could not compete against cheaper Spanish and Portuguese oils (closer to European Market therefore less costs). Non-Australian sources now dominate commercial eucalyptus oil supply, although Australia continues to produce high grade oils, mainly from blue mallee (E. polybractea) stands.
Species utilised 
Commercial cineole-based eucalyptus oils are produced from several species of Eucalyptus:
- Eucalyptus cneorifolia
- Eucalyptus dives
- Eucalyptus dumosa
- Eucalyptus globulus
- Eucalyptus goniocalyx
- Eucalyptus horistes
- Eucalyptus kochii
- Eucalyptus leucoxylon
- Eucalyptus oleosa
- Eucalyptus polybractea
- Eucalyptus radiata
- Eucalyptus sideroxylon
- Eucalyptus smithii
- Eucalyptus tereticornis
- Eucalyptus viridis
Non-cineole oil producing species:
- Eucalyptus dives - phellandrene variant
- Eucalyptus dives - piperitone variant
- Eucalyptus elata - piperitone variant
- Eucalyptus macarthurii - geranyl acetate
- Eucalyptus olida - methyl cinnamate
- Eucalyptus radiata - phellandrene variant
- Eucalyptus staigeriana - citral, limonene
Compendial status 
See also 
- Essential oil
- Eucalypts, woody plants belonging to three closely related genera: Eucalyptus, Corymbia and Angophora
- Lawless, J., The Illustrated Encyclopedia of Essential Oils, Element Books 1995 ISBN 1-85230-661-0
- Ashurst, P.R., Food Flavorings, 1999
- Salari, M. H., Amine, G., Shirazi, M. H., Hafezi, R., and Mohammadypour, M. “Antibacterial effects of Eucalyptus globulus leaf extract on pathogenic bacteria isolated from specimens of patients with respiratory tract disorders.” Clin Microbiol.Infect. 2006;12(2):194–196.
- Lu XQ, Tang FD, Wang Y, Zhao T, Bian RL, Effect of Eucalyptus globulus oil on lipopolysaccharide-induced chronic bronchitis and mucin hypersecretion in rats, Zhongguo Zhong Yao Za Zhi, 2004 Feb;29(2):168–71.
- Juergens, U. et al., activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial, Respiratory Medicine, 2003, Vol. 97, Iss. 3, pp. 250–256. 
- Juergens, U., Engelen, T., Racké, K., Stöber, M., Gillissen, A., Vetter, H., Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes, Pulmonary Pharmacology & Therapeutics, 2004, Vol. 17, Iss. 5, pp. 281–287 
- Serafino, A., Vallebona, P.S., Andreola, F., Zonfrillo, M., Mercuri, L., Federici, M., Rasi, G., Garaci, E., and Pierimarchi, P., Stimulatory effect of Eucalyptus essential oil on innate cell-mediated immune response, BMC Immunol. 2008; 9: 17.
- Göbel, H., Schmidt, G., Soyka, D., Effect of peppermint and eucalyptus oil preparations on neurophysiological and experimental algesimetric headache parameters, Cephalalgia, Vol. 14, Iss. 3, pp. 228–234, 19 January 2002.
- Hong, C-Z., Shellock, F.G., Effects of a topically applied counterirritant (Eucalyptmint) on cutaneous blood flow and on skin and muscle temperatures: a placebo-controlled study, American Journal of Physical Medicine & Rehabilitation 70(1):29–33, February 1991.
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- Boland, D.J., Brophy, J.J., and A.P.N. House, Eucalyptus Leaf Oils, 1991, p. 8 ISBN 0-909605-69-6
- Darben T, Cominos L, Lee CT. Topical Eucalyptus Oil Poisoning. Australasian Journal of Dermatology, 1998, Vol.39, pp. 265–7.
- Hindle, R.C., Eucalyptus oil ingestion, New Zealand Medical Journal, 1994, pp. 185–186
- Allan, J., Poisoning by oil of eucalyptus, British Medical Journal, 1910 Vol.1, p. 569.
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- Low, T., Bush Medicine, A Pharmacopeia of Natural Remedies, Angus & Robertson, p. 85, 1990.
- Barr, A., Chapman, J., Smith, N., Beveridge, M., Traditional Bush Medicines, An Aboriginal Pharmacopoeia, Greenhouse Publications, pp. 116–117, 1988, ISBN 0 86436 167.
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- Boland, D.J., Brophy, J.J., and A.P.N. House, Eucalyptus Leaf Oils, 1991, p. 6 ISBN 0-909605-69-6
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- The British Pharmacopoeia Secretariat (2009). "Index, BP 2009". Retrieved 10 September 2009.
Further reading 
- Boland, D.J., Brophy, J.J., and A.P.N. House, Eucalyptus Leaf Oils, 1991, ISBN 0-909605-69-6
- FAO Corporate Document Repository, Flavours and fragrances of plant origin
- Toxicity Eucalyptus oil profile, Chemical Safety Information from Intergovernmental Organizations
- Eucalyptus oil (E. globulus Labillardiere, E. fructicetorum F. Von Mueller, E. smithii R.T. Baker) MedlinePlus, U.S. National Library of Medicine, U.S. National Institutes of Health evidence-based monograph prepared by the Natural Standard Research Collaboration