December 2, 1885|
|Died||February 25, 1950(aged 64)|
|Institutions||Johns Hopkins School of Medicine|
|Alma mater||Harvard University|
Treatment of pernicious anemia
|Notable awards||1934 Nobel Prize in Physiology or Medicine|
Not to be confused with American historian and judge George Richards Minot (judge) (1758–1802)
George Richards Minot (December 2, 1885 – February 25, 1950) was an American medical researcher who shared the 1934 Nobel Prize with George Hoyt Whipple and William P. Murphy for their pioneering work on pernicious anemia.
George Richards Minot was born in Boston, Massachusetts. He came from a medical family; his father was physician James Jackson Minot (1853–1938). One of his great-grandfathers was James Jackson (1777–1867), co-founder of Massachusetts General Hospital. He was namesake of his great-great-grandfather George Richards Minot (1758–1802). His mother was Elizabeth Whitney. His father's cousin was anatomist Charles Sedgwick Minot (1852–1914).
He completed his A.B. in 1908 and his M.D. in 1912 from Harvard University. Between 1914 to 1915, George Minot was appointed Assistant in Medicine at the Johns Hopkins University in Baltimore, MD. In 1915, he was appointed Assistant in Medicine at the Harvard Medical School. Minot won the 1934 Nobel Prize in Physiology or Medicine with William P. Murphy and George H. Whipple for their work in the study of anemia. George Minot, working with William Murphy, described an effective treatment for pernicious anemia with liver (which is high in vitamin B12, later identified as the critical compound in the treatment.)
Minot had diabetes mellitus, which was a uniformly fatal disease during the early part of his life. Dr. William Castle observed that Banting and Best's 1921 discovery of insulin not only transformed diabetes treatment, but, by keeping Minot alive, was therefore also responsible for the discovery of a cure for pernicious anemia.
Minot began suffering from complications associated with diabetes in 1947, suffering a serious stroke the same year. He died on February 25, 1950. He was a Unitarian. His home in Brookline, Massachusetts, was designated a National Historic Landmark in recognition for his work.
Minot and his wife Marian (1890-1979) had two daughters and a son.
- "Obituary". New England Journal of Medicine 242 (14): 565–565. April 6, 1950. doi:10.1056/NEJM195004062421414.
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- "Sedgwick Family Papers 1717–1946 Guide to the Collection". Massachusetts Historical Society. Retrieved February 4, 2011.
- Castle, W B (1962). "The Gordon Wilson Lecture: A century of curiosity about pernicious anemia". Trans Am Clin Climatol Assoc 73: 54–80. PMC 2249021. PMID 21408623.
- "NHL nomination for George R. Minot House" (PDF). National Park Service. Retrieved 2014-05-20.
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- Rackemann, F M (1956). The Inquisitive Physician: The Life and Times of George Richards Minot, A.B, M.D., D.Sc. Cambridge, MA: Harvard University Press.
- Minot, G R; Murphy W P (2001). "Treatment of pernicious anemia by a special diet. 1926". The Yale journal of biology and medicine (United States) 74 (5): 341–53. ISSN 0044-0086. PMC 2588744. PMID 11769340.
- Raju, T N (January 1999). "The Nobel chronicles. 1934: George Hoyt Whipple (1878–1976); George Richard Minot (1885–1950); William Perry Murphy (1892–1987)". The Lancet (England) 353 (9148): 247. doi:10.1016/S0140-6736(05)77266-4. ISSN 0140-6736. PMID 9923916.
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- Halperin, E C (November 1991). "A groundless hypothesis, megaloblastic madness, and the founding of Duke University". Med. Hypotheses (England) 36 (3): 200–3. doi:10.1016/0306-9877(91)90130-Q. ISSN 0306-9877. PMID 1787810.
- Crosby, W H (1983). "Landmark perspective. Pernicious anemia". Journal of the American Medical Association 250 (24): 3336–8. doi:10.1001/jama.250.24.3336. ISSN 0098-7484. PMID 6358571.
- Minot, G R; Murphy W P (1983). "Landmark article (JAMA 1926). Treatment of pernicious anemia by a special diet. By George R. Minot and William P. Murphy". Journal of the American Medical Association 250 (24): 3328–35. doi:10.1001/jama.250.24.3328. ISSN 0098-7484. PMID 6358569.
- Kass, L (December 1978). "William B. Castle and intrinsic factor". Ann. Intern. Med. (United States) 89 (6): 983–91. doi:10.7326/0003-4819-89-6-983. ISSN 0003-4819. PMID 363011.
- "Nutrition Classics. The Journal of the American Medical Association 87:470-6, 1926. Treatment of pernicious anemia by a special diet. George R. Minot and William P. Murphy". Nutr. Rev. 36 (2): 50–52. February 1978. ISSN 0029-6643. PMID 345160.
- Castle, W B (1974). "George Richards Minot". Biographical memoirs. National Academy of Sciences (U.S.) 45: 337–83. PMID 11615649.
- Sulek, K (April 1968). "[Nobel prize in 1934 for G.H. Whipple, G.R. Minot and W.P. Murphy for discovery of treatment of anemia with liver extracts]". Wiad. Lek. (Poland) 21 (7): 627–9. ISSN 0043-5147. PMID 4876155.
- Kenéz, J (December 1965). "[George Richards Minot and the conquest of pernicious anemia]". Medizinische Klinik (in German) (Germany) 60 (50): 2038–9. ISSN 0025-8458. PMID 5331154.
- Kenez, J (May 1965). "[Minot and Liver Therapy]". Orvosi hetilap (in Hungarian) (Hungary) 106: 945–7. ISSN 0030-6002. PMID 14298569.
- Nobel e-Museum: George R. Minot – Biography
- "Red-Blooded Doctors Cure Anemia"
- Pernicious Anemia, a Victory for Science
- George Minot — Biographical Memoirs of the National Academy of Sciences
- Profile at the Nobel Prize website