Jack W. Szostak
|Jack William Szostak|
Szostak at the 2010 Lindau Nobel Laureate Meeting
November 9, 1952 |
London, United Kingdom
|Institutions||Harvard Medical School
Howard Hughes Medical Institute
|Alma mater||McGill University
|Thesis||Specific binding of a synthetic oligonucleotide to the yeast iso-1 cytochrome c̲ mRNA and gene (1977)|
|Doctoral advisor||Ray Wu|
|Notable students||David Bartel, Jennifer Doudna, Terry Orr-Weaver, Andrew Murray, Rachel Green|
|Notable awards||Nobel Prize for Physiology or Medicine (2009)
Lasker Award (2006)
Jack William Szostak (born November 9, 1952) is a Canadian American biologist of Polish British descent and Professor of Genetics at Harvard Medical School and Alexander Rich Distinguished Investigator at Massachusetts General Hospital, Boston. He was awarded the 2009 Nobel Prize for Physiology or Medicine, along with Elizabeth Blackburn and Carol W. Greider, for the discovery of how chromosomes are protected by telomeres.
Szostak grew up in Montreal and Ottawa. Although Szostak does not speak Polish, he stated in an interview with Wprost weekly that he remembers his Polish roots. He attended Riverdale High School (Quebec) and graduated at the age of 15 with the scholars prize. He graduated with a B.Sc in cell biology from McGill University at the age of 19. In 1970, as an undergraduate, he participated in The Jackson Laboratory's Summer Student Program under the mentorship of Dr. Chen K. Chai. He completed his PhD in biochemistry at Cornell University (advisor Prof. Ray Wu) before moving to Harvard Medical School to start his own lab at the Sydney Farber Cancer Institute. He credits Ruth Sager for giving him his job there when he had little yet to show. In 1984 Howard Goodman lured him away to Massachusetts General Hospital and the Department of Molecular Biology. He was granted tenure and a full professorship at Harvard Medical School in 1988.
Szostak has made contributions to the field of genetics. He is credited with the construction of the world's first yeast artificial chromosome. That achievement helped scientists to map the location of genes in mammals and to develop techniques for manipulating genes. His achievements in this area are also instrumental to the Human Genome Project.
His discoveries have helped to clarify the events that lead to chromosomal recombination—the reshuffling of genes that occurs during meiosis—and the function of telomeres, the specialized DNA sequences at the tips of chromosomes.
In the early 90s his laboratory shifted its research direction and focused on studying RNA enzymes, which had been recently discovered by Cech and Altman. He developed the technique of in vitro evolution of RNA (also developed independently by Gerald Joyce) which enables the discovery of RNAs with desired functions through successive cycles of selection, amplification and mutation. He isolated the first aptamer (term he used for the first time). He isolated RNA enzymes with RNA ligase activity directly from random sequence (project of David Bartel).
Awards and honors
Szostak has received several awards and honors for his contributions. He is a member of the National Academy of Sciences, American Academy of Arts and Sciences and New York Academy of Sciences. He has received the following awards:
- United States National Academy of Sciences Award in Molecular Biology
- Hans Sigrist Prize, University of Bern, Switzerland
- Genetics Society of America Medal
- The 2006 Lasker Award
- The 2008 Dr H.P. Heineken Prize for Biochemistry and Biophysics
- The 2009 Nobel Prize for Physiology or Medicine (shared with Elizabeth Blackburn and Carol W. Greider)
- I want to get to know first steps of evolution - Interview with Jack Szostak (in Polish) "Moi pradziadowie wyemigrowali z Polski do USA. Ja urodziłem się w Londynie, a potem mieszkałem w Kanadzie. Niestety, nie mówię po polsku, ale chętnie przyznaje się do swoich polskich korzeni"( English translation: "My grandparents emigrated from Poland to the U.S.A. i was born in London, and then lived in Canada. Unfortunately, I do not speak Polish, but I eagerly confess to my Polish roots")
- Ray Wu, as remembered by a former student
- http://exploringorigins.org/ Exploringorigins.org
- "Blackburn, Greider, and Szostak share Nobel". Dolan DNA Learning Center. Retrieved 2009-10-05.
- "About Jack W. Szostak". The Howard Hughes Medical Institute. Retrieved 2007-11-02.
- "Jack W. Szostak at Harvard University". Harvard University. Retrieved 2007-11-02.
- "Curriculum Vitae of Jack W. Szostak". Massachusetts General Hospital. Retrieved 2007-11-02.
- Nobel Prize information
- Szostak Lab website
- DNA Ends: Just the Beginning Nobel Prize Lecture
- Jack Szostak's lecture: "The Origin of Life on Earth"