Integrin, beta 6

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Integrin, beta 6
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol ITGB6
External IDs OMIM147558 MGI96615 HomoloGene685 ChEMBL: 4876 GeneCards: ITGB6 Gene
RNA expression pattern
PBB GE ITGB6 208083 s at tn.png
PBB GE ITGB6 208084 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3694 16420
Ensembl ENSG00000115221 ENSMUSG00000026971
UniProt P18564 Q9Z0T9
RefSeq (mRNA) NM_000888 NM_001159564
RefSeq (protein) NP_000879 NP_001153036
Location (UCSC) Chr 2:
160.96 – 161.13 Mb
Chr 2:
60.6 – 60.72 Mb
PubMed search [1] [2]

Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene.[1][2][3]


Clinical effects[edit]

Mutations in ITGB6 cause amelogenesis imperfecta .[4]

Interactions[edit]

Integrin, beta 6 has been shown to interact with FHL2.[5]

References[edit]

  1. ^ Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, Eccles M, Leung E, Watson JD (February 1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173. 
  2. ^ Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D (April 1994). "Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor". J Biol Chem 269 (9): 6940–8. PMID 8120056. 
  3. ^ "Entrez Gene: ITGB6 integrin, beta 6". 
  4. ^ Wang, S. K.; Choi, M; Richardson, A. S.; Reid, B. M.; Lin, B. P.; Wang, S. J.; Kim, J. W.; Simmer, J. P.; Hu, J. C. (2014). "ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta". Human Molecular Genetics 23 (8): 2157–63. doi:10.1093/hmg/ddt611. PMC 3959820. PMID 24305999.  edit
  5. ^ Wixler, V; Geerts D; Laplantine E; Westhoff D; Smyth N; Aumailley M; Sonnenberg A; Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324. 

Further reading[edit]

External links[edit]