CEBPA

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CCAAT/enhancer binding protein (C/EBP), alpha
1nwq.png
PDB rendering based on 1nwq.[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CEBPA ; C/EBP-alpha; CEBP
External IDs OMIM116897 MGI99480 HomoloGene3211 GeneCards: CEBPA Gene
Orthologs
Species Human Mouse
Entrez 1050 12606
Ensembl ENSG00000245848 ENSMUSG00000034957
UniProt P49715 P53566
RefSeq (mRNA) NM_004364 NM_007678
RefSeq (protein) NP_004355 NP_031704
Location (UCSC) Chr 19:
33.79 – 33.79 Mb
Chr 7:
35.12 – 35.12 Mb
PubMed search [1] [2]

CCAAT/enhancer-binding protein alpha is a protein that in humans is encoded by the CEBPA gene.[2][3]

Function[edit]

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.[4]

Interactions[edit]

CEBPA has been shown to interact with Cyclin-dependent kinase 2[5] and Cyclin-dependent kinase 4.[5]

Clinical significance[edit]

It has been shown that mutation of CEBPA has been linked to good outcome in both adult and pediatric acute myeloid leukemia patients.[6]

See also[edit]

Ccaat-enhancer-binding proteins

References[edit]

  1. ^ Miller, M; Shuman, J. D.; Sebastian, T; Dauter, Z; Johnson, P. F. (2003). "Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha". Journal of Biological Chemistry 278 (17): 15178–84. doi:10.1074/jbc.M300417200. PMID 12578822.  edit
  2. ^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (July 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333. 
  3. ^ Cao Z, Umek RM, McKnight SL (October 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes Dev 5 (9): 1538–52. doi:10.1101/gad.5.9.1538. PMID 1840554. 
  4. ^ "Entrez Gene: CEBPA CCAAT/enhancer binding protein (C/EBP), alpha". 
  5. ^ a b Wang H, Iakova P, Wilde M, Welm A, Goode T, Roesler WJ, Timchenko NA (October 2001). "C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4". Mol. Cell 8 (4): 817–28. doi:10.1016/S1097-2765(01)00366-5. PMID 11684017. 
  6. ^ Ho PA, Alonzo TA, Gerbing RB, Pollard J, Stirewalt DL, Hurwitz C, Heerema NA, Hirsch B, Raimondi SC, Lange B, Franklin JL, Radich JP, Meshinchi S (June 2009). "Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group". Blood 113 (26): 6558–66. doi:10.1182/blood-2008-10-184747. PMC 2943755. PMID 19304957. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.