ETS1

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V-ets avian erythroblastosis virus E26 oncogene homolog 1
Protein ETS1 PDB 1bqv.png
PDB rendering based on 1bqv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ETS1 ; ETS-1; EWSR2; p54
External IDs OMIM164720 MGI95455 HomoloGene3837 GeneCards: ETS1 Gene
RNA expression pattern
PBB GE ETS1 214447 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2113 23871
Ensembl ENSG00000134954 ENSMUSG00000032035
UniProt P14921 P27577
RefSeq (mRNA) NM_001143820 NM_001038642
RefSeq (protein) NP_001137292 NP_001033731
Location (UCSC) Chr 11:
128.33 – 128.46 Mb
Chr 9:
32.64 – 32.76 Mb
PubMed search [1] [2]

Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene.[1] The protein encoded by this gene belongs to the ETS family of transcription factors.[2]

Interactions[edit]

ETS1 has been shown to interact with TTRAP,[3] UBE2I[4] and Death associated protein 6.[5]

References[edit]

  1. ^ Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, de Jong P, Rouleau G, et al. (October 1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours". Nature 359 (6391): 162–5. doi:10.1038/359162a0. PMID 1522903. 
  2. ^ Dwyer J, Li H, Xu D, Liu JP (October 2007). "Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family". Ann. N. Y. Acad. Sci. 1114 (1): 36–47. doi:10.1196/annals.1396.022. PMID 17986575. 
  3. ^ Pei, Huiping; Yordy John S; Leng Qixin; Zhao Qinghua; Watson Dennis K; Li Runzhao (May 2003). "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene (England) 22 (18): 2699–709. doi:10.1038/sj.onc.1206374. ISSN 0950-9232. PMID 12743594. 
  4. ^ Hahn, S L; Wasylyk B; Criqui-Filipe P; Criqui P (September 1997). "Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme". Oncogene (ENGLAND) 15 (12): 1489–95. doi:10.1038/sj.onc.1201301. ISSN 0950-9232. PMID 9333025. 
  5. ^ Li, R; Pei H; Watson D K; Papas T S (February 2000). "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes". Oncogene (ENGLAND) 19 (6): 745–53. doi:10.1038/sj.onc.1203385. ISSN 0950-9232. PMID 10698492. 

Further reading[edit]

  • Reddy ES, Rao VN (1988). "Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene". Oncogene Res. 3 (3): 239–46. PMID 3060801. 
  • Lincoln DW, Bove K (2006). "The transcription factor Ets-1 in breast cancer.". Front. Biosci. 10 (1-3): 506–11. doi:10.2741/1546. PMID 15574387. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.