KLK1

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Kallikrein 1
Protein KLK1 PDB 1spj.png
PDB rendering based on 1spj.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KLK1 ; KLKR; Klk6; hK1
External IDs OMIM147910 MGI97322 HomoloGene110727 ChEMBL: 2319 GeneCards: KLK1 Gene
EC number 3.4.21.35
RNA expression pattern
PBB GE KLK1 216699 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3816 18050
Ensembl ENSG00000167748 ENSMUSG00000066515
UniProt P06870 Q62284
RefSeq (mRNA) NM_002257 NM_008693
RefSeq (protein) NP_002248 NP_032719
Location (UCSC) Chr 19:
51.32 – 51.33 Mb
Chr 7:
44.07 – 44.07 Mb
PubMed search [1] [2]

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene.[1][2][3] KLK1 is a member of the peptidase S1 family.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.[4]

References[edit]

  1. ^ Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, Shaw D (Feb 1992). "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker". Genomics 11 (1): 77–82. doi:10.1016/0888-7543(91)90103-L. PMID 1684954. 
  2. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  3. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  4. ^ "Entrez Gene: KLK1 kallikrein 1". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.160