Batroxobin

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Batroxobin
Clinical data
AHFS/Drugs.com International Drug Names
Legal status [1] (US)
Identifiers
CAS number 9039-61-6 YesY
ATC code B02BX03
Chemical data
Formula ?
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Batroxobin is a serine protease[2] derived from the venom of Bothrops atrox. Its molecular weight is approximately 43,000 g/mol−1.

This thrombin-like proteolytic enzyme splits the 16 Arg-17 Gly bond in the A(alpha)-chain of fibrinogen, releasing fibrinopeptide A and leading to the clot formation through aggregation of formed of fibrin I monomer or Des-AA-monomer.[3] In contrast to other anti-coagulants, it does not affect the functions of platelets. Hence, Batroxobin is used to determine fibrinogen in plasma, to measure a 'batroxobin clotting time' as a heparin-insensitive parallel to the thrombin time, to investigate dysfibrinogenemia, and to test the contractile system of platelets[4]

References[edit]

  1. ^ Batroxobin technical sheet
  2. ^ Lochnit G, Geyer R (March 1995). "Carbohydrate structure analysis of batroxobin, a thrombin-like serine protease from Bothrops moojeni venom". Eur. J. Biochem. 228 (3): 805–16. doi:10.1111/j.1432-1033.1995.tb20326.x. PMID 7737180. 
  3. ^ Technical sheet of Batroxobin from PentaPharm
  4. ^ Application of snake venom proteins in the diagnosis of hemostatic disorders in 'Medical Use of Snake Venom Proteins, Stocker K, ed. Boca Raton: CRC-Press 1990; 213-52'

External links[edit]