The Lions took an early 14–0 lead by early in the second quarter, following a 9-yard TD reception by [[Golden Tate]] and a 41-yard interception return by [[Rashean Mathis]]. But that would end Detroit's scoring for the day. Buffalo came back on field goals of 45 and 25 yards by [[Dan Carpenter]], making the score 14–6 by the start of the fourth quarter. [[Kyle Orton]] hit [[Chris Gragg] with a 2-yard TD pass, and the ensuing two-point conversion knotted the score at 14–14. With 21 seconds left in the game, [[Alex Henery]] missed a 50-yard field goal attempt, his third miss of the day. The Bills quickly moved the ball to the Lions' 40-yard line, setting up Carpenter's game-winning 58-yard field goal with 9 seconds remaining.
The Lions traded their fifth round pick (146 overall) to Dallas in exchange for a fifth round pick (158 overall) and a seventh round pick (229 overall).[55]
The Lions hosted their first opening-day Monday Night Football game since 1971, rudely welcoming the New York Giants to town. Matthew Stafford connected with Calvin Johnson on TD passes of 67 and 16 yards in the first quarter, giving Detroit an early 14–0 lead. The Giants got on the board in the second quarter with a 1-yard TD pass from Eli Manning to Larry Donnell, closing the gap to 14–7. Rookie kicker Nate Freese connected on field goals of 28 and 27 yards in the third quarter to extend the Lions lead to 20–7. An interception by Glover Quin, Detroit's second pick of the game, set up the Lions next touchdown, a 5-yard run by Stafford. New York narrowed the lead to 27–14 early in the fourth quarter when Rashad Jennings plunged in from a yard out, but that was as close as the Giants would get. Joique Bell capped the scoring with a 3-yard TD run, and the ensuing 2-point conversion made the final score 35–14.
Week 2: at Carolina Panthers
Week Two: Detroit Lions at Carolina Panthers – Game summary
Carolina's Cam Newton made a successful comeback from a rib injury that kept him out of action in Week 1, but the story of the day was the Panthers' defense. Carolina forced three Detroit turnovers, two of which led directly to scores. Graham Gano opened the scoring for Carolina in the second quarter with field goals of 29 and 53 yards. The Lions took a 7–6 lead in the third quarter when Matthew Stafford hit fullback Jed Collins with a 1-yard TD pass. But the rest of the game was all Carolina. Newton closed the third with a 14-yard TD pass to Jason Avant to retake the lead, 13–7. In the fourth quarter, Jonathan Stewart found the end zone on a 2-yard TD run, with the ensuing 2-point conversion giving the Panthers a 21–7 lead. Gano finished the scoring with a 38-yard field goal.
Week 3: vs. Green Bay Packers
Week Three: Green Bay Packers at Detroit Lions – Game summary
The Lions faced division rival Green Bay in Week 3, with Packers QB Aaron Rodgers sporting a 9–1 record in his last ten games against Detroit. The first two scoring plays for the Lions came courtesy of the defense. Nick Fairley forced a fumble that was scooped up by defensive back Don Carey and returned 40 yards to paydirt to put the Lions up 7–0. After Rodgers tied the game with a 10-yard TD pass to Andrew Quarless, DeAndre Levy tackled running back Eddie Lacy in the end zone for a safety, making the score 9–7. Nate Freese closed the first half scoring with a 30-yard field goal, sending Detroit to the locker room with a 12–7 lead. The only scoring drive of the second half culminated with a Reggie Bush 26-yard TD run, to put Detroit up 19–7. The Lions defense held Green Bay scoreless for the final three quarters of the game.
Week 4: at New York Jets
Week Four: Detroit Lions at New York Jets – Game summary
After opening the season 3-for-7 on field goal attempts, Detroit kicker Nate Freese was cut during the week and was replaced by Alex Henery. Henery made good on his first FG attempt for his new team, a 51-yarder to tie the Jets at 3–3 in the first quarter. The Lions put together two TD drives in the second quarter to go up 17–3. First, Matthew Stafford hit Jeremy Ross on a 59-yard bomb. Stafford then connected with first-round draft pick Eric Ebron for a 16-yard TD, giving Ebron his first NFL touchdown. Jets QB Geno Smith hit Eric Decker with an 11-yard TD pass to close the gap to 17–10. Early in the fourth, Stafford found the right pylon for a 1-yard TD run, making the score 24–10. Chris Johnson rambled 35 yards for a touchdown midway through the final quarter, pulling the Jets within a touchdown again, at 24–17. But Detroit's defense was able to force a punt on New York's final possession, and the Lions ran out the clock thereafter.
Week 5: vs. Buffalo Bills
Week Five: Buffalo Bills at Detroit Lions – Game summary
The Lions took an early 14–0 lead by early in the second quarter, following a 9-yard TD reception by Golden Tate and a 41-yard interception return by Rashean Mathis. But that would end Detroit's scoring for the day. Buffalo came back on field goals of 45 and 25 yards by Dan Carpenter, making the score 14–6 by the start of the fourth quarter. Kyle Orton hit [[Chris Gragg] with a 2-yard TD pass, and the ensuing two-point conversion knotted the score at 14–14. With 21 seconds left in the game, Alex Henery missed a 50-yard field goal attempt, his third miss of the day. The Bills quickly moved the ball to the Lions' 40-yard line, setting up Carpenter's game-winning 58-yard field goal with 9 seconds remaining.
Week 6: at Minnesota Vikings
Week Six: Detroit Lions at Minnesota Vikings – Game summary
^ abcThe NY Giants defeated both Atlanta and St. Louis head-to-head (Atlanta: Week 5, 30–20; St. Louis: Week 16, 37–27), while Atlanta finished ahead of St. Louis based on conference record.
^When breaking ties for three or more teams under the NFL's rules, they are first broken within divisions, then comparing only the highest-ranked remaining team from each division.