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3-deoxy-D-manno-octulosonic acid kinase

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3-deoxy-D-manno-octulosonic acid kinase
Identifiers
EC no.2.7.1.166
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BRENDABRENDA entry
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3-deoxy-D-manno-octulosonic acid kinase (EC 2.7.1.166, kdkA (gene), Kdo kinase) is an enzyme with systematic name ATP:(KDO)-lipid IVA 3-deoxy-alpha-D-manno-oct-2-ulopyranose 4-phosphotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

alpha-Kdo-(2->6)-lipid IVA + ATP 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP

The enzyme phosphorylates the 4-OH position of KDO in (KDO)-lipid IVA.

References

  1. ^ Brabetz, W.; Muller-Loennies, S.; Brade, H. (2000). "3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout mutation of Escherichia coli". J. Biol. Chem. 275: 34954–34962. doi:10.1074/jbc.M005204200. PMID 10952982.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  2. ^ Harper, M.; Boyce, J.D.; Cox, A.D.; St Michael, F.; Wilkie, I.W.; Blackall, P.J.; Adler, B. (2007). "Pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: identification of two acceptor-specific heptosyl I transferases". Infect. Immun. 75: 3885–3893. doi:10.1128/IAI.00212-07. PMID 17517879.
  3. ^ White, K.A.; Kaltashov, I.A.; Cotter, R.J.; Raetz, C.R. (1997). "A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae". J. Biol. Chem. 272: 16555–16563. doi:10.1074/jbc.272.26.16555. PMID 9195966.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ White, K.A.; Lin, S.; Cotter, R.J.; Raetz, C.R. (1999). "A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence". J. Biol. Chem. 274 (44): 31391–31400. doi:10.1074/jbc.274.44.31391. PMID 10531340.{{cite journal}}: CS1 maint: unflagged free DOI (link)
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