POLRMT

From Wikipedia, the free encyclopedia
Jump to: navigation, search
POLRMT
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases POLRMT, APOLMT, MTRNAP, MTRPOL, h-mtRPOL, polymerase (RNA) mitochondrial
External IDs MGI: 1915843 HomoloGene: 37996 GeneCards: POLRMT
RNA expression pattern
PBB GE POLRMT 203782 s at fs.png

PBB GE POLRMT 203783 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005035

NM_172551

RefSeq (protein)

NP_005026

NP_766139.2
NP_766139

Location (UCSC) Chr 19: 0.62 – 0.63 Mb Chr 10: 79.74 – 79.75 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase, mitochondrial is an enzyme that in humans is encoded by the POLRMT gene.[3][4]

Function[edit]

This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of bacteriophage and mitochondrial polymerases of lower eukaryotes.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Tiranti V, Savoia A, Forti F, D'Apolito MF, Centra M, Rocchi M, Zeviani M (Jul 1997). "Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence Tags database". Hum Mol Genet. 6 (4): 615–25. doi:10.1093/hmg/6.4.615. PMID 9097968. 
  4. ^ a b "Entrez Gene: POLRMT polymerase (RNA) mitochondrial (DNA directed)". 

Further reading[edit]