Nacolomab tafenatox
Appearance
Monoclonal antibody | |
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Type | Fab fragment |
Source | Mouse |
Target | colorectal tumor antigen C242 |
Clinical data | |
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Nacolomab tafenatox is a mouse monoclonal antibody.[1][2] The antibody itself, nacolomab, is fused with enterotoxin A from Staphylococcus aureus (which is reflected by 'tafenatox' in the drug's name).[1]
![](http://upload.wikimedia.org/wikipedia/commons/thumb/d/de/Fab-superantigen-fusion_protein.svg/220px-Fab-superantigen-fusion_protein.svg.png)
VH, VL: variable (antigen binding) domains of antibody fragment
CH1, CL: constant domains of antibody fragment
SAg: enterotoxin A (acting as a superantigen)
See also
- Naptumomab estafenatox, a drug with a similar chemical structure and mechanism
References
- ^ a b "Recommended INN List: Nacolomab tafenatox" (PDF). WHO Drug Information. 9 (3): 182. 1995. Archived from the original (PDF) on 23 February 2012.
- ^ Alpaugh RK, Weiner LM, Persson B, Persson R, Dohlsten M, Kalland T (1997). "Nacolomab Tafenatox". Drugs of the Future. 22 (11): 1226–30.