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Iotapapillomavirus

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Iotapapillomavirus
Virus classification Edit this classification
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Papovaviricetes
Order: Zurhausenvirales
Family: Papillomaviridae
Genus: Iotapapillomavirus

Iotapapillomavirus is a genus of viruses, in the family Papillomaviridae.[1] Rodents serve as natural hosts. There are currently two species in this genus, including the type species Iotapapillomavirus 1. Diseases associated with this genus include: cutaneous lesions and benign skin tumours, such as papillomas and keratoacanthomas.[2][3]

Taxonomy

Group: dsDNA

Order: Zurhausenvirales
    • Genus: Iotapapillomavirus

[3]

Structure

Viruses in Iotapapillomavirus are non-enveloped, with icosahedral geometries, and T=7 symmetry. The diameter is around 60 nm. Genomes are circular, around 8kb in length.[2]

Genus Structure Symmetry Capsid Genomic arrangement Genomic segmentation
Iotapapillomavirus Icosahedral T=7 Non-enveloped Circular Monopartite

Life cycle

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear envelope breakdown. Rodents serve as the natural host. Transmission routes are contact.[2]

Genus Host details Tissue tropism Entry details Release details Replication site Assembly site Transmission
Iotapapillomavirus Rodents Epithelial: mucous; epithelial: skin Cell receptor endocytosis Lysis Nucleus Nucleus Contact

References

  1. ^ Van Doorslaer, K; Chen, Z; Bernard, HU; Chan, PKS; DeSalle, R; Dillner, J; Forslund, O; Haga, T; McBride, AA; Villa, LL; Burk, RD; ICTV Report Consortium (August 2018). "ICTV Virus Taxonomy Profile: Papillomaviridae". The Journal of General Virology. 99 (8): 989–990. doi:10.1099/jgv.0.001105. PMC 6171710. PMID 29927370.
  2. ^ a b c "Viral Zone". ExPASy. Retrieved 15 June 2015.
  3. ^ a b "ICTV Report Papillomaviridae".
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