OR3A1

OR3A1
Identifiers
Aliases	OR3A1, OLFRA03, OR17-40, OR17-82, OR40, olfactory receptor family 3 subfamily A member 1, olfactory receptor family 3 subfamily A member 1 (gene/pseudogene)
External IDs	MGI: 3030236; HomoloGene: 1915; GeneCards: OR3A1; OMA:OR3A1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.3 Start 3,291,017 bp End 3,298,360 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B5 Start 74,044,355 bp End 74,048,987 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle secondary oocyte gonad islet of Langerhans ventricular zone prefrontal cortex urinary bladder right testis left testis gallbladder n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4994 258703 Ensembl ENSG00000180090 ENSMUSG00000070379 UniProt P47881 Q8VFX8 RefSeq (mRNA) NM_002550 NM_146708 RefSeq (protein) NP_002541 NP_666919 Location (UCSC) Chr 17: 3.29 – 3.3 Mb Chr 11: 74.04 – 74.05 Mb PubMed search
Wikidata
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Olfactory receptor 3A1 is a protein that in humans is encoded by the OR3A1 gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Ligands

OR3A1 is activated by helional and the closely related molecule heliotropylacetone. Other compounds including piperonal, safrole, and vanillin completely failed to activate OR3A1.

Agonists:

• helional
• heliotropylacetone
• lilial
• cyclamen aldehyde
• foliaver (3-(4-methoxyphenyl)-2-methylpropanal)

See also

• Olfactory receptor

Further reading

• Marrakchi M, Vidic J, Jaffrezic-Renault N, Martelet C, Pajot-Augy E (November 2007). "A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40". European Biophysics Journal. 36 (8): 1015–8. doi:10.1007/s00249-007-0187-6. PMID 17579849. S2CID 11099976.
• Jacquier V, Prummer M, Segura JM, Pick H, Vogel H (September 2006). "Visualizing odorant receptor trafficking in living cells down to the single-molecule level". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14325–30. doi:10.1073/pnas.0603942103. PMC 1599963. PMID 16980412.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, et al. (January 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334.
• Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, et al. (February 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Human Molecular Genetics. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.

External links

• OR3A1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.