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Adenosylcobinamide-GDP ribazoletransferase (EC 2.7.8.26 , CobS , cobalamin synthase , cobalamin-5'-phosphate synthase , cobalamin (5'-phosphate) synthase ) is an enzyme with systematic name adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase .[1] [2] [3] This enzyme catalyses the following chemical reaction
(1) adenosylcobinamide-GDP + alpha-ribazole
⇌
{\displaystyle \rightleftharpoons }
GMP + adenosylcobalamin
(2) adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate
⇌
{\displaystyle \rightleftharpoons }
GMP + adenosylcobalamin 5'-phosphate
References
^ Maggio-Hall, L.A.; Escalante-Semerena, J.C. (1999). "In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes" . Proc. Natl. Acad. Sci. USA . 96 : 11798–11803. doi :10.1073/pnas.96.21.11798 . PMC 18366 . PMID 10518530 .
^ Warren, M.J.; Raux, E.; Schubert, H.L.; Escalante-Semerena, J.C. (2002). "The biosynthesis of adenosylcobalamin (vitamin B12 )". Nat. Prod. Rep . 19 : 390–412. doi :10.1039/b108967f . PMID 12195810 .
^ Cameron, B.; Blanche, F.; Rouyez, M.C.; Bisch, D.; Famechon, A.; Couder, M.; Cauchois, L.; Thibaut, D.; Debussche, L.; Crouzet, J. (1991). "Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5′-phosphate) synthase" . J. Bacteriol . 173 (19): 6066–6073. PMC 208353 . PMID 1917841 .
External links
Activity Regulation Classification Kinetics Types