Bornavirus

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Bornavirus
Virus classification
Group: Group V ((-)ssRNA)
Order: Mononegavirales
Family: Bornaviridae
Genus: Bornavirus
Type Species

Bornavirus is a genus of viruses in the order Mononegavirales. Horses, sheep, cattle, rodents, birds, and human serve as natural hosts. There are currently five species in this genus, and it is the only genus in its family (Bornaviridae). Diseases associated with this genus include: mammals borna disease : fatal neurologic disease, restricted to central europe. birds: encephalitis, proventricular dilatation disease.[1][2]

Taxonomy[edit]

Group: ssRNA(-)

[2]

Structure[edit]

Viruses in Bornavirus are enveloped, with spherical geometries. The diameter is around 70 to 130 nm. Genomes are linear, around 8.9kb in length. The genome codes for 9 proteins. [1]

Genus Structure Symmetry Capsid Genomic Arrangement Genomic Segmentation
Bornavirus Spherical Enveloped Linear Monopartite

Life Cycle[edit]

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral GP glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus replication model. Negative stranded rna virus transcription, using polymerase stuttering, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear pore export. Horses, sheep, cattle, rodents, birds, and humans serve as the natural host. Transmission routes are fomite, contact, urine, feces, and saliva.[1]

Genus Host Details Tissue Tropism Entry Details Release Details Replication Site Assembly Site Transmission
Bornavirus Horses; sheep; cattle; rodents; birds; humans Neurons; astrocytes; oligodendrocytes; ependymal cells Clathrin-mediated endocytosis Budding Cytoplasm Cytoplasm Fomites; contact: saliva; contact: urine; contact: feces

Pathogenicity[edit]

Between 2011 and 2013, three breeders of variegated squirrels (Sciurus variegatoides) had encephalitis with similar clinical signs and died 2 to 4 months after onset of the clinical symptoms. Genomic analysis found a previously unknown bornavirus in a contact squirrel and in brain tissue from the three men, the researchers reported, and it is the "likely causative agent" in their deaths. Prior to this, Bornavirus species were not thought to be responsible for human diseases.[3][4]

References[edit]

External Links[edit]