|Synonyms||acute viral nasopharyngitis, nasopharyngitis, viral rhinitis, rhinopharyngitis, acute coryza, head cold|
|A representation of the molecular surface of one variant of human rhinovirus.|
|Classification and external resources|
|Patient UK||Common cold|
Common cold, also known simply as a cold, is a viral infectious disease of the upper respiratory tract that primarily affects the nose. The throat, sinuses, and voice box may also be affected. Signs and symptoms may begin less than two days following exposure. They include coughing, sore throat, runny nose, sneezing, headache, and fever. People usually recover in seven to ten days. Some symptoms may last up to three weeks. In those with other health problems, pneumonia may occasionally develop.
Well over 200 virus strains are implicated in the cause of the common cold; the rhinoviruses are the most common. They spread through the air during close contact with infected people and indirectly through contact with objects in the environment followed by transfer to the mouth or nose. Risk factors include going to daycare, not sleeping well, and psychological stress. Symptoms are mostly due to the body's immune response to the infection rather than to tissue destruction by the viruses themselves. People with influenza often show similar symptoms as people with a cold, though symptoms are usually more severe in the former. Influenza is less likely to result in a runny nose.
There is no vaccine for the common cold. The primary methods of prevention are hand washing; not touching the eyes, nose or mouth with unwashed hands; and staying away from other sick people. Some evidence supports the use of face masks. No cure for the common cold exists, but the symptoms can be treated. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen may help with pain. Antibiotics should not be used. Evidence does not support a benefit from cough medicines.
The common cold is the most frequent infectious disease in humans. The average adult gets two to four colds a year, while the average child may get six to eight. They occur more commonly during the winter. These infections have been with humanity since ancient times.
- 1 Signs and symptoms
- 2 Cause
- 3 Pathophysiology
- 4 Diagnosis
- 5 Prevention
- 6 Management
- 7 Prognosis
- 8 Epidemiology
- 9 History
- 10 Society and culture
- 11 Research directions
- 12 References
- 13 External links
Signs and symptoms
The typical symptoms of a cold include a cough, a runny nose, nasal congestion and a sore throat, sometimes accompanied by muscle ache, fatigue, headache, and loss of appetite. A sore throat is present in about 40% of the cases and a cough in about 50%, while muscle ache occurs in about half. In adults, a fever is generally not present but it is common in infants and young children. The cough is usually mild compared to that accompanying influenza. While a cough and a fever indicate a higher likelihood of influenza in adults, a great deal of similarity exists between these two conditions. A number of the viruses that cause the common cold may also result in asymptomatic infections.
A cold usually begins with fatigue, a feeling of being chilled, sneezing, and a headache, followed in a couple of days by a runny nose and cough. Symptoms may begin within sixteen hours of exposure and typically peak two to four days after onset. They usually resolve in seven to ten days, but some can last for up to three weeks. The average duration of cough is eighteen days and in some cases people develop a post-viral cough which can linger after the infection is gone. In children, the cough lasts for more than ten days in 35%–40% of the cases and continues for more than 25 days in 10%.
The common cold is a viral infection of the upper respiratory tract. The most commonly implicated virus is a rhinovirus (30%–80%), a type of picornavirus with 99 known serotypes. Other commonly implicated viruses include human coronavirus (≈15%), influenza viruses (10%–15%), adenoviruses (5%), human respiratory syncytial virus, enteroviruses other than rhinoviruses, human parainfluenza viruses, and metapneumovirus. Frequently more than one virus is present. In total over 200 different viral types are associated with colds.
The common cold virus is typically transmitted via airborne droplets (aerosols), direct contact with infected nasal secretions, or fomites (contaminated objects). Which of these routes is of primary importance has not been determined; however, hand-to-hand and hand-to-surface-to-hand contact seems of more importance than transmission via aerosols. The viruses may survive for prolonged periods in the environment (over 18 hours for rhinoviruses) and can be picked up by people's hands and subsequently carried to their eyes or nose where infection occurs. Transmission is common in daycare and at school due to the proximity of many children with little immunity and frequently poor hygiene. These infections are then brought home to other members of the family. There is no evidence that recirculated air during commercial flight is a method of transmission. People sitting in close proximity appear to be at greater risk of infection.
Rhinovirus-caused colds are most infectious during the first three days of symptoms; they are much less infectious afterwards.
The traditional theory is that a cold can be "caught" by prolonged exposure to cold weather such as rain or winter conditions, which is how the disease got its name. Some of the viruses that cause the common colds are seasonal, occurring more frequently during cold or wet weather. The reason for the seasonality has not been conclusively determined. Possible explanations may include cold temperature-induced changes in the respiratory system, decreased immune response, and low humidity causing an increase in viral transmission rates, perhaps due to dry air allowing small viral droplets to disperse farther and stay in the air longer.
The apparent seasonality may also be due to social factors, such as people spending more time indoors, near infected people, and specifically children at school. There is some controversy over the role of low body temperature as a risk factor for the common cold; the majority of the evidence suggests that it may result in greater susceptibility to infection.
Herd immunity, generated from previous exposure to cold viruses, plays an important role in limiting viral spread, as seen with younger populations that have greater rates of respiratory infections. Poor immune function is a risk factor for disease. Insufficient sleep and malnutrition have been associated with a greater risk of developing infection following rhinovirus exposure; this is believed to be due to their effects on immune function. Breast feeding decreases the risk of acute otitis media and lower respiratory tract infections among other diseases, and it is recommended that breast feeding be continued when an infant has a cold. In the developed world breast feeding may not be protective against the common cold in and of itself.
The symptoms of the common cold are believed to be primarily related to the immune response to the virus. The mechanism of this immune response is virus specific. For example, the rhinovirus is typically acquired by direct contact; it binds to human ICAM-1 receptors through unknown mechanisms to trigger the release of inflammatory mediators. These inflammatory mediators then produce the symptoms. It does not generally cause damage to the nasal epithelium. The respiratory syncytial virus (RSV), on the other hand, is contracted by direct contact and airborne droplets. It then replicates in the nose and throat before frequently spreading to the lower respiratory tract. RSV does cause epithelium damage. Human parainfluenza virus typically results in inflammation of the nose, throat, and bronchi. In young children when it affects the trachea it may produce the symptoms of croup due to the small size of their airways.
The distinction between viral upper respiratory tract infections is loosely based on the location of symptoms with the common cold affecting primarily the nose, pharyngitis the throat, and bronchitis the lungs. However, there can be significant overlap and multiple areas can be affected. The common cold is frequently defined as nasal inflammation with varying amount of throat inflammation. Self-diagnosis is frequent. Isolation of the viral agent involved is rarely performed, and it is generally not possible to identify the virus type through symptoms.
The only useful ways to reduce the spread of cold viruses are physical measures such as hand washing and face masks; in the healthcare environment, gowns and disposable gloves are also used. Isolation or quarantine is not used as the disease is so widespread and symptoms are non-specific. Vaccination has proved difficult as there are many viruses involved and they mutate rapidly. Creation of a broadly effective vaccine is, thus, highly improbable.
Regular hand washing appears to be effective in reducing the transmission of cold viruses, especially among children. Whether the addition of antivirals or antibacterials to normal hand washing provides greater benefit is unknown. Wearing face masks when around people who are infected may be beneficial; however, there is insufficient evidence for maintaining a greater social distance.
Zinc supplements may help to reduce the prevalence of colds. Routine vitamin C supplements do not reduce the risk or severity of the common cold, though they may reduce its duration. Gargling with water was found useful in one small trial.
No medications or herbal remedies have been conclusively demonstrated to shorten the duration of infection. Treatment thus comprises symptomatic relief. Getting plenty of rest, drinking fluids to maintain hydration, and gargling with warm salt water are reasonable conservative measures. Much of the benefit from treatment is, however, attributed to the placebo effect.
Treatments that help with symptoms include simple pain medication and medications for fevers such as ibuprofen[needs update] and acetaminophen/paracetamol. There is not good evidence for cough medicines.[needs update] Cough medicine are not recommended for use in children due to a lack of evidence supporting effectiveness and the potential for harm. In 2009, Canada restricted the use of over-the-counter cough and cold medication in children six years and under due to concerns regarding risks and unproven benefits. The misuse of dextromethorphan (an over-the-counter cough medicine) has led to its ban in a number of countries.
In adults short term use of nasal decongestants may have a small benefit. Antihistamines may improve symptoms in the first day or two; however, there is no longer-term benefit and they have adverse effects such as drowsiness. Other decongestants such as pseudoephedrine appear effective in adults. Ipratropium nasal spray may reduce the symptoms of a runny nose but has little effect on stuffiness.[needs update] The safety and effectiveness of nasal decongestant use in children is unclear.
Due to lack of studies, it is not known whether increased fluid intake improves symptoms or shortens respiratory illness, and there is a similar lack of data for the use of heated humidified air. One study has found chest vapor rub to provide some relief of nocturnal cough, congestion, and sleep difficulty.
Antibiotics have no effect against viral infections or against the viruses that cause the common cold. Due to their side effects, antibiotics cause overall harm but are still frequently prescribed. Some of the reasons that antibiotics are so commonly prescribed include people's expectations for them, physicians' desire to help, and the difficulty in excluding complications that may be amenable to antibiotics. There are no effective antiviral drugs for the common cold even though some preliminary research has shown benefits.
While there are many alternative treatments used for the common cold, there is insufficient scientific evidence to support the use of most. As of 2014 there is insufficient evidence to recommend for or against honey. As of 2015 there is tentative evidence to support nasal irrigation. Zinc has been used to treat symptoms, with studies suggesting that zinc, if taken within 24 hours of the onset of symptoms, reduces the duration and severity of the common cold in otherwise healthy people. Due to wide differences between the studies, further research may be needed to determine how and when zinc may be effective. Whereas zinc lozenges may produce side effects, there is only a weak rationale for physicians to recommend zinc for the treatment of the common cold. Some zinc remedies directly applied to the inside of the nose have led to the loss of the sense of smell.
Vitamin C's effect on the common cold, while extensively researched, is disappointing, except in limited circumstances: specifically, individuals exercising vigorously in cold environments. There is no firm evidence that Echinacea products provide any meaningful benefit in treating or preventing colds. It is unknown if garlic is effective. A single trial of vitamin D did not find benefit.
The common cold is generally mild and self-limiting with most symptoms generally improving in a week. Half of cases go away in 10 days and 90% in 15 days. Severe complications, if they occur, are usually in the very old, the very young, or those who are immunosuppressed. Secondary bacterial infections may occur resulting in sinusitis, pharyngitis, or an ear infection. It is estimated that sinusitis occurs in 8% and ear infection in 30% of cases.
The common cold is the most common human disease and affects people all over the globe. Adults typically have two to five infections annually, and children may have six to ten colds a year (and up to twelve colds a year for school children). Rates of symptomatic infections increase in the elderly due to declining immunity.
Native Americans and Inuit are more likely to be infected with colds and develop complications such as otitis media than Caucasians. This may be explained by issues such as poverty and overcrowding rather than by ethnicity.
While the cause of the common cold has only been identified since the 1950s, the disease has been with humanity since ancient times. Its symptoms and treatment are described in the Egyptian Ebers papyrus, the oldest existing medical text, written before the 16th century BCE. The name "cold" came into use in the 16th century, due to the similarity between its symptoms and those of exposure to cold weather.
In the United Kingdom, the Common Cold Unit was set up by the Medical Research Council in 1946 and it was where the rhinovirus was discovered in 1956. In the 1970s, the CCU demonstrated that treatment with interferon during the incubation phase of rhinovirus infection protects somewhat against the disease, but no practical treatment could be developed. The unit was closed in 1989, two years after it completed research of zinc gluconate lozenges in the prophylaxis and treatment of rhinovirus colds, the only successful treatment in the history of the unit.
Society and culture
The economic impact of the common cold is not well understood in much of the world. In the United States, the common cold leads to 75–100 million physician visits annually at a conservative cost estimate of $7.7 billion per year. Americans spend $2.9 billion on over-the-counter drugs and another $400 million on prescription medicines for symptom relief. More than one-third of people who saw a doctor received an antibiotic prescription, which has implications for antibiotic resistance. An estimated 22–189 million school days are missed annually due to a cold. As a result, parents missed 126 million workdays to stay home to care for their children. When added to the 150 million workdays missed by employees suffering from a cold, the total economic impact of cold-related work loss exceeds $20 billion per year. This accounts for 40% of time lost from work in the United States.
Antivirals have been tested for effectiveness in the common cold; as of 2009, none had been both found effective and licensed for use. There are ongoing trials of the anti-viral drug pleconaril which shows promise against picornaviruses as well as trials of BTA-798. The oral form of pleconaril had safety issues and an aerosol form is being studied. DRACO, a broad-spectrum antiviral therapy, has shown preliminary effectiveness in treating rhinovirus, as well as other infectious viruses.
- John, Pramod R. John (2008). Textbook of Oral Medicine. Jaypee Brothers Publishers. p. 336. ISBN 9788180615627.
- Arroll, B (March 2011). "Common cold". Clinical evidence. 2011 (3): 1510. PMC . PMID 21406124.
Common colds are defined as upper respiratory tract infections that affect the predominantly nasal part of the respiratory mucosa
- Allan, GM; Arroll, B (18 February 2014). "Prevention and treatment of the common cold: making sense of the evidence.". CMAJ : Canadian Medical Association. 186 (3): 190–9. doi:10.1503/cmaj.121442. PMC . PMID 24468694.
- "Common Colds: Protect Yourself and Others". CDC. 6 October 2015. Retrieved 4 February 2016.
- Eccles R (November 2005). "Understanding the symptoms of the common cold and influenza". Lancet Infect Dis. 5 (11): 718–25. doi:10.1016/S1473-3099(05)70270-X. PMID 16253889.
- Heikkinen T, Järvinen A (January 2003). "The common cold". Lancet. 361 (9351): 51–9. doi:10.1016/S0140-6736(03)12162-9. PMID 12517470.
- "Common Cold and Runny Nose" (17 April 2015). CDC. Retrieved 4 February 2016.
- Eccles p. 112
- "Cold Versus Flu". August 11, 2016. Retrieved January 5, 2017.
- Eccles p. 209
- Kim, SY; Chang, YJ; Cho, HM; Hwang, YW; Moon, YS (21 September 2015). "Non-steroidal anti-inflammatory drugs for the common cold.". The Cochrane database of systematic reviews. 9: CD006362. doi:10.1002/14651858.CD006362.pub4. PMID 26387658.
- Harris, AM; Hicks, LA; Qaseem, A; High Value Care Task Force of the American College of Physicians and for the Centers for Disease Control and, Prevention (19 January 2016). "Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American College of Physicians and the Centers for Disease Control and Prevention.". Annals of Internal Medicine. 164: 425. doi:10.7326/M15-1840. PMID 26785402.
- Eccles p. 1
- Simasek M, Blandino DA (2007). "Treatment of the common cold". American Family Physician. 75 (4): 515–20. PMID 17323712.
- Eccles, Ronald; Weber, Olaf (2009). Common cold. Basel: Birkhäuser. p. 3. ISBN 978-3-7643-9894-1.
- Eccles p. 24
- Eccles p. 26
- Eccles p. 129
- Eccles p. 50
- Eccles p. 30
- Richard A. Helms, ed. (2006). Textbook of therapeutics: drug and disease management (8. ed.). Philadelphia, Pa. [u.a.]: Lippincott Williams & Wilkins. p. 1882. ISBN 9780781757348.
- al.], edited by Helga Rübsamen-Waigmann ... [et (2003). Viral Infections and Treatment. Hoboken: Informa Healthcare. p. 111. ISBN 9780824756413.
- Ebell, M. H.; Lundgren, J.; Youngpairoj, S. (Jan–Feb 2013). "How long does a cough last? Comparing patients' expectations with data from a systematic review of the literature.". Annals of Family Medicine. 11 (1): 5–13. doi:10.1370/afm.1430. PMC . PMID 23319500.
- Dicpinigaitis PV (May 2011). "Cough: an unmet clinical need". Br. J. Pharmacol. 163 (1): 116–24. doi:10.1111/j.1476-5381.2010.01198.x. PMC . PMID 21198555.
- Goldsobel AB, Chipps BE (March 2010). "Cough in the pediatric population". J. Pediatr. 156 (3): 352–358.e1. doi:10.1016/j.jpeds.2009.12.004. PMID 20176183.
- Palmenberg AC, Spiro D, Kuzmickas R, Wang S, Djikeng A, Rathe JA, Fraser-Liggett CM, Liggett SB (2009). "Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveals Structure and Evolution". Science. 324 (5923): 55–9. doi:10.1126/science.1165557. PMC . PMID 19213880.
- Eccles p. 77
- Pelczar (2010). Microbiology: Application Based Approach. p. 656. ISBN 978-0-07-015147-5.
- medicine, s cecil. Goldman (24th ed.). Philadelphia: Elsevier Saunders. p. 2103. ISBN 978-1-4377-2788-3.
- Michael Rajnik; Robert W Tolan (13 Sep 2013). "Rhinovirus Infection". Medscape Reference. Retrieved 19 March 2013.
- "Common Cold". National Institute of Allergy and Infectious Diseases. 27 November 2006. Retrieved 11 June 2007.
- Eccles p. 107
- Eccles, Ronald; Weber, Olaf (2009). Common cold (Online-Ausg. ed.). Basel: Birkhäuser. p. 197. ISBN 978-3-7643-9894-1.
- Eccles pp. 211, 215
- al.], edited by Arie J. Zuckerman ... [et (2007). Principles and practice of clinical virology (6th ed.). Hoboken, N.J.: Wiley. p. 496. ISBN 978-0-470-51799-4.
- Gwaltney JM Jr; Halstead SB. "Contagiousness of the common cold". Invited letter in "Questions and answers". Journal of the American Medical Association. 278 (3): 256–257. 16 July 1997. doi:10.1001/jama.1997.03550030096050. Retrieved 16 September 2011.
- Zuger, Abigail (4 March 2003). "'You'll Catch Your Death!' An Old Wives' Tale? Well..". The New York Times.
- Eccles p. 79
- "Common cold – Background information". National Institute for Health and Clinical Excellence. Retrieved 19 March 2013.
- Eccles p. 80
- Mourtzoukou EG, Falagas ME (September 2007). "Exposure to cold and respiratory tract infections". The International Journal of Tuberculosis and Lung Disease. 11 (9): 938–43. PMID 17705968.
- Eccles p. 157
- Eccles p. 78
- Eccles p. 166
- Cohen S, Doyle WJ, Alper CM, Janicki-Deverts D, Turner RB (January 2009). "Sleep habits and susceptibility to the common cold". Arch. Intern. Med. 169 (1): 62–7. doi:10.1001/archinternmed.2008.505. PMC . PMID 19139325.
- Eccles pp. 160–165
- McNiel, ME; Labbok, MH; Abrahams, SW (July 2010). "What are the risks associated with formula feeding? A re-analysis and review.". Breastfeeding Review. 18 (2): 25–32. PMID 20879657.
- Lawrence, Ruth A. Lawrence, Robert M. (2010-09-30). Breastfeeding a guide for the medical profession (7th ed.). Maryland Heights, Mo.: Mosby/Elsevier. p. 478. ISBN 9781437735901.
- Williams, [edited by] Kenrad E. Nelson, Carolyn F. Masters (2007). Infectious disease epidemiology : theory and practice (2nd ed.). Sudbury, Mass.: Jones and Bartlett Publishers. p. 724. ISBN 9780763728793.
- Eccles p. 116
- Eccles p. 122
- Eccles pp. 51–52
- Lawrence DM (May 2009). "Gene studies shed light on rhinovirus diversity". Lancet Infect Dis. 9 (5): 278. doi:10.1016/S1473-3099(09)70123-9.
- Jefferson T, Del Mar CB, Dooley L, Ferroni E, Al-Ansary LA, Bawazeer GA, van Driel ML, Nair S, Jones MA, Thorning S, Conly JM (July 2011). Jefferson T, ed. "Physical interventions to interrupt or reduce the spread of respiratory viruses". Cochrane Database of Systematic Reviews (7): CD006207. doi:10.1002/14651858.CD006207.pub4. PMID 21735402.
- Singh M, Das RR (February 2011). Singh M, ed. "Zinc for the common cold". Cochrane Database of Systematic Reviews (2): CD001364. doi:10.1002/14651858.CD001364.pub3. PMID 21328251.
- Hemilä, H; Chalker, E (31 January 2013). "Vitamin C for preventing and treating the common cold.". The Cochrane database of systematic reviews. 1: CD000980. doi:10.1002/14651858.CD000980.pub4. PMID 23440782.
- Satomura, K; Kitamura, T; Kawamura, T; Shimbo, T; Watanabe, M; Kamei, M; Takano, Y; Tamakoshi, A; Great Cold, Investigators-I (November 2005). "Prevention of upper respiratory tract infections by gargling: a randomized trial.". American journal of preventive medicine. 29 (4): 302–7. doi:10.1016/j.amepre.2005.06.013. PMID 16242593.
- "Common Cold: Treatments and Drugs". Mayo Clinic. Retrieved 9 January 2010.
- Eccles p. 261
- Kim, SY; Chang, YJ; Cho, HM; Hwang, YW; Moon, YS (4 June 2013). "Non-steroidal anti-inflammatory drugs for the common cold.". The Cochrane database of systematic reviews. 6: CD006362. doi:10.1002/14651858.CD006362.pub3. PMID 23733384.
- Eccles R (2006). "Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu". Journal of Clinical Pharmacy and Therapeutics. 31 (4): 309–319. doi:10.1111/j.1365-2710.2006.00754.x. PMID 16882099.
- Smith, SM; Schroeder, K; Fahey, T (15 August 2012). "Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory settings.". The Cochrane database of systematic reviews. 8: CD001831. doi:10.1002/14651858.CD001831.pub4. PMID 22895922.
- Smith, SM; Schroeder, K; Fahey, T (24 November 2014). "Over-the-counter (OTC) medications for acute cough in children and adults in community settings.". The Cochrane database of systematic reviews. 11: CD001831. doi:10.1002/14651858.CD001831.pub5. PMID 25420096.
- Shefrin AE, Goldman RD (November 2009). "Use of over-the-counter cough and cold medications in children" (PDF). Can Fam Physician. 55 (11): 1081–3. PMC . PMID 19910592.
- Vassilev ZP, Kabadi S, Villa R (March 2010). "Safety and efficacy of over-the-counter cough and cold medicines for use in children". Expert opinion on drug safety. 9 (2): 233–42. doi:10.1517/14740330903496410. PMID 20001764.
- Eccles p. 246
- Deckx, L; De Sutter, AI; Guo, L; Mir, NA; van Driel, ML (17 October 2016). "Nasal decongestants in monotherapy for the common cold.". The Cochrane database of systematic reviews. 10: CD009612. doi:10.1002/14651858.CD009612.pub2. PMID 27748955.
- De Sutter, AI; Saraswat, A; van Driel, ML (29 November 2015). "Antihistamines for the common cold.". The Cochrane database of systematic reviews. 11: CD009345. doi:10.1002/14651858.CD009345.pub2. PMID 26615034.
- Taverner D, Latte GJ (2007). Latte, G. Jenny, ed. "Nasal decongestants for the common cold". Cochrane Database Syst Rev (1): CD001953. doi:10.1002/14651858.CD001953.pub3. PMID 17253470.
- Deckx, Laura; De Sutter, An Im; Guo, Linda; Mir, Nabiel A.; van Driel, Mieke L. (17 October 2016). "Nasal decongestants in monotherapy for the common cold". The Cochrane Database of Systematic Reviews. 10: CD009612. doi:10.1002/14651858.CD009612.pub2. PMID 27748955.
- Albalawi ZH, Othman SS, Alfaleh K (July 2011). Albalawi ZH, ed. "Intranasal ipratropium bromide for the common cold". Cochrane Database of Systematic Reviews (7): CD008231. doi:10.1002/14651858.CD008231.pub2. PMID 21735425.
- Guppy MP, Mickan SM, Del Mar CB, Thorning S, Rack A (February 2011). Guppy MP, ed. "Advising patients to increase fluid intake for treating acute respiratory infections". Cochrane Database of Systematic Reviews (2): CD004419. doi:10.1002/14651858.CD004419.pub3. PMID 21328268.
- Singh, M; Singh, M (4 June 2013). "Heated, humidified air for the common cold.". The Cochrane database of systematic reviews. 6: CD001728. doi:10.1002/14651858.CD001728.pub5. PMID 23733382.
- Paul IM, Beiler JS, King TS, Clapp ER, Vallati J, Berlin CM (December 2010). "Vapor rub, petrolatum, and no treatment for children with nocturnal cough and cold symptoms". Pediatrics. 126 (6): 1092–9. doi:10.1542/peds.2010-1601. PMC . PMID 21059712.
- Kenealy, T; Arroll, B (4 June 2013). "Antibiotics for the common cold and acute purulent rhinitis.". The Cochrane database of systematic reviews. 6: CD000247. doi:10.1002/14651858.CD000247.pub3. PMID 23733381.
- Eccles p. 238
- Eccles p. 234
- Eccles p. 218
- Oduwole, O; Meremikwu, MM; Oyo-Ita, A; Udoh, EE (23 December 2014). "Honey for acute cough in children.". The Cochrane database of systematic reviews. 12: CD007094. doi:10.1002/14651858.CD007094.pub4. PMID 25536086.
- King, D; Mitchell, B; Williams, CP; Spurling, GK (20 April 2015). "Saline nasal irrigation for acute upper respiratory tract infections.". The Cochrane database of systematic reviews. 4: CD006821. doi:10.1002/14651858.CD006821.pub3. PMID 25892369.
- "Zinc for the common cold — Health News — NHS Choices". nhs.uk. 2012. Retrieved 24 February 2012.
In this review, there was a high level of heterogeneity between the studies that were pooled to determine the effect of zinc on the duration of cold symptoms. This may suggest that it was inappropriate to pool them. It certainly makes this particular finding less conclusive.
- Science, M.; Johnstone, J.; Roth, D. E.; Guyatt, G.; Loeb, M. (10 July 2012). "Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials". Canadian Medical Association Journal. 184 (10): E551–E561. doi:10.1503/cmaj.111990. PMC . PMID 22566526.
- "Loss of Sense of Smell with Intranasal Cold Remedies Containing Zinc". 2009.
- Heiner KA, Hart AM, Martin LG, Rubio-Wallace S (2009). "Examining the evidence for the use of vitamin C in the prophylaxis and treatment of the common cold". Journal of the American Academy of Nurse Practitioners. 21 (5): 295–300. doi:10.1111/j.1745-7599.2009.00409.x. PMID 19432914.
- Karsch-Völk M, Barrett B, Kiefer D, Bauer R, Ardjomand-Woelkart K, Linde K (2014). "Echinacea for preventing and treating the common cold". Cochrane Database Syst Rev (Systematic review). 2: CD000530. doi:10.1002/14651858.CD000530.pub3. PMC . PMID 24554461.
- Lissiman E, Bhasale AL, Cohen M (2014). Lissiman E, ed. "Garlic for the common cold". Cochrane Database Syst Rev. 11: CD006206. doi:10.1002/14651858.CD006206.pub4. PMID 25386977.
- Murdoch, David R. (3 October 2012). "Effect of Vitamin D3 Supplementation on Upper Respiratory Tract Infections in Healthy Adults: The VIDARIS Randomized Controlled Trial</subtitle>". JAMA: The Journal of the American Medical Association. 308 (13): 1333. doi:10.1001/jama.2012.12505.
- Thompson, M; Vodicka, TA; Blair, PS; Buckley, DI; Heneghan, C; Hay, AD; TARGET Programme, Team (11 Dec 2013). "Duration of symptoms of respiratory tract infections in children: systematic review.". BMJ (Clinical research ed.). 347: f7027. doi:10.1136/bmj.f7027. PMC . PMID 24335668.
- Eccles p. 76
- Eccles p. 90
- "The Cost of the Common Cold and Influenza". Imperial War Museum: Posters of Conflict. vads.
- Eccles p. 6
- "Cold". Online Etymology Dictionary. Retrieved 12 January 2008.
- Eccles p. 20
- Tyrrell DA (1987). "Interferons and their clinical value". Rev. Infect. Dis. 9 (2): 243–9. doi:10.1093/clinids/9.2.243. PMID 2438740.
- Al-Nakib W; Higgins, P.G.; Barrow, I.; Batstone, G.; Tyrrell, D.A.J. (December 1987). "Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges". J Antimicrob Chemother. 20 (6): 893–901. doi:10.1093/jac/20.6.893. PMID 3440773.
- Fendrick AM, Monto AS, Nightengale B, Sarnes M (2003). "The economic burden of non-influenza-related viral respiratory tract infection in the United States". Arch. Intern. Med. 163 (4): 487–94. doi:10.1001/archinte.163.4.487. PMID 12588210.
- Kirkpatrick GL (December 1996). "The common cold". Prim. Care. 23 (4): 657–75. doi:10.1016/S0095-4543(05)70355-9. PMID 8890137.
- Eccles p. 226
- Rider TH, Zook CE, Boettcher TL, Wick ST, Pancoast JS, Zusman BD (2011). Sambhara S, ed. "Broad-spectrum antiviral therapeutics". PLoS ONE. 6 (7): e22572. doi:10.1371/journal.pone.0022572. PMC . PMID 21818340.
- Val Willingham (12 February 2009). "Genetic map of cold virus a step toward cure, scientists say". CNN. Retrieved 28 April 2009.